Results 21 to 30 of about 41,900,780 (178)

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Nature Communications, 2023
Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype ...
Xiaoyu Song, Jiayi Ji, Joseph H. Rothstein, Stacey E. Alexeeff, Lori C. Sakoda, Adriana Sistig, Ninah Achacoso, Eric Jorgenson, Alice S. Whittemore, Robert J. Klein, Laurel A. Habel, Pei Wang, Weiva Sieh   +12 more
doaj   +1 more source

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]

, 2018
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Hyejung Won, Pasaniuc, Bogdan, Finucane, Hilary K., Geschwind, Daniel H., Katsanis, Nicholas, O'Donovan, Michael C., Kousi, Maria, Gusev, Alexander, Bogdan Pasaniuc, Sullivan, Patrick F., Yakir Reshef, Alkes L. Price, Daniel H. Geschwind, Gregory E. Crawford, Won, Hyejung, McCarroll, Steven, Reshef, Yakir, Crawford, Gregory E., Ophoff, Roel A., Nicholas Katsanis, Nicholas Mancuso, Mancuso, Nicholas, Safi, Alexias, Maria Kousi, Benjamin M. Neale, Price, Alkes L., Hilary K. Finucane, Steven McCarroll, Michael C. O’Donovan, O’Donovan, Michael C, Neale, Benjamin M., Geschwind, Daniel H, Sullivan, Patrick F, Crawford, Gregory E, Lingyun Song, Price, Alkes L, Song, Lingyun, null null, Ophoff, Roel A, Alexias Safi, Patrick F. Sullivan, Alexander Gusev, Neale, Benjamin M, Finucane, Hilary K, Roel A. Ophoff, Kousi, M, Safi, A, McCarroll, S, Finucane, HK, Mancuso, N, Song, L, Gusev, A, Reshef, Y, Won, H, Neale, BM   +54 more
core   +5 more sources

XingyiGuo/TF-TWAS: TF-TWAS

, 2022
TF-TWAS is a tool integrating susceptible transcription factor occupancy with transcriptome-wide association studies (TWAS) to identify susceptibility genes in human cancers and non-cancer ...
Guo Lab at VUMC
core   +1 more source

TWAS-GKF: a novel method for causal gene identification in transcriptome-wide association studies with knockoff inference [PDF]

Motivation: Transcriptome-wide association study (TWAS) aims to identify trait-associated genes regulated by significant variants to explore the underlying biological mechanisms at a tissue-specific level.
Anqi Wang, Peixin Tian, Yan Zhang
openalex   +2 more sources

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia.

PLoS Genetics, 2021
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene ...
Shizhen Tang, Aron S Buchman, Philip L De Jager, David A Bennett, Michael P Epstein, Jingjing Yang   +5 more
doaj   +1 more source

Additional file 3 of Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis

, 2023
Additional file 3: Table S1 Top genes selected by transcriptome-wide association study (TWAS ...
Menghao Teng (16939097), Xiaochen Su (16939091), Wenchen Ji (16939100), Anfa Chen (16939094), Yingang Zhang (451687)   +4 more
core   +1 more source

A transcriptome-wide association study of uterine fibroids to identify potential genetic markers and toxic chemicals

PLoS ONE, 2022
Uterine fibroid is one of the most prevalent benign tumors in women, with high socioeconomic costs. Although genome-wide association studies (GWAS) have identified several loci associated with uterine fibroid risks, they could not successfully interpret ...
Gayeon Kim, Gyuyeon Jang, Jaeseung Song, Daeun Kim, Sora Lee, Jong Wha J. Joo, Wonhee Jang   +6 more
doaj   +2 more sources

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Transcriptome‐wide association and prediction for carotenoids and tocochromanols in fresh sweet corn kernels

The Plant Genome, 2022
Sweet corn (Zea mays L.) is consistently one of the most highly consumed vegetables in the United States, providing a valuable opportunity to increase nutrient intake through biofortification.
Jenna Hershberger, Ryokei Tanaka, Joshua C. Wood, Nicholas Kaczmar, Di Wu, John P. Hamilton, Dean DellaPenna, C. Robin Buell, Michael A. Gore   +8 more
doaj   +1 more source

Multiple-Tissue Integrative Transcriptome-Wide Association Studies Discovered New Genes Associated With Amyotrophic Lateral Sclerosis

Frontiers in Genetics, 2020
Genome-wide association studies (GWAS) have identified multiple causal genes associated with amyotrophic lateral sclerosis (ALS); however, the genetic architecture of ALS remains completely unknown and a large number of causal genes have yet been ...
Lishun Xiao, Zhongshang Yuan, Siyi Jin, Ting Wang, Shuiping Huang, Shuiping Huang, Ping Zeng, Ping Zeng   +7 more
doaj   +1 more source