Results 121 to 130 of about 3,210,341 (315)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function [PDF]

, 2014
Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.
Wenbo Tang (110161), Joyanna G. Hansen (591398), Heinrich, J (Joachim), Thomas Lumley (57337), London, S.J. (Stephanie), Alan James (528475), Sood, A, R Graham Barr, Matthew Kowgier (120923), Brusselle, Guy G., Loth, Daan W, Akshay Sood (71826), O'Connor, George T, Susan R. Heckbert, Liu, YM, Rivadeneira Ramirez, F. (Fernando), Hodge, E., Harris, Tamara B, Michael Allerhand, Loth Daan W., Morrison, A.C. (Alanna), Fornage, Myriam, Morris Andrew P., Ingo Ruczinski, Stephanie J. London (62450), Josée Dupuis (28859), James, Alan, Völzke Henry, Ruczinski, I., London Stephanie J., Voorman, A, Patricia A. Cassano (110298), Joachim Heinrich (60421), Guy G Brusselle, Gu, Xiangjun, Mathias, Rasika A, John M Starr, Smith, AV, Couper, DJ, Lenore J. Launer (110269), Arend Voorman, Myriam Fornage (45591), Sina A. Gharib, Smith, Lewis J, Gao, W, Wei Gao, Liu, Y, Morrison Alanna C., Kari E. North, Musk, B, Heinrich, J. (Joachim), Musk Bill, Uitterlinden, André G, Hansel, C.R.W. (Christian), Dupuis, Jos�e, John M. Starr, Heinrich, Joachim, Foy, Millennia, Lind, Lars, Cassano, P.A. (Patricia), Probst-Hensch, Nicole M, Palmer, Lyle J., O Dale Williams, Joyanna G. Hansen, Allerhand, Michael, Martin D. Tobin, Deary, Ian J, Hall, I.P. (Ian), Uitterlinden, AG, Heckbert, Susan R, David P Strachan, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Stricker, Bruno H, Starr John M., Heckbert, Susan R., Holger Schulz (13022), Tamara B. Harris, James, A. (Alan), Tobin, M.D. (Martin), Michael Allerhand (591399), Martin T. Wells, Kari E. North (68131), Aldrich, Melinda C., Couper, David J., North, Kari E, Louise V Wain, Starr, John M., Rivadeneira, F, Jerome I. Rotter, Barnes, Kathleen C, O'Connor, G.T. (George), Smith, Lewis J., Kowgier, M., Karrasch Stefan, Strachan, David P., Henry Völzke (64286), Williams O. Dale, Ingelsson, Erik, Hodge Emily, Soler Artigas, Mar�a, Bernd Meibohm (110267), Gu Xiangjun, Ingelsson Erik, Cecilia Lindgren (258113), Daan W Loth, Hofman Albert, Gl�ser, Sven, Starr, J.M. (John), Deary, I.J. (Ian), Ashish Kumar, et al., Kurt Lohman, Bonnie R. Joubert, Alanna C Morrison, Melinda C. Aldrich (110234), Meibohm, B, Ruczinski Ingo, Imboden, Medea, Gharib, Sina A, Wilk, Jemma B., Hansen, JG, Fall, Tove,, Franceschini, N. (Nora), Lahousse Lies, Kowgier Matthew, Foy Millennia, Hansel, Nadia N., Kurt Lohman (110218), O. Dale Williams (110242), Völzke, H. (Henry), Alanna C. Morrison (110248), Lenore J Launer, Gao Wei, Franceschini, N, Hansen, J., Hancock, D.B. (Dana), Probst-Hensch, NM, Morris, AP, Launer, Lenore J., R. Graham Barr, Couper David J., Gläser, S. (Sven), Li, G. (Guo), O. Connor, George T., Allerhand, M., Fernando Rivadeneira, Joubert, B.R. (Bonnie), Sina A. Gharib (63265), Eva Albrecht (174584), Heckbert Susan R., Imboden, M. (Medea), Dupuis, Josée, Gudnason, V. (Vilmundur), Gharib, S.A. (Sina), Williams, O.D. (Dale), Mathias, Rasika A., Morris, Andrew P, Tamara B. Harris (110195), Voorman Arend, Musk, Bill, Bonnie R. Joubert (110252), Probst-Hensch, Nicole M., Rotter, Jerome I, Gharib, S., Matthew Kowgier, Dana B. Hancock (110121), R. Graham Barr (109958), Lewis J. Smith, Franceschini, Nora, Hansen Joyanna G., Kathleen C. Barnes, Ruczinski, I. (Ingo), Soler Artigas, M., Loth, Daan W., Josée Dupuis, Alan James, Wei Gao (2085), Medea Imboden, Gharib Sina A., Gao, Wei, Lohman, K, Ruczinski, I, Wain, Louise V., Allerhand, M.M. (Michael), Lewis J Smith, Alan James, Rasika A. Mathias, Lohman Kurt, Wells, Martin T., Uitterlinden, A.G. (André), Andrew P Morris, Sood, A. (Akshay), George T O'Connor, McArdle, Wendy L., Barr, R. Graham, Dupuis, J, Palmer, Lyle J, Koch, B, Fall, M. (Magnus), Ian J Deary, Tobin, Martin D, Jemma B Wilk, Meibohm Bernd, Völzke, H, Davies, Gail, Artigas, Maria Soler, Lahousse, Lies, Morris, A.P. (Andrew), Melinda C Aldrich, Gudnason, V, Kumar, Ashish, Eva Albrecht, Rasika A Mathias, Gharib, SA, Wain, L.V. (Louise), Musk, A.W. (Arthur), Palmer, LJ, Franceschini Nora, Albert V Smith, Aldrich Melinda C., Uitterlinden, André G., Martin D Tobin, Guy G. Brusselle (110236), Smith Lewis J., Fall, T, Kowgier, M, Bruce M Psaty, Probst-Hensch Nicole M., Palmer, C. (Cameron), Smith, Albert V., Teumer, A, Soler Artigas, M. (Maria), Hodge, Emily, Nicole M Probst-Hensch, Morris, Andrew P., Gu, X, Louise V. Wain, Rotter Jerome I., Brusselle, G.G. (Guy), McArdle, W.L. (Wendy), Hall, IP, Meibohm, Bernd, Alanna C. Morrison, Psaty, B.M. (Bruce), Harris, TB, Kathleen C. Barnes (134420), Xiangjun Gu, Akshay Sood, Lind Lars, Lind, L, Harris, T., Daan W. Loth (110140), Curjuric, I. (Ivan), Mathias, J. (Jasmine), Starr, JM, Fall Tove, Li, Guo, Lumley, Thomas, Sven Gläser, Jemma B. Wilk, André G. Uitterlinden (2213413), Ian J. Deary, Lars Lind (88400), Barr, R., Smith, A.V. (Davey), Foy, M. (Millennia), Hofman, Albert, Deary, Ian J., Jerome I. Rotter (103729), Hansel, Nadia N, Yongmei Liu, Myriam Fornage, Cassano, Patricia A, James Alan, Teumer Alexander, Schulz Holger, André G. Uitterlinden, Xiangjun Gu (73651), Davies Gail, Tang, W, Brusselle, GG, Soler Artigas María, Bruno H. Stricker, Tang, Wenbo, Voelzke, Henry, Stricker, Bruno H., Ingelsson, E, Strachan, D.P. (David), Smith, A., Stephen B Kritchevsky, Dana B Hancock, Vilmundur Gudnason (8873), Strachan, DP, Lumley Thomas, Patricia A Cassano, Susan R. Heckbert (110293), Martin D. Tobin (110311), Andrew P. Morris, Imboden Medea, North, KE, Dupuis, J. (Josée), David J Couper, Bruno H. Stricker (336134), Rotter, JI, Davies, G. (Gail), Tove Fall, John M. Starr (107707), Lind, Lars,, Psaty, Bruce M., Wells, MT, Dupuis Josée, Lohman, Kurt, Hodge, E, Lars Lind, Gail Davies, Hancock Dana B., Gudnason, V., Hansen, Joyanna G, Henry Völzke, Bruce M. Psaty, Morrison, Alanna C, Tobin, MD, Wain, LV, Mathias, RA, Stricker, Bruno, Barr, RG, Wells, M.T. (Martin), Lies Lahousse, Alexander Teumer (112757), Lies Lahousse (548910), Strachan David P., Bill Musk, Palmer Lyle J., Schulz, H. (Holger), Strachan, David P, Schulz, H, Brusselle, Guy, Mathias, R., Stephen B. Kritchevsky, George