Results 231 to 240 of about 450,356 (259)

Genome-Wide Association Studies of Cancer

Future Oncology, 2007
Genome-wide association studies provide a new and powerful approach to investigate the effect of inherited genetic variation on the risk of human disease. These studies rely on high throughput DNA microarray technology to genotype hundreds of thousands of genetic variants across the human genome.
Eric, Jorgenson, John S, Witte
openaire   +2 more sources

Genome-wide association studies in atherothrombosis

European Journal of Internal Medicine, 2010
Atherothrombotic diseases are complex diseases, arising from the interaction between several genetic and environmental factors. Until recently, the genetic basis of complex diseases in general, and of atherothrombosis in particular, were poorly characterized.
openaire   +2 more sources

Genome-Wide Association Study in Humans

2009
Genome-wide association studies have opened a new era in the study of the genetic basis of common, multifactorial diseases and traits. Before the introduction of this approach only a handful of common genetic variants showed consistent association for any phenotype.
J Gustav, Smith, Christopher, Newton-Cheh   +1 more
openaire   +2 more sources

Analysis of Genome-Wide Association Studies

Genome-wide association studies (GWAS) aim to identify genetic variants across the whole genome associated with the phenotype of interest. This technique has been largely used in the bone field to elucidate the genetic architecture of complex traits, like bone mineral density or fracture risk, and to date, more than 600 loci have been identified.
Piyush, Gampawar, Edith, Hofer, Nerea, Alonso   +2 more
openaire   +2 more sources

The road to genome-wide association studies

Nature Reviews Genetics, 2008
The recent crop of results from genome-wide association studies might seem like a sudden development. However, this blooming follows a long germination period during which the necessary concepts, resources and techniques were developed and assembled.
openaire   +2 more sources

Family-Based Genome-Wide Association Studies

Pharmacogenomics, 2009
In the last 2 years, the effort to identify genes affecting common diseases and complex traits has been accelerated through the use of genome-wide association studies (GWAS). The availability of existing large collections of linkage data paved the way for the use of family-based GWAS.
Benyamin, Beben, Visscher, Peter M., McRae, Allan F.   +2 more
openaire   +5 more sources

Study Designs for Genome‐Wide Association Studies

2008
Advances in high-throughput genotyping and a flood of data on human genetic variation from the Human Genome and HapMap projects have made genome-wide association studies technically feasible. However, researchers designing such studies face a number of challenges, including how to avoid subtle systematic biases and how to achieve sufficient statistical
Peter, Kraft, David G, Cox
openaire   +2 more sources

Genome-Wide Association Studies

JAMA, 2019
Xiuqing, Guo, Jerome I, Rotter
openaire   +3 more sources

Quality Control for Genome-Wide Association Studies

2013
This chapter overviews the quality control (QC) issues for SNP-based genotyping methods used in genome-wide association studies. The main metrics for evaluating the quality of the genotypes are discussed followed by a worked out example of QC pipeline starting with raw data and finishing with a fully filtered dataset ready for downstream analysis.
Gondro, Cedric, Lee, Seung Hwan, Lee, Hak Kyo, Porto-Neto, Laercio R.   +3 more
openaire   +5 more sources

Genome-Wide Association Studies

Nature Reviews Methods Primers, 2021
Jantina de Vries, Danielle Posthuma, Yukinori Okada   +2 more
exaly   +2 more sources