Results 21 to 30 of about 56,647 (174)

Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

Arthritis Research & Therapy, 2023
Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren, Zhihong Li   +5 more
doaj   +1 more source

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution [PDF]

, 2017
We show that epigenome- and transcriptome-wide association studies (EWAS and TWAS) are prone to significant inflation and bias of test statistics, an unrecognized phenomenon introducing spurious findings if left unaddressed.
't Hoen, P.-B. (Peter-Bram), 't Hoen, P.A.C. (Peter A.C.), Arindrarto, W. (Wibowo), Beekman, M. (Marian), Berg, L.H. (Leonard) van den, Bonder, M.J. (Marc), Boomsma, D.I. (Dorret), Bot, J.J. (Jan), Breggen, R. (Ruud) van der, Deelen, J. (Joris), Deelen, P. (Patrick), Dijk, F. (Freerk) van, Dongen, J. (Jenny) van, Duijn, C.M. (Cornelia) van, Franke, L. (Lude), Greevenbroek, M.M. van, Heemst, D. (Diana) van, Heijmans, B.T. (Bastiaan), Hofman, B., Hottenga, J.J. (Jouke Jan), Isaacs, A.J. (Aaron), Iterson, M. (Maarten) van, Jansen, R., Jhamai, P.M. (Mila), Kallen, C.J. van der, Kielbasa, S.M. (Szymon M.), Lakenberg, N. (Nico), Luijk, R. (René), Mei, S. (Shan), Meurs, J.B.J. (Joyce) van, Moed, H. (Heleen), Nooren, I. (Irene), Pool, R. (Reńe), Rooij, J.G.J. (Jeroen) van, Schalkwijk, C.G. (Casper), Slagboom, P.E. (Eline), Stehouwer, C.D. (Coen), Suchiman, H.E.D. (Eka), Swertz, M.A. (Morris A.), Tigchelaar, E.F. (Ettje F.), Uitterlinden, A.G. (André), van 't Hof, P. (Peter), Van Galen, M. (Michiel), Veldink, J.H. (Jan), Verbiest, M.M.P.J. (Michael), Verkerk, M. (Marijn), Vermaat, M. (Martijn), Wijmenga, C. (Cisca), Zhernakova, A. (Alexandra), Zhernakova, S. (Sasha), Zwet, E.W. (Erik) van   +50 more
core   +1 more source

Regulation of labour market intermediaries and the role of social partners in preventing trafficking of labour [PDF]

, 2016
This report aims to contribute to the development of a best practice guide for public authorities on monitoring and enforcing rules and regulations relevant to labour market intermediaries to prevent trafficking for labour exploitation. The report brings
Clark, Nick, Fromm, Andrea, Paraskevopoulou, Anna   +2 more
core   +1 more source

SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identification

Nature Communications, 2022
Genes with moderate-low expression heritability cannot be sufficiently captured with conventional TWAS. This study introduces a new method, Summary-level Unified Method for Modeling Integrated Transcriptome (SUMMIT), to improve the expression prediction ...
Zichen Zhang, Ye Eun Bae, Jonathan R. Bradley, Lang Wu, Chong Wu   +4 more
doaj   +1 more source

De Rosis Nascentibus in English from the Renaissance to the Twentieth Century: a collection of translations [PDF]

, 2017
No abstract ...
Gillespie, Stuart
core   +1 more source

Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Arthritis Research & Therapy, 2023
Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogenesis is unclear.
Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu, Peng Xu   +5 more
doaj   +1 more source

Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity [PDF]

, 2017
JRS was supported by the 1000 talents program and a Wolfson merit award from the Royal Sociey.
Mazidi, Mohsen, Speakman, John R
core   +1 more source

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights [PDF]

, 2018
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 ...
Crawford, Gregory E, Finucane, Hilary K, Geschwind, Daniel H, Gusev, Alexander, Katsanis, Nicholas, Kousi, Maria, Mancuso, Nicholas, McCarroll, Steven, Neale, Benjamin M, O'Donovan, Michael C, Ophoff, Roel A, Pasaniuc, Bogdan, Price, Alkes L, Reshef, Yakir, Safi, Alexias, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Song, Lingyun, Sullivan, Patrick F, Won, Hyejung   +18 more
core   +2 more sources

TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes

Scientific Reports, 2023
Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray, Vikas Vohra, Vishakha Uttam, Ameya Santhosh, Punjika Saxena, Rajesh Kumar Gahlyan, Gopal Gowane   +6 more
doaj   +1 more source

2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]

, 2018
The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin, Xu, Shizhong, Zhang, Wenchao, Zhao, Patrick X   +3 more
core   +2 more sources