Results 261 to 270 of about 827,205 (291)
Some of the next articles are maybe not open access.
A pathway analysis method for genome‐wide association studies
Statistics in Medicine, 2012For genome‐wide association studies, we propose a new method for identifying significant biological pathways. In this approach, we aggregate data across single‐nucleotide polymorphisms to obtain summary measures at the gene level. We then use a hierarchical Bayesian model, which takes the gene‐level summary measures as data, in order to evaluate the ...
Babak, Shahbaba +2 more
openaire +2 more sources
A univariate perspective of multivariate genome‐wide association analysis
Genetic Epidemiology, 2018ABSTRACTMultiple correlated phenotypes are frequently collected in genome‐wide association studies (GWASs), and a systematic, simultaneous analysis of multiple phenotypes can integrate the signals from single phenotypes, therefore increasing the power of detecting genetic signals. However, fundamental questions remain open, including the conditions and
Xiaobo Guo +5 more
openaire +2 more sources
Genome-wide association analysis of lead accumulation in maize
Molecular Genetics and Genomics, 2017Large phenotypic variations in the lead (Pb) concentration were observed in grains and leaves of maize plants. A further understanding of inheritance of Pb accumulation may facilitate improvement of low-Pb-accumulating cultivars in maize. A genome-wide association study was conducted in a population of 269 maize accessions with 43,737 single-nucleotide
Xiongwei Zhao +13 more
openaire +2 more sources
Cloud Computing for Genome-Wide Association Analysis
2012With the increasing availability and affordability of genome-wide genotyping and sequencing technologies, biomedical researchers are faced with increasing computational challenges in managing and analyzing large quantities of genetic data. Previously, this data intensive research required computing and personnel resources accessible only to large ...
James W. Baurley +2 more
openaire +1 more source
Advancing the use of genome-wide association studies for drug repurposing
Nature Reviews Genetics, 2021Murray Cairns
exaly
Genome-Wide Association Analysis Of Sepsis
B110. GENOMICS, METABOLOMICS, AND EPIGENETICS IN LUNG DISEASE: LATE BREAKING ABSTRACTS, 2012Zhaoxi Wang +6 more
openaire +1 more source
The power of genetic diversity in genome-wide association studies of lipids
Nature, 2021Sarah E Graham +2 more
exaly
Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine
Nature Reviews Drug Discovery, 2016Kathleen M Giacomini +2 more
exaly