Results 1 to 10 of about 6,539 (115)

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults

PLoS Genetics, 2021
As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing.
Binglan Li, Marylyn D Ritchie, Roy Gulick   +2 more
exaly   +2 more sources

Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementia

PLoS Genetics, 2021
Transcriptome-wide association studies (TWAS) have been widely used to integrate transcriptomic and genetic data to study complex human diseases. Within a test dataset lacking transcriptomic data, traditional two-stage TWAS methods first impute gene ...
Michael Epstein, Shizhen Tang, Jingjing Yang   +2 more
exaly   +2 more sources

Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer’s disease dementia [PDF]

Communications Biology
Most existing transcriptome wide association studies (TWASs) of Alzheimer’s Disease (AD) dementia only use bulk RNA-seq data and a single statistical method.
Qiang Liu, Randy L. Parrish, Shizhen Tang, Shinya Tasaki, David A. Bennett, Nicholas T. Seyfried, Philip L. De Jager, Vilas Menon, Aron S. Buchman, Jingjing Yang   +9 more
doaj   +2 more sources

CFD+CD14+ monocytes: potential pathogenic subset in myasthenia gravis uncovered by multi-omics integration and machine learning analysis [PDF]

Frontiers in Immunology
BackgroundTranscriptome−wide association study (TWAS) contributes to discovering novel susceptibility genes related to diseases. Single-cell RNA sequencing (scRNA-seq) has been extensively applied to characterize cellular heterogeneity in various ...
Shuang Li, Yifan Zhang, Chenlu Hou, Chenlu Hou, Ting Chang   +4 more
doaj   +2 more sources

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source

On the interpretation of transcriptome-wide association studies.

PLoS Genetics, 2023
Transcriptome-wide association studies (TWAS) aim to detect relationships between gene expression and a phenotype, and are commonly used for secondary analysis of genome-wide association study (GWAS) results.
Christiaan de Leeuw, Josefin Werme, Jeanne E Savage, Wouter J Peyrot, Danielle Posthuma   +4 more
doaj   +1 more source

Power analysis of transcriptome-wide association study: Implications for practical protocol choice.

PLoS Genetics, 2021
The transcriptome-wide association study (TWAS) has emerged as one of several promising techniques for integrating multi-scale 'omics' data into traditional genome-wide association studies (GWAS).
Chen Cao, Bowei Ding, Qing Li, Devin Kwok, Jingjing Wu, Quan Long   +5 more
doaj   +1 more source

Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis

Arthritis Research & Therapy, 2021
Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen, Feng Zhang   +11 more
doaj   +1 more source

Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis

Journal of Orthopaedic Surgery and Research, 2023
Background Spondyloarthritis (SpA) is a group of multifactorial bone diseases influenced by genetic factors, the environment and lifestyle. However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic ...
Xiaochen Su, Anfa Chen, Menghao Teng, Wenchen Ji, Yingang Zhang   +4 more
doaj   +1 more source

Integrating Transcriptome-Wide Association Study and mRNA Expression Profiling Identifies Novel Genes Associated With Osteonecrosis of the Femoral Head

Frontiers in Genetics, 2021
ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma, Peilin Li, Li Liu, Shiqiang Cheng, Bolun Cheng, Chu Jun Liang, Sijia Tan, Wenyu Li, Yan Wen, Xiong Guo, Cuiyan Wu   +10 more
doaj   +1 more source