T. O′Connor (591401), O′Connor, George T., Ian J. Deary (107724), Wendy L. McArdle (110155), Bill Musk (591400), Bernd Meibohm, Karrasch, S, Tove Fall (201258), Fornage Myriam, Hansen, J.G. (Joyanna), Teumer, A. (Alexander), Barr, R Graham, Voorman, J.M. (Jeanine), Ruczinski, Ingo, Hofman, Bert, Arend Voorman (221264), Lindgren, Cecilia, Stephen B. Kritchevsky (110259), Liu, Y. (YongMei), Bonnie R Joubert, Ingo Ruczinski (15765), David J. Couper (110257), Hansel, NN, Davies, G, V�lzke, Henry, Erik Ingelsson, Rasika A. Mathias (134405), Rotter, J.I. (Jerome), Psaty, Bruce M, Sven Gläser (110276), Koch Beate, Albrecht Eva, Aldrich, MC, Hancock, DB, Albrecht, E. (Eva), Heckbert, SR, Mathias Rasika A., North, Kari E., Wilk Jemma B., Probst-Hensch, N.M. (Nicole M.), Lumley, T, Aldrich, M., Kowgier, Matthew, Stefan Karrasch (412837), Ashish Kumar (152984), Rivadeneira Fernando, Wenbo Tang, Beate Koch (110151), Hansel, N., Fall, Tove, Albert V. Smith, Koch, B. (Beate), Tobin Martin D., Williams, O. Dale, Uitterlinden, André, Hancock, Dana B., Heckbert, S.R. (Susan), Ian P. Hall (110307), Karrasch, S. (Stefan), David P. Strachan, Kumar, A, Kritchevsky, SB, Nora Franceschini, Jemma B. Wilk (110164), Curjuric, Ivan, Emily Hodge (460149), Brusselle Guy G., Dana B. Hancock, North, K.E. (Kari), Vilmundur Gudnason, Andrew P. Morris (145709), Emily Hodge, Artigas, MS, Rivadeneira, Fernando, Aldrich, M.C. (Melinda), Bruno H Stricker, Loth, D.W. (Daan), Guy G. Brusselle, Stricker, B.H.Ch. (Bruno), Albert V. Smith (103644), Morrison, Alanna C., Stephanie J. London, Lewis J. Smith (156533), Stefan Karrasch, Loth, DW, Wilk, J.B. (Jemma), London, SJ, Curjuric Ivan, Launer Lenore J., Deary, IJ, Karrasch, Stefan, Lindgren Cecilia, Kathleen C Barnes, Völzke, Henry, Lyle J Palmer, Lindgren, C, Barnes, KC, Lenore J. Launer, Li, G, O'Connor, GT, Schulz, Holger, Lindgren, C.M. (Cecilia), Heinrich, J, Tang, W. (Wenbo), Barnes, K., Joubert, B., Bruce M. Psaty (103721), Loth, D., Uitterlinden, Andr� G., Nadia N Hansel, Gu, XJ, Millennia Foy (211777), Ivan Curjuric (110179), Nadia N. Hansel (359186), Hansen, Joyanna G., Susan R Heckbert, Sina A Gharib, Gläser, Sven, Cecilia Lindgren, McArdle Wendy L., Medea Imboden (110145), Thomas Lumley, Teumer, Alexander, Martin T. Wells (122541), Harris, Tamara B., London, Stephanie J, Albrecht, E., Joubert, BR, O?Connor, George T., Allerhand, M, Jerome I Rotter, David J. Couper, Wendy L. McArdle, Launer, LJ (Lenore), Gudnason, Vilmundur, Tang Wenbo, Martin T Wells, Smith, L.J. (Lewis), Lohman, K. (Kurt), Uitterlinden, André; id_orcid, Smith Albert V., Loth, Daan, Hall, Ian P, Barr R. Graham, Liu, Yongmei, Guo Li (174860), Nicole M. Probst-Hensch (110284), Wilk, JB, Kritchevsky Stephen B., Chen, Lin, Gail Davies (107670), Ivan Curjuric, Gudnason Vilmundur, Curjuric, I, Allerhand Michael, Sood Akshay, Lahousse, L, Lahousse, L. (Lies), Nicole M. Probst-Hensch, Soler Artigas, María, Williams, O Dale, Launer, L., Kumar Ashish, Guo Li, Gläser, S, Heinrich Joachim, Morrison, AC, Hofman, A. (Albert), Fornage, M. (Myriam), Albert Hofman, Hall Ian