Results 1 to 10 of about 41,900,780 (178)

A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping. [PDF]

Genet Epidemiol, 2022
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants ...
Tapia AL, Rowland BT, Rosen JD, Preuss M, Young K, Graff M, Choquet H, Couper DJ, Buyske S, Bien SA, Jorgenson E, Kooperberg C, Loos RJF, Morrison AC, North KE, Yu B, Reiner AP, Li Y, Raffield LM.   +18 more
europepmc   +8 more sources

TIGAR-V2: Efficient TWAS tool with nonparametric Bayesian eQTL weights of 49 tissue types from GTEx V8

HGG Advances, 2022
Summary: Standard transcriptome-wide association study (TWAS) methods first train gene expression prediction models using reference transcriptomic data and then test the association between the predicted genetically regulated gene expression and ...
Randy L. Parrish, Greg C. Gibson, Michael P. Epstein, Jingjing Yang   +3 more
doaj   +3 more sources

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +3 more sources

Multi-ancestry Transcriptome-Wide Association Study (TWAS)-Informed Prioritization of Antipsychotic Metabolic Risk: Evaluation of GLP1R as a Shared Mechanistic Link. [PDF]

Cureus
Cheung N.
europepmc   +2 more sources

Polycomb-Focused Transcriptome-Wide Association Study (TWAS) Reveals a Neuronal Identity, Circuit-Maintenance, and Cellular-Logistics Architecture Linking Anorexia Nervosa and Binge-Eating Behaviour. [PDF]

Cureus
Cheung N, Cheung HK, Yu YW, Wu TT, Tsang YY.   +4 more
europepmc   +3 more sources

Mendelian randomization analysis of causal relationships between chondrosarcoma and angiogenesis related genes [PDF]

Discover Oncology
Objective To systematically explore causal relationships between chondrosarcoma and angiogenesis-related gene expression using Mendelian randomization (MR) and transcriptome-wide association study (TWAS) approaches, and identify potential therapeutic ...
Peng Xie, Xiangtao Bian, Wei Wei, Hai Teng, Chengbo Wang   +4 more
doaj   +2 more sources

Editorial: Statistical methods for genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) and their applications [PDF]

Frontiers in Genetics, 2023
Huiyan Sun, Qingrun Zhang, Zilong Zhang
exaly   +2 more sources

Transcriptome-Wide Association Studies (TWAS): Methodologies, Applications, and Challenges [PDF]

Current Protocols
Ela W. Knapik, Eric R. Gamazon, Anuar Konkashbaev   +2 more
exaly   +2 more sources

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis

Cells, 2022
Several genes associated with periodontitis have been identified through genome-wide association studies (GWAS); however, known genes only explain a minority of the estimated heritability.
Guirong Zhu, Xing Cui, Liwen Fan, Yongchu Pan, Lin Wang   +4 more
doaj   +1 more source

Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gut Pathogens, 2021
Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities.
Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang   +12 more
doaj   +1 more source