Results 31 to 40 of about 11,154 (181)

A Manhattan plot of the TWAS results for UF.

, 2022
Each dot corresponds to the gene of which predicted expression is associated with UF. The X-axis denotes the chromosome numbers of the genes and the Y-axis denotes −log10(TWAS P-values). The yellow line indicates a Bonferroni significant threshold (P −6).
Jong Wha J. Joo (13883877), Sora Lee (382331), Wonhee Jang (1784002), Gayeon Kim (671557), Jaeseung Song (13883874), Gyuyeon Jang (13883871), Daeun Kim (4967644)   +6 more
core   +1 more source

New insights into the hypothalamic–pituitary– thyroid axis: a transcriptome- and proteome-wide association study

European Thyroid Journal
Introduction: Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues.
Sara Monteiro-Martins, Rosalie B T M Sterenborg, Oleg Borisov, Nora Scherer, Yurong Cheng, Marco Medici, Anna Köttgen, Alexander Teumer   +7 more
doaj   +1 more source

Integrative Transcriptome-Wide Analyses Uncover Novel Risk-Associated MicroRNAs in Hormone-Dependent Cancers

Frontiers in Genetics, 2021
BackgroundHormone-dependent cancers (HDC) are among the leading causes of death worldwide among both men and women. Some of the established risk factors of HDC include unhealthy lifestyles, environmental factors, and genetic influences.
Dulari K. Jayarathna, Dulari K. Jayarathna, Miguel E. Rentería, Miguel E. Rentería, Adil Malik, Adil Malik, Emilie Sauret, Jyotsna Batra, Jyotsna Batra, Neha S. Gandhi, Neha S. Gandhi   +10 more
doaj   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

Summary of TWAS standard error deflation values per gene.

, 2023
Summary of TWAS standard error deflation values per gene.
Josefin Werme (16949399), Wouter J. Peyrot (3965684), Danielle Posthuma (237783), Jeanne E. Savage (13256558), Christiaan de Leeuw (457984)   +4 more
core   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis

Frontiers in Genetics, 2020
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by a chronic, progressive, and irreversible decline in lung function. The genetic basis of IPF remains elusive.
Weiming Gong, Ping Guo, Lu Liu, Qingbo Guan, Qingbo Guan, Qingbo Guan, Zhongshang Yuan   +6 more
doaj   +1 more source

Supplemental Sewage Scum and Organic Municipal Solid Waste Addition to the Anaerobic Digestion of Thickened Waste Activated Sludge: Biomethane Potential and Microbiome Analysis

Fermentation, 2023
Sewage scum (SS) is collected from sedimentation tanks in wastewater treatment plants (WWTPs). Despite its huge biogas potential, there is limited information on its potential as a co-substrate and microbial ecology, especially during anaerobic co ...
Adewale Aromolaran, Majid Sartaj, Mohamed Abdallah   +2 more
doaj   +1 more source

TWAS association signals for prediXcan (single-tissue).

, 2022
TWAS results via metaXcan using prediXcan single tissue models derived from GTEx version 6 tissues (PDF)
Hyun Min Kang (9690325), Andrew E. Liu (12024808)   +1 more
core   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Circos plots showing how marginally significant TWAS gene lists (P < 0.05) for each of the eight eQTL panels overlap.

, 2022
On the outside, the arc represents the eight eQTL panels. On the inside, the dark orange arc represents genes shared by several panels and the light orange arc represents genes unique to those panels.
Jong Wha J. Joo (13883877), Sora Lee (382331), Wonhee Jang (1784002), Gayeon Kim (671557), Jaeseung Song (13883874), Gyuyeon Jang (13883871), Daeun Kim (4967644)   +6 more
core   +1 more source