Results 21 to 30 of about 2,884 (146)
Nature Communications, 2023 Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype ...
Xiaoyu Song +12 more
doaj +1 more source
Breast Cancer Research, 2022 Background Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However,
Hongjie Chen +56 more
doaj +1 more source
Abstract 30: Cross-cancer cross-tissue transcriptome-wide association study (TWAS) of 11 cancers identifies 56 novel genes [PDF]
Cancer Research, 2020 Abstract Although cancer is a heterogeneous disease, there are shared hallmark mechanisms across multiple tumor types. Because of this, identifying genes associated with multiple cancer types has the potential to shed light on general oncogenic mechanisms.
Helian Feng +20 more
openaire +1 more source
PLoS Genetics, 2021 Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene ...
Shizhen Tang +5 more
doaj +1 more source
PLoS ONE, 2022 Uterine fibroid is one of the most prevalent benign tumors in women, with high socioeconomic costs. Although genome-wide association studies (GWAS) have identified several loci associated with uterine fibroid risks, they could not successfully interpret ...
Gayeon Kim +6 more
doaj +2 more sources
On the interpretation of transcriptome-wide association studies.
PLoS Genetics, 2023 Transcriptome-wide association studies (TWAS) aim to detect relationships between gene expression and a phenotype, and are commonly used for secondary analysis of genome-wide association study (GWAS) results.
Christiaan de Leeuw +4 more
doaj +1 more source
Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis
Arthritis Research & Therapy, 2021 Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu +11 more
doaj +1 more source
The Plant Genome, 2022 Sweet corn (Zea mays L.) is consistently one of the most highly consumed vegetables in the United States, providing a valuable opportunity to increase nutrient intake through biofortification.
Jenna Hershberger +8 more
doaj +1 more source
UTMOST, A Novel Single And Cross-Tissue TWAS (Transcriptome Wide Association Study), Reveals New ASD (Autism Spectrum Disorder) Associated Genes [PDF]
, 2020 ABSTRACT Background ASD is a complex neurodevelopmental disorder which may significantly impact on the affected individual’s life. Common variation (SNPs) could explain about 50% of ASD heritability. Despite this fact and the large size of the last GWAS meta-analysis, it is believed that hundreds of ...
Cristina Rodriguez-Fontenla +1 more
openaire +1 more source
TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes
Scientific Reports, 2023 Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray +6 more
doaj +1 more source