Results 171 to 180 of about 674,070 (352)

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Nature Genetics, 2020
K. Ishigaki, M. Akiyama, M. Kanai, A. Takahashi, Eiryo Kawakami, Hiroki Sugishita, S. Sakaue, N. Matoba, Siew-Kee Low, Y. Okada, C. Terao, Tiffany Amariuta, S. Gazal, Y. Kochi, M. Horikoshi, Ken Suzuki, K. Ito, S. Koyama, K. Ozaki, S. Niida, Yasushi Sakata, Yasuhiko Sakata, T. Kohno, K. Shiraishi, Y. Momozawa, M. Hirata, K. Matsuda, M. Ikeda, N. Iwata, S. Ikegawa, I. Kou, Toshihiro Tanaka, H. Nakagawa, A. Suzuki, T. Hirota, M. Tamari, K. Chayama, D. Miki, Masaki Mori, S. Nagayama, Y. Daigo, Y. Miki, T. Katagiri, O. Ogawa, W. Obara, Hidemi Ito, Teruhiko Yoshida, I. Imoto, Takashi Takahashi, C. Tanikawa, Takao Suzuki, N. Sinozaki, S. Minami, H. Yamaguchi, S. Asai, Yasuo Takahashi, K. Yamaji, Kazuhisa Takahashi, T. Fujioka, R. Takata, H. Yanai, A. Masumoto, Y. Koretsune, H. Kutsumi, M. Higashiyama, S. Murayama, N. Minegishi, Kichiya Suzuki, K. Tanno, A. Shimizu, T. Yamaji, M. Iwasaki, N. Sawada, H. Uemura, Keitaro Tanaka, M. Naito, Makoto Sasaki, K. Wakai, S. Tsugane, Masayuki Yamamoto, Kazuhiko Yamamoto, Y. Murakami, Yusuke Nakamura, S. Raychaudhuri, J. Inazawa, T. Yamauchi, T. Kadowaki, M. Kubo, Y. Kamatani   +88 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Fast pairwise IBD association testing in genome-wide association studies [PDF]

, 2013
Buhm Han, Eun Yong Kang, Soumya Raychaudhuri, Paul I. W. de Bakker, Eleazar Eskin   +4 more
openalex   +1 more source

Supplementary Materials from A Genome-Wide Association Study Identifies a Locus on Chromosome 14q21 as a Predictor of Leukocyte Telomere Length and as a Marker of Susceptibility for Bladder Cancer

, 2023
Jian Gu, Meng Chen, Sanjay Shete, Christopher I. Amos, Ashish M. Kamat, Yuanqing Ye, Jie Lin, Colin P. Dinney, Xifeng Wu   +8 more
openalex   +1 more source

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

Nature Genetics, 2007
D. Hunter, P. Kraft, K. Jacobs, D. Cox, M. Yeager, S. Hankinson, S. Wacholder, Zhaoming Wang, R. Welch, A. Hutchinson, Junwen Wang, Kai Yu, N. Chatterjee, N. Orr, W. Willett, Graham A Colditz, R. Ziegler, C. Berg, S. Buys, C. McCarty, H. Feigelson, E. Calle, M. Thun, R. Hayes, M. Tucker, D. Gerhard, J. Fraumeni, R. Hoover, G. Thomas, S. Chanock   +29 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genome-wide association study reveals E2F3 as the candidate gene for scallop growth

, 2019
Xianhui Ning, Xue Li, Jing Wang, Xiangchao Zhang, Lingling Kong, Deting Meng, Huizhen Wang, Yajuan Li, Lingling Zhang, Shi Wang, Xiaoli Hu, Zhenmin Bao   +11 more
openalex   +2 more sources

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Nature Genetics, 2018
R. Malik, G. Chauhan, M. Traylor, M. Sargurupremraj, Y. Okada, A. Mishra, L. Rutten-Jacobs, A. Giese, S. W. van der Laan, S. Gretarsdottir, C. Anderson, M. Chong, H. Adams, T. Ago, P. Almgren, P. Amouyel, H. Ay, Traci M. Bartz, O. Benavente, S. Bevan, G. Boncoraglio, Robert D. Brown, A. Butterworth, C. Carrera, C. Carty, D. Chasman, Wei-Min Chen, J. Cole, A. Correa, I. Cotlarciuc, Carlos Cruchaga, J. Danesh, P. D. de Bakker, A. Destefano, M. den Hoed, Qing Duan, S. Engelter, G. Falcone, R. Gottesman, R. Grewal, V. Gudnason, S. Gustafsson, J. Haessler, T. Harris, Ahamad Hassan, A. Havulinna, S. Heckbert, E. Holliday, G. Howard, F. Hsu, Hyacinth I. Hyacinth, M. Ikram, E. Ingelsson, M. Irvin, X. Jian, J. Jiménez-Conde, Julie A. Johnson, J. Jukema, M. Kanai, Keith L. Keene, B. Kissela, D. Kleindorfer, C. Kooperberg, M. Kubo, L. Lange, C. Langefeld, C. Langenberg, L. Launer, J. Lee, R. Lemmens, D. Leys, C. Lewis, Wei-Yu Lin, A. Lindgren, E. Lorentzen, P. Magnusson, J. Maguire, A. Manichaikul, P. McArdle, J. Meschia, B. Mitchell, T. Mosley, M. Nalls, T. Ninomiya, M. O’Donnell, B. Psaty, S. Pulit, Kristiina Rannikmäe, A. Reiner, K. Rexrode, K. Rice, S. Rich, P. Ridker, N. Rost, P. Rothwell, J. Rotter, T. Rundek, R. Sacco, S. Sakaue, M. Sale, V. Salomaa, B. Sapkota, R. Schmidt, C. Schmidt, U. Schminke, Pankaj Sharma, A. Słowik, C. Sudlow, C. Tanislav, T. Tatlisumak, K. Taylor, V. Thijs, G. Thorleifsson, U. Thorsteinsdóttir, S. Tiedt, S. Trompet, C. Tzourio, C. V. van Duijn, M. Walters, N. Wareham, S. Wassertheil-Smoller, James G. Wilson, K. Wiggins, Qiong Yang, S. Yusuf, J. Bis, T. Pastinen, A. Ruusalepp, E. Schadt, Simon Koplev, J. Björkegren, Veronica Codoni, M. Civelek, N. Smith, D. Trégouët, I. Christophersen, C. Roselli, S. Lubitz, P. Ellinor, E. Tai, J. Kooner, N. Kato, Jiang He, P. van der Harst, P. Elliott, J. Chambers, F. Takeuchi, Andrew D. Johnson, D. Sanghera, O. Melander, C. Jern, D. Strbian, I. Férnandez-Cadenas, W. Longstreth, A. Rolfs, J. Hata, D. Woo, J. Rosand, G. Paré, J. Hopewell, D. Saleheen, K. Stefánsson, B. Worrall, S. Kittner, S. Seshadri, M. Fornage, H. Markus, J. Howson, Y. Kamatani, S. Debette, M. Dichgans   +170 more
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source