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Genome-Wide Association Studies of Cancer
Future Oncology, 2007Genome-wide association studies provide a new and powerful approach to investigate the effect of inherited genetic variation on the risk of human disease. These studies rely on high throughput DNA microarray technology to genotype hundreds of thousands of genetic variants across the human genome.
Eric, Jorgenson, John S, Witte
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[Genome-wide association studies].
Ugeskrift for laeger, 2008Within the last year, genome-wide association (GWA) studies have identified a large number of robust associations between genetic variants and common diseases. Two key premises underlie this burst of discovery. First, the HapMap project has provided a catalogue of human genetic variation.
Bjarke, Feenstra +2 more
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[Genome-wide association studies].
Deutsche medizinische Wochenschrift (1946), 2011Genome-wide association studies (GWAS) are aimed to identify genetic markers of complex human diseases and individual traits. In this context more than 150 gene loci have been found to be associated with about 60 different diseases and personal characteristics.
D, Grimm, H E, Blum, R, Thimme
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R for Genome-Wide Association Studies
2013In recent years R has become de facto statistical programming language of choice for statisticians and it is also arguably the most widely used generic environment for analysis of high-throughput genomic data. In this chapter we discuss some approaches to improve performance of R when working with large SNP datasets.
Gondro, Cedric +2 more
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Principal components analysis corrects for stratification in genome-wide association studies
Nature Genetics, 2006A. Price +5 more
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Genome-Wide Association Study in Humans
2009Genome-wide association studies have opened a new era in the study of the genetic basis of common, multifactorial diseases and traits. Before the introduction of this approach only a handful of common genetic variants showed consistent association for any phenotype.
J Gustav, Smith +1 more
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Genome-wide association studies in atherothrombosis
European Journal of Internal Medicine, 2010Atherothrombotic diseases are complex diseases, arising from the interaction between several genetic and environmental factors. Until recently, the genetic basis of complex diseases in general, and of atherothrombosis in particular, were poorly characterized.
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A new multipoint method for genome-wide association studies by imputation of genotypes
Nature Genetics, 2007J. Marchini +4 more
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Genome-wide association studies for common diseases and complex traits
Nature reviews genetics, 2005J. Hirschhorn, M. Daly
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Genome-wide association studies for complex traits: consensus, uncertainty and challenges
Nature reviews genetics, 2008M. McCarthy +6 more
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