Results 31 to 40 of about 56,647 (174)

Integrative Transcriptome-Wide Analyses Uncover Novel Risk-Associated MicroRNAs in Hormone-Dependent Cancers

Frontiers in Genetics, 2021
BackgroundHormone-dependent cancers (HDC) are among the leading causes of death worldwide among both men and women. Some of the established risk factors of HDC include unhealthy lifestyles, environmental factors, and genetic influences.
Dulari K. Jayarathna, Dulari K. Jayarathna, Miguel E. Rentería, Miguel E. Rentería, Adil Malik, Adil Malik, Emilie Sauret, Jyotsna Batra, Jyotsna Batra, Neha S. Gandhi, Neha S. Gandhi   +10 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study

European Thyroid Journal
Introduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins, Rosalie B T M Sterenborg, Oleg Borisov, Nora Scherer, Yurong Cheng, Marco Medici, Anna Köttgen, Alexander Teumer   +7 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis

Frontiers in Genetics, 2020
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by a chronic, progressive, and irreversible decline in lung function. The genetic basis of IPF remains elusive.
Weiming Gong, Ping Guo, Lu Liu, Qingbo Guan, Qingbo Guan, Qingbo Guan, Zhongshang Yuan   +6 more
doaj   +1 more source

Supplemental Sewage Scum and Organic Municipal Solid Waste Addition to the Anaerobic Digestion of Thickened Waste Activated Sludge: Biomethane Potential and Microbiome Analysis

Fermentation, 2023
Sewage scum (SS) is collected from sedimentation tanks in wastewater treatment plants (WWTPs). Despite its huge biogas potential, there is limited information on its potential as a co-substrate and microbial ecology, especially during anaerobic co ...
Adewale Aromolaran, Majid Sartaj, Mohamed Abdallah   +2 more
doaj   +1 more source

Transcriptome-wide association studies: recent advances in methods, applications and available databases

Communications Biology, 2023
Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task.
Jialin Mai, Mingming Lu, Qianwen Gao, Jingyao Zeng, Jingfa Xiao   +4 more
doaj   +1 more source

Associations of Blood Pressure and Cholesterol Levels During Young Adulthood With Later Cardiovascular Events. [PDF]

, 2019
BackgroundBlood pressure (BP) and cholesterol are major modifiable risk factors for cardiovascular disease (CVD), but effects of exposures during young adulthood on later life CVD risk have not been well quantified.ObjectiveThe authors sought to evaluate
Allen, Norrina B, Alonso, Alvaro, Balte, Pallavi P, Bibbins-Domingo, Kirsten, de Ferranti, Sarah D, Gooding, Holly C, Ives, Diane G, Lloyd-Jones, Donald, Moran, Andrew E, Newman, Anne B, Oelsner, Elizabeth C, Pletcher, Mark J, Rana, Jamal S, Vasan, Ramachandran S, Vittinghoff, Eric, Yaffe, Kristine, Zeki Al Hazzouri, Adina, Zhang, Yiyi   +17 more
core   +1 more source

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Frontiers in Endocrinology, 2022
Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased.
Mengnan Lu, Ruoyang Feng, Yujie Qin, Hongyang Deng, Biyao Lian, Chunyan Yin, Yanfeng Xiao   +6 more
doaj   +1 more source

A Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Susceptibility Genes for Juvenile Idiopathic Arthritis in Asia and Europe

Frontiers in Immunology, 2022
BackgroundJuvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children, and its pathogenesis is still unclear. Genome-wide association studies (GWASs) of JIA have identified hundreds of risk factors, but few of them implicated ...
Jiawen Xu, Jun Ma, Yi Zeng, Haibo Si, Yuangang Wu, Shaoyun Zhang, Bin Shen   +6 more
doaj   +1 more source

Highly nondegenerate four-wave mixing and gain nonlinearity in a strained multiple-quantum-well optical amplifier [PDF]

, 1993
Highly nondegenerate four-wave mixing was investigated in a 1.5 µm compressively strained multi-quantum-well semiconductor traveling-wave optical amplifier at detuning frequencies up to 600 GHz.
Dawson, Jay W., Koren, Uziel, Miller, Barry I., Newkirk, Michael A., Park, Namkyoo, Vahala, Kerry J., Zhou, Jianhui   +6 more
core   +1 more source