P., London, Stephanie J., Fornage, M, Harris Tamara B., Uitterlinden André G., Stricker Bruno H., Gharib, Sina A., André G Uitterlinden, North Kari E., Daan W. Loth, O Connor, George T, María Soler Artigas (110124), Hansel Nadia N., Gläser Sven, O'Connor, George T., Joyanna G Hansen, Wells Martin T., Smith, LJ, Lyle J. Palmer (95287), Gao, W. (Wei), McArdle, Wendy L, Foy, M, Ingelsson, E. (Erik), Deary Ian J., Kritchevsky, Stephen B, Lyle J. Palmer, Glaeser, Sven, Aldrich, Melinda C, Brusselle, Guy G, Liu Yongmei, Joubert, Bonnie R., Imboden, M, Barnes, Kathleen C., Ian P Hall, Alexander Teumer, Sood, Akshay, McArdle, WL, Couper, D.J. (David), Soler Artigas, M, Wain Louise V., Kari E North, Couper, David J, Starr, John M, Psaty, BM, Wenbo Tang, Albrecht, E, Louise V. Wain (110260), Hancock, Dana B, Li Guo, Koch, Beate, David P. Strachan (110302), Cassano, PA, Barnes Kathleen C., Joubert, Bonnie R, Stephanie J London, Ian P. Hall, Gu, X. (Xiangjun), Tang, W., Kritchevsky, Stephen B., Lind, L. (Lars), O. Dale Williams, Hofman, A, Lumley, T. (Thomas), Melinda C. Aldrich, Launer, L.J. (Lenore), James, A, Cassano Patricia A., Holger Schulz, Albert Hofman (107303), Voorman, Arend, O′Connor George T., Stricker, BH, Beate Koch, Launer, LJ, George T. O′Connor, Psaty Bruce M., Cassano, Patricia A., Wells, Martin T, Joachim Heinrich, Tang, WB, Ingelsson, Erik,, Barnes, K.C. (Kathleen), Albrecht, Eva, Hodge, E. (Emily), Hall, Ian P., Nora Franceschini (91434), Tobin, Martin D., Barr, R.G. (Graham), Wain, Louise V, Rotter, Jerome I., Kritchevsky, S.B. (Stephen), Joubert Bonnie R., Nadia N. Hansel, Wendy L McArdle, Millennia Foy, Williams, OD, Erik Ingelsson (232651), Kowgier, M. (Matthew), Patricia A. Cassano, Wilk, Jemma B, Meibohm, B. (Bernd), María Soler Artigas, Yongmei Liu (104713), Fernando Rivadeneira (61551), Kumar, A. (Ashish)   +616 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Evaluation of association of HNF1B variants with diverse cancers : collaborative analysis of data from 19 genome-wide association studies [PDF]

, 2010
Background Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk.
Tomlinson, IP, Mann, GJ, Hwang, Shih-Jen, Hopper, John L., Hwang, SJ, Amos, CI, Barkardottir, Rosa B., McCarthy, Mark I, Carvajal-Carmona Luis, Albanes, D, Xu, J, Armstrong, Bruce K., Kenneth Muir, Stefansson Kari, Jacobs, EJ, Amos Christopher I., Zanke, B, Barkardottir, Rosa B, Jenab, M, Michaud, DS, Xu Jianfeng, Mendelsohn, JB, Muir, K, Hamdy, Freddie C., Stolzenberg-Solomon, RZ, Aitken, JF, Mathieu Lemire, Aitken, Joanne F., John P. A. Ioannidis, null null, Hunter, David, Hallmans, G, Donovan, Jenny L, Murabito Joanne M., Risch, HA, Hamdy, FC, Rafnar Thorunn, Giles, Graham G., Donovan, JL, Tomlinson, Ian P. M., Hunter David J., Margaret R Spitz, Macgregor, Stuart, Tomlinson Ian P. M., Spitz, Margaret R., Hopper, JL, David E. Neal, Duell, EJ, Stefansson, K, Simon N Stacey, Gudbjartsson, Daniel F, Julius Gudmundsson, David J Hunter, Armstrong, BK, Neal David E., Easton Douglas F., Amundadottir, L, Kari Stefansson, Stephen J Chanock, Hayward Nicholas