Results 11 to 20 of about 10,897 (225)
Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L. [PDF]
Adv Sci (Weinh)Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Chen L +12 more
europepmc +2 more sources
FABIO: TWAS fine-mapping to prioritize causal genes for binary traits.
PLoS GeneticsTranscriptome-wide association studies (TWAS) have emerged as a powerful tool for identifying gene-trait associations by integrating gene expression mapping studies with genome-wide association studies (GWAS). While most existing TWAS approaches focus on
Haihan Zhang +4 more
doaj +2 more sources
Integrative Multi-Omics Analysis Identifies Thrombosis-Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer. [PDF]
Chem Biol Drug DesIntegrative multi‐omics analysis identified thrombosis‐associated molecular features associated with prognosis and germline susceptibility‐related transcriptional programs in gastric cancer. ACTN2 and CRYAB emerged as candidate molecules linked to gastric cancer cell migration and invasion, with single‐cell analysis suggesting potential neutrophil ...
Lu X +7 more
europepmc +2 more sources
PLoS ONE, 2022 Uterine fibroid is one of the most prevalent benign tumors in women, with high socioeconomic costs. Although genome-wide association studies (GWAS) have identified several loci associated with uterine fibroid risks, they could not successfully interpret ...
Gayeon Kim +6 more
doaj +2 more sources
Arthritis Research & Therapy, 2021 Background Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life.
Jiawen Xu +6 more
doaj +1 more source
PLoS Genetics, 2021 Transcriptome-wide association studies (TWAS) test the association between traits and genetically predicted gene expression levels. The power of a TWAS depends in part on the strength of the correlation between a genetic predictor of gene expression and ...
Helian Feng +6 more
doaj +1 more source
Systematic Multi-Level Analyses Decode the Arthritis-Neurodegeneration Axis With In Vivo Validation. [PDF]
Adv Sci (Weinh)Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Wang J +7 more
europepmc +2 more sources
, 2022 TF-TWAS is a tool integrating susceptible transcription factor occupancy with transcriptome-wide association studies (TWAS) to identify susceptibility genes in human cancers and non-cancer ...
Guo Lab at VUMC
core +1 more source
Frontiers in Genetics, 2022 Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu +6 more
doaj +1 more source
Astronomy & Astrophysics, 2002 4 (journal) pages, 3 figures, accepted in A&A. (US Letter size)
Song, Inseok +2 more
openaire +2 more sources