Results 241 to 250 of about 3,155,630 (345)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Grain shape in rice: a Genome-wide association study of the effector genes. [PDF]

BMC Plant Biol
Wang N, Hassan MA, Li K, Zhou K, Gan Q, Xia J, Lin C, Li Z, Ni D, Song F.   +9 more
europepmc   +1 more source

A Genome- and Phenome-Wide Association Study of Serum Procalcitonin Concentrations in Individuals of European Ancestry

Wenbo Zhang, Peter J. van der Most, Siqi Wang, Zoha Kamali, Alice Giontella, Sofia Enhörning, Ron T. Gansevoort, Pim van der Harst, Stephan J. L. Bakker, Olle Melander, Frederik Keus, Gerton Lunter, Harold Snieder   +12 more
openalex   +1 more source

A genome‐wide association study for reading and language abilities in two population cohorts [PDF]

, 2013
Michelle Luciano, David M. Evans, Narelle K. Hansell, Sarah E. Medland, Grant W. Montgomery, Nicholas G. Martin, Margaret J. Wright, Timothy C. Bates   +7 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Genome-wide association study of REM sleep behavior disorder in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Sosero YL, Heilbron K, Fontanillas P, Norcliffe-Kaufmann L, Yu E, Rudakou U, Ruskey JA, Freeman K, Asayesh F, Brolin KA, Swanberg M, Morris HR, Wu L, Real R, Pihlstrøm L, Tan M, Gasser T, Brockmann K, Liu H, Hu MTM, Grosset DG, Lewis SJG, Kwok JB, Pastor P, Alvarez I, Skorvanek M, Lackova A, Ostrozovicova M, Rizig M, 23andMe Research Team, International Parkinson’s Disease Genomics Consortium, Krohn L, Gan-Or Z.   +32 more
europepmc   +1 more source

A Genome Wide Association Study Links Glutamate Receptor Pathway to Sporadic Creutzfeldt-Jakob Disease Risk

, 2015
Pascual Sánchez‐Juan, Matthew Bishop, Gábor G. Kovács, Miguel Calero, Yurii S. Aulchenko, Anna Ladogana, Alison Boyd, Victoria Lewis, Claudia Ponto, Olga Calero, Anna Poleggi, Ángel Carracedo, Sven J. van der Lee, Thomas Ströbel, Fernando Rivadeneira, Albert Hofman, Stéphane Haı̈k, Onofre Combarros, José Berciano, André G. Uitterlinden, Steven Collins, Herbert Budka, Jean‐Philippe Brandel, Jean Laplanche, Maurizio Pocchiari, Inga Zerr, Richard Knight, Robert Will, Cornelia M. van Duijn   +28 more
openalex   +2 more sources

Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network [PDF]

, 2019
Jacklyn N. Hellwege, Sarah Stallings, Eric S. Torstenson, Robert J. Carroll, Kenneth M. Borthwick, Murray H. Brilliant, David R. Crosslin, Allan Gordon, George Hripcsak, Gail P. Jarvik, James G. Linneman, Parimala Devi, Peggy Peissig, Patrick Sleiman, Håkon Håkonarson, Marylyn D. Ritchie, Shefali S. Verma, Ning Shang, Joshua C. Denny, Dan M. Roden, Digna R. Velez Edwards, Todd L. Edwards   +21 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Genome-Wide Association Study of Body Mass Index in a Commercial Landrace × Yorkshire Crossbred Pig Population. [PDF]

Vet Sci
Jin L, Bai C, Chen J, Feng C, Dong F, Zhang X, Fei J, He Y, Liu W, Chen C, Sun B, Wang D, Sun H.   +12 more
europepmc   +1 more source