K., Zeggini, E, Neal, David E, Isaacs, William B, Easton, DF, Chanock, Stephen J, Patel, AV, Douglas F. Easton, Brown Kevin M., Petersen, GM, Thorlacius, Steinunn, Isaacs, William B., William B Isaacs, Gallinger, S, Klein, AP, Gaborieau Valerie, Donovan, Jenny, Kraft, P, Kevin M Brown, Giovannucci, EL, Holly, EA, Lemire, Mathieu, Rosa B. Barkardottir, Sulem, P, Barkardottir, RB, Neal, David E., Zeggini, Eleftheria, Valerie Gaborieau, Chanock, Stephen J., Kevin M. Brown, Zeggini Eleftheria, Barkardottir, Rosa, HASH(0x55a67fc6f008), Riboli, E, Hayward, NK, Shu, XO, Howard, B, David E Neal, Stacey, Simon N., Gronberg, H, PanScan, C, Parikh, H, Gudmundsson Julius, Hassan, M, Ian P. M. Tomlinson, Tomlinson, IPM, Ioannidis, JPA, Gudmundsson, Julius, Carvajal-Carmona, Luis, McCarthy, MI, Kefford, Richard F., Clipp, S, McCarthy Mark I., Donovan Jenny L., Brent Zanke, Muir, Kenneth, Neal, DE, Ioannidis, John P., Li, D, Amundadottir Laufey, Canzian, F, Eeles, RA, Rodriguez, L, Gudmundsson, J, Mark I. McCarthy, Xu, Jianfeng, Elliott, Katherine S, Hutchinson, A, Krogh, V, Mann, Graham J., Thomas, G, Ioannidis, John PA, Eeles Rosalind A., Brown, Kevin M., Stacey, SN, Ioannidis, John, Kefford, RF, Sulem, Patrick, Katherine S Elliott, Gudbjartsson Daniel F., Murabito, JM, Stacey Simon N., McCarthy, Mark I., Gudbjartsson, DF, Hamdy Freddie C., Jenny L. Donovan, Eleftheria Zeggini, Hunter, David J., Luis Carvajal-Carmona, Chanock, Stephen, Hayward, Nicholas K., Michael Gaziano, J, Hunter, David J, Shih-Jen Hwang, Jianfeng Xu, The PanScan Consortium, Buring, JE, Amos, Christopher I, Henrik Grönberg, PanScan Consortium, Giles, GG, Rafnar, Thorunn, Easton, Douglas F, Nicholas K. Hayward, Brown, KM, Chanock Stephen J., Jenny L Donovan, Rosalind A Eeles, Arslan, AA, Seminara, D, Goggins, M, Stefansson, Kari, Murabito, Joanne M., Hunter, DJ, McCarthy, Mark, Tomlinson, Ian PM, Donovan, Jenny L., Rajkovic, A, Zanke Brent, Hamdy, Freddie C, Nicholas K Hayward, Thorlacius Steinunn, Hayward, Nicholas K, Joanne M. Murabito, Lynch, SM, Isaacs William B., Daniel F. Gudbjartsson, Elliott, Katherine S., Ioannidis, John P. A., Fuchs, CS, de Andrade, M, Hankinson, SE, Grönberg Henrik, Lemire Mathieu, Christopher I. Amos, Gross, M, Mandelson, MT, Spitz, Margaret R, Ioannidis, John P.A., Helzlsouer, K, Laufey Amundadottir, Bracci, PM, Tomlinson, Ian, Kooperberg, C, Kurtz, RC, Grönberg, H, John P A Ioannidis, Sulem Patrick, Eeles, Rosalind A, McWilliams, RR, Gaborieau, V, Elliott Katherine S., Ioannidis, JP, Christopher I Amos, Tjønneland, A, Stuart Macgregor, Rosalind A. Eeles, Berg, CD, Rosa B Barkardottir, Joanne M Murabito, Isaacs, WB, Elliott, KS, Bamlet, WR, Freddie C. Hamdy, Macgregor, S, Freddie C Hamdy, Grönberg, Henrik, Carvajal-Carmona, L, Gaborieau, Valerie, Easton, Douglas F., Lemire, M, Rafnar, T, Simon N. Stacey, Olson, SH, Amundadottir, Laufey, Chanock, SJ, Cotterchio, M, Muir Kenneth, Stephen J. Chanock, Australian Melanoma Family Study Investigators, Ioannidis John P. A., Margaret R. Spitz, Thorlacius, S, Stacey, Simon N, Tomlinson, Ian P M, Spitz Margaret R., Ioannidis, John P