Results 11 to 20 of about 56,647 (174)
Methods for Prioritizing Causal Genes in Molecular Studies of Human Disease: The State of the Art. [PDF]
Genet EpidemiolABSTRACT In the last decade, genome‐wide association studies (GWAS) have identified tens of thousands of common variants associated with a wide array of complex traits and diseases. Integration of GWAS with molecular data has informed the development of statistical tools for causal gene discovery.
Patasova K +4 more
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Transcriptome-wide association study identifies susceptibility genes for rheumatoid arthritis
Arthritis Research & Therapy, 2021 Objective To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data. Methods A transcriptome-wide association study (TWAS) was conducted by
Cuiyan Wu +11 more
doaj +1 more source
Frontiers in Genetics, 2021 ObjectiveThis study aims to identify novel candidate genes associated with osteonecrosis of the femoral head (ONFH).MethodsA transcriptome-wide association study (TWAS) was performed by integrating the genome-wide association study dataset of ...
Mei Ma +10 more
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PLoS ONE, 2022 Uterine fibroid is one of the most prevalent benign tumors in women, with high socioeconomic costs. Although genome-wide association studies (GWAS) have identified several loci associated with uterine fibroid risks, they could not successfully interpret ...
Gayeon Kim +6 more
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Journal of Orthopaedic Surgery and Research, 2023 Background Spondyloarthritis (SpA) is a group of multifactorial bone diseases influenced by genetic factors, the environment and lifestyle. However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic ...
Xiaochen Su +4 more
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Arthritis Research & Therapy, 2021 Background Osteoarthritis (OA) is a common skeletal system disease that has been partially attributed to genetic factors. The hand is frequently affected, which seriously affects the patient’s quality of life.
Jiawen Xu +6 more
doaj +1 more source
PLoS Genetics, 2021 Transcriptome-wide association studies (TWAS) test the association between traits and genetically predicted gene expression levels. The power of a TWAS depends in part on the strength of the correlation between a genetic predictor of gene expression and ...
Helian Feng +6 more
doaj +1 more source
Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture. [PDF]
J DiabetesFlowchart illustration. BMI: Body mass index; FG: Fasting glucose; vitamin D: Serum 25‐Hydroxyvitamin D levels; CKD: Chronic kidney disease; CAD: Coronary artery disease; T2D: Type 2 diabetes. ABSTRACT Background The genetic basis of cardiovascular‐kidney‐metabolic syndrome (CKMs) involves complex pleiotropy, necessitating analytical approaches capable
Lu C, Li L, Chen J, Chang R, Dong H.
europepmc +2 more sources
Frontiers in Genetics, 2022 Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu +6 more
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Microstructure and Flight Behaviors of Droplet and its Solidification in Twin-Wire Arc Sprayed Ni-Al Composite Coatings [PDF]
Materials Research, 2018 Droplet flight and solidification behaviors during twin-wire arc sprayed (TWAS) composite coatings were systematically investigated. Both theoretical model and numerical method were established for calculating the droplet deformation, breakup and ...
Jixiao Wang +7 more
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