Results 161 to 170 of about 43,083,361 (310)

Clade Distillation for Genome-wide Association Studies

GENETICS
Abstract Testing inferred haplotype genealogies for association with phenotypes has been a longstanding goal in human genetics with several underlying challenges. A key advantage of these methods is the potential to detect association signals caused by allelic heterogeneity — when multiple causal variants modulate a phenotype — in both ...
Ryan Christ, Xinxin Wang, Louis J.M. Aslett, David Steinsaltz, Ira Hall   +4 more
openaire   +2 more sources

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.

, 2011
BACKGROUND: Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered.
Gibson, Lorna J, Lorna J. Gibson, Ross, Gillian, Peto, Julian, Gemma Simpson, Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, Minouk Schoemaker, Chanock, Stephen J., Williamson, Jill, Schoemaker, Minouk, Fay J. Hosking, Simpson, Gemma, Palles, Claire, Jill Williamson, Kevin B. Jacobs, Jacobs, Kevin B, Katarzyna Tomczyk, Gillian Ross, Alan Ashworth, Swerdlow, Anthony, Jones, Michael, Dos-Santos-Silva, Isabel, Stephen J. Chanock, Lathrop, Mark, Simon Heath, Sarah Chilcott-Burns, Isabel dos Santos Silva, Walker, Kate, dos Santos Silva, Isabel, Houlston, Richard S, Zelenika, Diana, Mark Lathrop, Nichola Johnson, Ben Coupland, David J. Hunter, Claire Palles, Ashworth, Alan, Kate Walker, Tomczyk, Katarzyna, Tomlinson, Ian P, Orr, Nick; id_orcid, Nick Orr, Peter Broderick, Orr, Nick, Swerdlow, Anthony J, Ivo Gut, Michael Jones, Diana Zelenika, Ian P. Tomlinson, Gut, Ivo, Chanock, Stephen J, Broderick, Peter, Chilcott-Burns, Sarah, Olivia Fletcher, Anthony Swerdlow, Walker-Springett, Kate, Richard S. Houlston, Hosking, Fay J, Heath, Simon, Julian Peto, Hunter, David J   +62 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI)Research in context

The Lancet Regional Health. Western Pacific
Summary: Background: The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians.
Chin-Hsien Lin, Chien-Ching Chang, Hung-Hsin Chen, Wan-Jia Lin, Chia-Lang Hsu, Rung-Juen Lin, Yi-Jen Guo, Ting-Chun Fang, Shinn-Zong Lin, Chih-Yang Huang, Shuu-Jiun Wang, Jen-Fan Hang, Sun-Wung Hsieh, Mei-Chuan Chou, Tu-Hsueh Yeh, Chaur-Jong Hu, Fu-Chi Yang, Hsin-An Chang, Tsong-Hai Lee, Meng-Han Tsai, Ming-Che Kuo, Jyh-Ming Liou, Ming-Shiang Wu, Kye Won Park, Sun Ju Chung, Eng-King Tan, Cathy Shen-Jang Fann   +26 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Genetic parameter estimation and molecular foundation of chicken egg-laying trait

Poultry Science
: The age of first egg (AFE) in chicken can affect early and even life-time egg production performance to some extent, and therefore is an important economic trait that affects production efficiency.
Anqi Chen, Xiaoyu Zhao, Junhui Wen, Xiurong Zhao, Gang Wang, Xinye Zhang, Xufang Ren, Yalan Zhang, Xue Cheng, Xiaofan Yu, Xiaohan Mei, Huie Wang, Menghan Guo, Xiaoyu Jiang, Guozhen Wei, Xue Wang, Runshen Jiang, Xing Guo, Zhonghua Ning, Lujiang Qu   +19 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The genetic aspects of multiple sclerosis

Annals of Indian Academy of Neurology, 2009
The epidemiology of multiple sclerosis has been extensively investigated and two features have consistently emerged: marked geographical variation in prevalence and substantial familial clustering. At first sight, geographic variation would seem to imply
Sawcer Stephen
doaj  

A genomic analysis of twinning rate and its relationship with other reproductive traits in Holstein-Friesian cattle

Journal of Dairy Science
: Twin births in dairy cattle is generally unfavorably associated with reproductive performance and calf survival in dairy cows. Genetic selection to reduce twinning rate in dairy cattle may be desirable, provided no undesirable correlated responses in ...
Brian W. Kirkpatrick, Donagh P. Berry
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source