Results 171 to 180 of about 1,111,517 (383)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Nature, 2007 P. Burton, D. Clayton, L. Cardon, N. Craddock, P. Deloukas, A. Duncanson, D. Kwiatkowski, M. McCarthy, W. Ouwehand, N. Samani, J. Todd, P. Donnelly, J. Barrett, D. Davison, D. Easton, David Evans, H. Leung, J. Marchini, A. Morris, C. Spencer, M. Tobin, A. Attwood, J. Boorman, B. Cant, Ursula Everson, Judith M. Hussey, J. Jolley, A. S. Knight, K. Koch, Elizabeth Meech, S. Nutland, C. Prowse, H. Stevens, N. Taylor, G. Walters, N. Walker, N. Watkins, T. Winzer, Richard W Jones, W. McArdle, S. Ring, D. Strachan, M. Pembrey, G. Breen, D. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. Green, D. Grozeva, M. Hamshere, P. Holmans, I. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. O’Donovan, M. Owen, D. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. Young, I. Ferrier, S. Ball, A. Balmforth, J. Barrett, D. Bishop, M. Iles, A. Maqbool, N. Yuldasheva, A. Hall, P. Braund, R. Dixon, M. Mangino, Suzanne E Stevens, J. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. Lees, E. Nimmo, J. Satsangi, S. Fisher, A. Forbes, C. Lewis, Clive M. Onnie, N. Prescott, J. Sanderson, C. Mathew, J. Barbour, M. Mohiuddin, C. Todhunter, J. Mansfield, T. Ahmad, Fraser Cummings, D. Jewell, J. Webster, Morris J. Brown, G. Lathrop, J. Connell, A. Dominiczak, C. Marcano, B. Burke, R. Dobson, J. Gungadoo, Kate L. Lee, P. Munroe, S. Newhouse, Abiodun K Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. Bruce, Hannah Donovan, S. Eyre, Paul D. Gilbert, S. Hider, A. Hinks, S. John, C. Potter, A. Silman, D. Symmons, W. Thomson, Jane Worthington, D. Dunger, B. Widmer, T. Frayling, R. Freathy, H. Lango, J. Perry, B. Shields, M. Weedon, A. Hattersley, G. Hitman, M. Walker, K. Elliott, C. Groves, C. Lindgren, N. W. Rayner, N. Timpson, E. Zeggini, M. Newport, G. Sirugo, Emily J. Lyons, F. Vannberg, A. Hill, L. Bradbury, C. Farrar, J. J. Pointon, Paul Wordsworth, M. Brown, J. Franklyn, J. Heward, M. Simmonds, S. Gough, S. Seal, M. Stratton, N. Rahman, M. Ban, A. Goris, S. Sawcer, Alastair Compston, D. Conway, M. Jallow, K. Rockett, S. Bumpstead, Amy Chaney, K. Downes, Mohammed J. R. Ghori, R. Gwilliam, S. Hunt, M. Inouye, A. Keniry, E. King, R. McGinnis, Simon C. Potter, R. Ravindrarajah, P. Whittaker, Claire Widden, D. Withers, Niall J. Cardin, T. Ferreira, Joanne Pereira-Gale, Ingileif B. Hallgrímsdóttir, Bryan N. Howie, Z. Su, Y. Teo, Damjan Vukcevic, D. Bentley, A. Compston +195 moresemanticscholar +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceA multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci [PDF]
, 2018 Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark Kvale, Yambazi Banda, Nicholas Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair, Eric Jorgenson +15 moreopenalex +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceA genome-wide association study reveals specific transferases as candidate loci for bovine milk oligosaccharides synthesis. [PDF]
, 2019 BackgroundHuman milk oligosaccharides (OS) play a key role in brain and gut microbiota development of the neonate, but the underlying biosynthetic steps of OS in the mammary gland are still largely unknown.Barile, Daniela, Buitenhuis, Bart, Larsen, Lotte B, Poulsen, Nina A, Robinson, Randall C +4 morecore +1 more sourceGenome-wide association study identifies novel breast cancer susceptibility loci
Nature, 2007 Don M. Conroy, M. Shah, Hannah Munday, C. Jordan, B. Perkins, Judy West, Karen Redman, K. Driver, M. Aghmesheh, D. Amor, Lesley Andrews, Y. Antill, Jane Armes, Shane Armitage, Leanne Arnold, Rosemary L. Balleine, Glenn Begley, J. Beilby, Ian Bennett, Barbara Bennett, Geoffrey Berry, Anneke Blackburn, Meagan Brennan, Melissa Brown, Michael Buckley, J. Burke, P. Butow, Keith Byron, David F. Callen, Ian Campbell, G. Chenevix-Trench, Christine L. Clarke, Alison Colley, Dick Cotton, Jisheng Cui, Bronwyn Culling, Margaret Cummings, Sarah-Jane Dawson, Joanne Dixon, Alexander Dobrovic, Tracy Dudding, Ted Edkins, M. Eisenbruch, G. Farshid, Susan Fawcett, Michael Field, F. Firgaira, Jean Fleming, John F Forbes, M. Friedlander, Clara Gaff, Mac Gardner, M. Gattas, Peter George, G. Giles, G. Gill, Jack Goldblatt, Sian Greening, S. Grist, E. Haan, Marion Harris, Stewart Hart, N. Hayward, J. Hopper, Evelyn Humphrey, M. Jenkins, Alison Jones, R. Kefford, Judy Kirk, James Kollias, Sergey Kovalenko, Sunil R. Lakhani, Jennifer Leary, Jacqueline Lim, Geoff Lindeman, Lara Lipton, Lizz Lobb, Mariette Maclurcan, Graham J. Mann, Deb Marsh, M. Mccredie, Michael McKay, Sue-Anne McLachlan, B. Meiser, R. Milne, Gillian Mitchell, Beth Newman, Imelda O’Loughlin, Lester Peters, K. Phillips, Melanie Price, Jeanne Reeve, Tony Reeve, Gina Rinehart, Bridget Robinson, Elizabeth Salisbury, J. Sambrook, Christobel Saunders, C. Scott, Elizabeth Scott, Rodney J. Scott, Andrew N Shelling, M. Southey, A. Spurdle, Graeme Suthers, Donna Taylor, Christopher Tennant, Heather Thorne, S. Townshend, Kathy Tucker, Janet Tyler, D. Venter, J. Visvader, I. Walpole, Robin Ward, P. Waring, Bev Warner, Graham Warren, Elizabeth Watson, Rachael Williams, Judy Wilson, Ingrid Winship, Adele Green, D. Gertig, P. Webb +124 moresemanticscholar +1 more source
