Results 281 to 290 of about 3,091,688 (344)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

, 2017
Paul S. de Vries, Maria Sabater‐Lleal, Daniel I. Chasman, Stella Trompet, Tarunveer S. Ahluwalia, Alexander Teumer, Marcus E. Kleber, Ming‐Huei Chen, Jie Jin Wang, John Attia, Riccardo E. Marioni, Maristella Steri, Lu‐Chen Weng, René Pool, Vera Großmann, Jennifer A. Brody, Cristina Venturini, Toshiko Tanaka, Lynda M. Rose, Christopher Oldmeadow, Johanna Mazur, Saonli Basu, Mattias Frånberg, Qiong Yang, Symen Ligthart, Jouke‐Jan Hottenga, Ann Rumley, Antonella Mulas, Anton J. M. de Craen, Anne Grotevendt, Kent D. Taylor, Graciela E. Delgado, Annette Kifley, Lorna M. Lopez, Tina Landsvig Berentzen, Massimo Mangino, Stefania Bandinelli, Alanna C. Morrison, Anders Hamsten, Geoffrey H. Tofler, Moniek P.M. de Maat, Harmen H. M. Draisma, Gordon Lowe, Magdalena Żołędziewska, Naveed Sattar, Karl J. Lackner, Uwe Völker, Barbara McKnight, Jie Huang, Elizabeth G. Holliday, Mark McEvoy, John M. Starr, Pirro G. Hysi, Dena Hernández, Weihua Guan, Fernando Rivadeneira, Wendy L. McArdle, P. Eline Slagboom, Tanja Zeller, Bruce M. Psaty, André G. Uitterlinden, Eco J. C. de Geus, David J. Stott, Harald Binder, Albert Hofman, Oscar H. Franco, Jerome I. Rotter, Luigi Ferrucci, Tim D. Spector, Ian J. Deary, Winfried März, Andreas Greinacher, Philipp S. Wild, Francesco Cucca, Dorret I. Boomsma, Hugh Watkins, Weihong Tang, Paul M. Ridker, J. Wouter Jukema, Rodney J. Scott, Paul Mitchell, Torben Hansen, Christopher J. O’Donnell, Nicholas L. Smith, David P. Strachan, Abbas Dehghan   +85 more
openalex   +2 more sources

Genome wide association study unveils the genetic basis of Orobanche crenata resistance in pea. [PDF]

Theor Appl Genet
Wohor OZ, Rispail N, Rubiales D.
europepmc   +1 more source

Practice Recommendations for Genetic Testing of Ataxias

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan, Amy D. Mook, Michelle Rochman, Jin Yun Helen Chen, Weiyi Mu, George R. Wilmot, Liana S. Rosenthal, Wendy R. Uhlmann   +7 more
wiley   +1 more source

Genome-wide association study of pediatric bacteremia and sepsis

Lawless D, Hodel FA, Thorball CW, Xu ZM, Borghesi A, Giannoni E, Trück J, Stocker M, Posfay-Barbe KM, Heininger U, Bernhard-Stirnemann S, Niederer-Loher A, Kahlert CR, Natalucci G, Relly C, Berger C, Riedel T, Aebi C, Agyeman P, Fellay J, Schlapbach LJ.   +20 more
europepmc   +1 more source

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Genome-Wide Association Study and Candidate Gene Analysis of Seed Shattering Trait in <i>Psathyrostachys juncea</i>. [PDF]

Genes (Basel)
Lv Y, Yun L, Mu Y, Li B, Jia X, Jia M.
europepmc   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Genome-wide association study reveals E2F3 as the candidate gene for scallop growth

, 2019
Xianhui Ning, Xue Li, Jing Wang, Xiangchao Zhang, Lingling Kong, Deting Meng, Huizhen Wang, Yajuan Li, Lingling Zhang, Shi Wang, Xiaoli Hu, Zhenmin Bao   +11 more
openalex   +2 more sources

Genome-wide association study reveals genetic mechanisms underlie eye disorders and comorbidities. [PDF]

HGG Adv
Hsiung CN, Chou WC, Hsu CH, Chen L.
europepmc   +1 more source