CGSEA: A Flexible Tool for Evaluating the Associations of Chemicals with Complex Diseases [PDF]
G3: Genes, Genomes, Genetics, 2020 The etiology of many human complex diseases or traits involves interactions between chemicals and genes that regulate important physiological processes.
Shiqiang Cheng +10 more
doaj +8 more sources
Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis [PDF]
Frontiers in Endocrinology, 2022 Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased.
Mengnan Lu +6 more
doaj +3 more sources
Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis [PDF]
Arthritis Research & Therapy, 2023 Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.
Lin Mei +5 more
doaj +3 more sources
Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses [PDF]
Frontiers in Genetics, 2022 Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu +6 more
doaj +2 more sources
Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands [PDF]
, 2023 Rank signaling pathway regulates mammary gland homeostasis and epithelial cell differentiation. Although Rank receptor is expressed by basal cells and luminal progenitors, its role in each individual cell lineage remains unclear.
Collado-solé, Alejandro +7 more
core +2 more sources
Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy [PDF]
, 2020 Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly ...
Adair, Jennifer E. +16 more
core +1 more source
Early immune modulation by single-agent trastuzumab as a marker of trastuzumab benefit [PDF]
, 2018 BACKGROUND: Optimising the selection of HER2-targeted regimens by identifying subsets of HER2-positive breast cancer (BC) patients who need more or less therapy remains challenging.
Cappelletti, Maria Rosa +10 more
core +3 more sources
Network-driven strategies to integrate and exploit biomedical data [PDF]
, 2022 [eng] In the quest for understanding complex biological systems, the scientific community has been delving into protein, chemical and disease biology, populating biomedical databases with a wealth of data and knowledge.
Fernández Torras, Adrià
core +1 more source
The predictive power of sales seasonality over stock returns in the Asian stock markets [PDF]
, 2020 This paper examines the predictive power of sales seasonality over stock returns in the Asian stock markets from January 2004 to December 2019. I find that sales seasonality has predictive power over future stock returns because of time variation. A long-
Lehojärvi, Max
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