Results 141 to 150 of about 40,713,960 (307)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Clade Distillation for Genome-wide Association Studies

GENETICS
Abstract Testing inferred haplotype genealogies for association with phenotypes has been a longstanding goal in human genetics with several underlying challenges. A key advantage of these methods is the potential to detect association signals caused by allelic heterogeneity — when multiple causal variants modulate a phenotype — in both ...
Ryan Christ, Xinxin Wang, Louis J.M. Aslett, David Steinsaltz, Ira Hall   +4 more
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.

, 2011
BACKGROUND: Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered.
Gibson, Lorna J, Jones, M, Tomlinson, IP, Ross, G, Lorna J. Gibson, Schoemaker, M, Lathrop, M, Ross, Gillian, Peto, Julian, Swerdlow, A, Gemma Simpson, Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, Hosking, FJ, Minouk Schoemaker, Chanock, Stephen J., Williamson, Jill, Zelenika, D, Schoemaker, Minouk, Coupland, B, Fay J. Hosking, Simpson, Gemma, Palles, Claire, Gut, I, Jill Williamson, Kevin B. Jacobs, Jacobs, Kevin B, Ashworth, A, Katarzyna Tomczyk, Houlston, RS, Johnson, N, Gillian Ross, Chanock, SJ, Alan Ashworth, Swerdlow, Anthony, Hunter, DJ, Jones, Michael, Chilcott-Burns, S, Dos-Santos-Silva, Isabel, Stephen J. Chanock, Lathrop, Mark, Williamson, J, Simon Heath, Broderick, P, Sarah Chilcott-Burns, Isabel dos Santos Silva, Walker, Kate, Fletcher, O, Heath, S, dos Santos Silva, Isabel, Houlston, Richard S, Zelenika, Diana, Mark Lathrop, Tomczyk, K, Nichola Johnson, Walker, K, Ben Coupland, David J. Hunter, Claire Palles, Palles, C, Ashworth, Alan, Kate Walker, Tomczyk, Katarzyna, Tomlinson, Ian P, Simpson, G, Orr, Nick; id_orcid, Nick Orr, Peter Broderick, Orr, Nick, Orr, N, Swerdlow, Anthony J, Ivo Gut, Peto, J, Tomlinson, Ian, Michael Jones, dos Santos Silva, I, Jacobs, KB, Diana Zelenika, Ian P. Tomlinson, Gut, Ivo, Chanock, Stephen J, Broderick, Peter, Chilcott-Burns, Sarah, Olivia Fletcher, Gibson, LJ, Anthony Swerdlow, Walker-Springett, Kate, Richard S. Houlston, Hosking, Fay J, Heath, Simon, Julian Peto, Hunter, David J   +92 more
core   +1 more source

Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI)Research in context

The Lancet Regional Health. Western Pacific
Summary: Background: The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians.
Chin-Hsien Lin, Chien-Ching Chang, Hung-Hsin Chen, Wan-Jia Lin, Chia-Lang Hsu, Rung-Juen Lin, Yi-Jen Guo, Ting-Chun Fang, Shinn-Zong Lin, Chih-Yang Huang, Shuu-Jiun Wang, Jen-Fan Hang, Sun-Wung Hsieh, Mei-Chuan Chou, Tu-Hsueh Yeh, Chaur-Jong Hu, Fu-Chi Yang, Hsin-An Chang, Tsong-Hai Lee, Meng-Han Tsai, Ming-Che Kuo, Jyh-Ming Liou, Ming-Shiang Wu, Kye Won Park, Sun Ju Chung, Eng-King Tan, Cathy Shen-Jang Fann   +26 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source