Results 21 to 30 of about 11,154 (181)

Microstructure and Flight Behaviors of Droplet and its Solidification in Twin-Wire Arc Sprayed Ni-Al Composite Coatings [PDF]

Materials Research, 2018
Droplet flight and solidification behaviors during twin-wire arc sprayed (TWAS) composite coatings were systematically investigated. Both theoretical model and numerical method were established for calculating the droplet deformation, breakup and ...
Jixiao Wang, Yongdong Wang, Jingshun Liu, Lunyong Zhang, Limin Gao, Guanghai Zheng, Hongxian Shen, Jianfei Sun   +7 more
doaj   +2 more sources

Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis

Arthritis Research & Therapy, 2023
Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.
Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren, Zhihong Li   +5 more
doaj   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L. [PDF]

Adv Sci (Weinh)
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Chen L, Zhang Y, Ma X, Bi J, He F, Zhao L, Lei H, Xiao Z, Wang X, Zhang T, Long R, Kang J, Yang Q.   +12 more
europepmc   +2 more sources

TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes

Scientific Reports, 2023
Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray, Vikas Vohra, Vishakha Uttam, Ameya Santhosh, Punjika Saxena, Rajesh Kumar Gahlyan, Gopal Gowane   +6 more
doaj   +1 more source

A large-scale transcriptome-wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine-mapping [PDF]

, 2022
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants ...
Rowland, B.T., Tapia, A.L., Preuss, M., Raffield, L.M., Jorgenson, E., Li, Y., Couper, D.J., Kooperberg, C., Morrison, A.C., Loos, R.J.F., North, K.E., Bien, S.A., Rosen, J.D., Young, K., Graff, M., Yu, B., Reiner, A.P., Choquet, H., Buyske, S.   +18 more
core   +1 more source

SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identification

Nature Communications, 2022
Genes with moderate-low expression heritability cannot be sufficiently captured with conventional TWAS. This study introduces a new method, Summary-level Unified Method for Modeling Integrated Transcriptome (SUMMIT), to improve the expression prediction ...
Zichen Zhang, Ye Eun Bae, Jonathan R. Bradley, Lang Wu, Chong Wu   +4 more
doaj   +1 more source

A large‐scale transcriptome‐wide association study (TWAS) of 10 blood cell phenotypes reveals complexities of TWAS fine‐mapping [PDF]

, 2021
Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genomewide association studies (GWAS) have identified thousands of loci containing trait-associated variants, the
David J. Couper, Kari E. North, Couper, David J., Rowland, Bryce T, Li, Yun, Raffield, Laura M, Hélène Choquet, Stephanie A. Bien, Choquet, Hélène, Michael Preuss, Yun Li, Jonathan D. Rosen, North, Kari E, Preuss, Michael, Buyske, Steve, Loos, Ruth J F, Steve Buyske, Couper, David J, Rosen, Jonathan D, Bien, Stephanie A, Raffield, Laura M., Alanna C. Morrison, Bryce T. Rowland, Young, Kris, Morrison, Alanna C, Ruth J. F. Loos, Loos, Ruth J. F., Misa Graff, Eric Jorgenson, Morrison, Alanna C., Yu, Bing, Kooperberg, Charles, Charles Kooperberg, Laura M. Raffield, Rowland, Bryce T., Bien, Stephanie A., North, Kari E., Tapia, Amanda L., Amanda L. Tapia, Kris Young, Tapia, Amanda L, Jorgenson, Eric, Graff, Misa, Alexander P. Reiner, Reiner, Alexander P, Bing Yu, Reiner, Alexander P., Rosen, Jonathan D.   +47 more
core   +1 more source

Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Arthritis Research & Therapy, 2023
Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogenesis is unclear.
Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu, Peng Xu   +5 more
doaj   +1 more source

Chemotherapy Toxicity TWAS Summary Statistics

, 2020
TWAS Summary ...
Ashley Mulford
core   +1 more source

Overview of available TWAS analysis methods.

, 2023
Transcriptome-wide association studies (TWAS) aim to detect relationships between gene expression and a phenotype, and are commonly used for secondary analysis of genome-wide association study (GWAS) results.
Josefin Werme (16949399), Wouter J. Peyrot (3965684), Danielle Posthuma (237783), Jeanne E. Savage (13256558), Christiaan de Leeuw (457984)   +4 more
core   +1 more source