A, Brennan Paul, Steinunn Thorlacius, Mark I McCarthy, Lacroix, A, Paul Brennan, David J. Hunter, Patrick Sulem, William B. Isaacs, Brennan, P, Hwang Shih-Jen, Brown, Kevin M, Douglas F Easton, Daniel F Gudbjartsson, Zheng, W, Katherine S. Elliott, Gudbjartsson, Daniel Fannar, Thorunn Rafnar, Bas Bueno-De-Mesquita, H, Hamdy, Freddie, Boutron-Ruault, MC, Gudbjartsson, Daniel F., Tomlinson, Ian P.M., Zanke, Brent, Macgregor Stuart, Barkardottir Rosa B., Amos, Christopher I., Murabito, Joanne M, Jacobs, KB, Australian, MFSI, Brennan, Paul, Peeters, PHM, Spitz, MR, Kaaks, R, Eeles, Rosalind A., Ian P M Tomlinson   +280 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment [PDF]

, 2014
Specific language impairment (SLI) is a neurodevelopmental disorder that affects linguistic abilities when development is otherwise normal. We report the results of a genome-wide association study of SLI which included parent-of-origin effects and child ...
Newbury, Dianne F, Bolton, Patrick F, A. O'Hare, Paracchini, S., Fisher, S E, Hennessy, E. R., Monaco, Anthony P, Simpson, N., Fisher, S. E., S. E. Fisher, Simpson, N H, Ring, S M, O'Hare, A., N. H. Simpson, Newbury, D., S. Paracchini, Bolton, P F, Ring, SM, Nudel, R, Smith, G D, Smith, G., Monaco, AP, P. F. Bolton, Simpson, N. H., Smith, George Davey, O'Hare, Anne, O'Hare, A, ?, ?, Hennessy, ER, E. R. Hennessy, G. Baird, Conti-Ramsden, G., Nudel, Ron, Francks, Clyde, O’Hare, A., S. M. Ring, Monaco, A., Paracchini, Silvia, Simpson, Nuala H, Nudel, R., Bolton, PF, Baird, Gillian, D. F. Newbury, Newbury, D F, Bolton, P. F., Hennessy, E., C. Francks, Newbury, D. F., Baird, G., The SLli consortium, Smith, G. Davey, G. Conti‐Ramsden, SLI Consortium, Fisher, Simon E, Cohen, Wendy, Ring, Susan M, Davey Smith, G, R. Nudel, Baird, G, Fisher, S., Bolton, P., The SLI Consortium, Fisher, SE, Conti-Ramsden, G, Simpson, NH, Conti-Ramsden, Gina, Francks, C., Monaco, A. P., Hennessy, Elizabeth R, A. P. Monaco, Paracchini, S, Francks, C, Monaco, A P, The SLI Consortium (includes Wendy Cohen), Ring, S. M., Newbury, DF, Ring, S., G. Davey Smith, Hennessy, E R   +78 more
core   +1 more source

The Genome-Wide DNA Methylation Profile of Peripheral Blood Is Not Systematically Changed by Short-Time Storage at Room Temperature

Epigenomes, 2017
Background: Epigenetic epidemiology has proven an important research discipline in the delineation of diseases of complex etiology. The approach, in such studies, is often to use bio-banked clinical material, however, many such samples were collected for
Nicklas Heine Staunstrup, Anna Starnawska, Mette Nyegaard, Anders Lade Nielsen, Anders Dupont Børglum, Ole Mors   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
Palmer, C. N. A.; id_orcid, H.M. Colhoun, C.N.A. Palmer, Colhoun, H. M., L.A. Donnelly, Liu, Y., Zhou, K., Palmer, C. N A, van Zuydam, N. R., Smith, B. H.; id_orcid, H.A. Deshmukh, N.R. van Zuydam, K. Zhou, A.D. Morris, Donnelly, L. A., Deshmukh, H. A., Morris, A. D., Meng, W., Smith, B. H., Y. Liu, B.H. Smith, W. Meng   +21 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source