A large‐scale transcriptome‐wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine‐mapping [PDF]
Genetic Epidemiology, 2022 AbstractHematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome‐wide association studies (GWAS) have identified thousands of loci containing trait‐associated variants, the causal genes underlying these associations are often uncertain.
Bing Yu +2 more
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Integrative Multi-Omics Analysis Identifies Thrombosis-Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer. [PDF]
Chem Biol Drug DesIntegrative multi‐omics analysis identified thrombosis‐associated molecular features associated with prognosis and germline susceptibility‐related transcriptional programs in gastric cancer. ACTN2 and CRYAB emerged as candidate molecules linked to gastric cancer cell migration and invasion, with single‐cell analysis suggesting potential neutrophil ...
Lu X +7 more
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Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L. [PDF]
Adv Sci (Weinh)Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Chen L +12 more
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HGG Advances, 2022 Summary: Standard transcriptome-wide association study (TWAS) methods first train gene expression prediction models using reference transcriptomic data and then test the association between the predicted genetically regulated gene expression and ...
Randy L. Parrish +3 more
doaj +3 more sources
Frontiers in Genetics, 2020 Genome-wide association studies (GWAS) have identified multiple causal genes associated with amyotrophic lateral sclerosis (ALS); however, the genetic architecture of ALS remains completely unknown and a large number of causal genes have yet been ...
Lishun Xiao +7 more
doaj +3 more sources
TWAS atlas 2.0: an updated data resource for transcriptome-wide association studies
Nucleic Acids ResearchAbstract Transcriptome-wide association studies (TWAS), which combine large-scale GWAS and expression quantitative trait loci (eQTL) datasets to predict gene expression levels and identify trait-related genes, have recently been applied across many traits.
Jingyao Zeng, Jingfa Xiao, Si Zheng
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Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis. [PDF]
Cancer MedABSTRACT Background Clinical and epidemiological evidence has suggested a potential association between kidney dysfunction and bladder cancer (BC). One hypothesis for this comorbidity is the presence of a common genetic etiology. However, little is known about the shared genetics and causality of this association.
Lin Y +11 more
europepmc +2 more sources
Mendelian randomization analysis of causal relationships between chondrosarcoma and angiogenesis related genes [PDF]
Discover OncologyObjective To systematically explore causal relationships between chondrosarcoma and angiogenesis-related gene expression using Mendelian randomization (MR) and transcriptome-wide association study (TWAS) approaches, and identify potential therapeutic ...
Peng Xie +4 more
doaj +2 more sources
Multiancestry and Multitrait GWAS Meta-Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases. [PDF]
Genes Brain BehavThis study integrated GWAS data for schizophrenia from European (PGC, FinnGen, iPSYCH) and East Asian cohorts with GWAS of chronic pulmonary diseases (COPD, asthma, ILD, pneumonia) and lung function traits, alongside transcriptomic and proteomic datasets (GEO, GTEx, CommonMind, pQTL).
Ayoufu A +6 more
europepmc +2 more sources