Results 41 to 50 of about 8,098 (241)

Transcriptome-wide association studies: recent advances in methods, applications and available databases

Communications Biology, 2023
Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task.
Jialin Mai, Mingming Lu, Qianwen Gao, Jingyao Zeng, Jingfa Xiao   +4 more
doaj   +1 more source

From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries

Frontiers in Genetics, 2021
Since their inception, genome-wide association studies (GWAS) have identified more than a hundred thousand single nucleotide polymorphism (SNP) loci that are associated with various complex human diseases or traits.
Binglan Li, Marylyn D. Ritchie, Marylyn D. Ritchie   +2 more
doaj   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Science for All? A Systematic Literature Review on Effective Teaching Approaches in Inclusive and Separate Settings

Science Education, EarlyView.
ABSTRACT This systematic literature review examines intervention studies focused on teaching science to a diverse range of learners. It adopts a broad definition of inclusion and makes use of the PRISMA statement. The review aims to provide an overview of evidence‐based teaching approaches in the current literature, identify the science skills targeted,
Silvia Fränkel, Nadine Großmann, Melanie Basten   +2 more
wiley   +1 more source

Metrology for Quantum Hardware Standardization—Charting a Pathway: A Strategic Review

IEEJ Transactions on Electrical and Electronic Engineering, EarlyView.
Advances in quantum mechanics have long underpinned metrology by enabling practical realizations of units through quantum effects. With the 2019 SI revision, traceability is anchored in defined fundamental constants, reinforcing the quantum‐mechanical basis of modern standards. In parallel, quantum technologies are transitioning from laboratory science
Nobu‐Hisa Kaneko
wiley   +1 more source

From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
doaj   +1 more source

Reassessing Environmental Performance Within ESG Frameworks: Efficiency‐Based Evidence From Multinational Firms

Thunderbird International Business Review, EarlyView.
ABSTRACT The paper explores the evolving relationship between decarbonization strategies, environmental performance within ESG frameworks, and the economic performance of multinational companies in the context of increasing environmental and geopolitical uncertainty.
Maurizio Pompella, Lorenzo Costantino
wiley   +1 more source

Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies

Arthritis Research & Therapy, 2019
Background Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.
Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang, Feng Zhang   +9 more
doaj   +1 more source

A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk

Frontiers in Genetics, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression.
Nicholas B. Larson, Shannon K. McDonnell, Zachary Fogarty, Yuanhang Liu, Amy J. French, Lori S. Tillmans, John C. Cheville, Liang Wang, Daniel J. Schaid, Stephen N. Thibodeau   +9 more
doaj   +1 more source

Bound by blood and bloodshed: Sibling ties and participation in genocidal violence

Criminology, EarlyView.
Abstract Focusing on the 1994 genocide in Rwanda, we examine how sibling relationships—one of the most salient familial bonds—influence individual engagement in violence during mass atrocity. Drawing on an adaptation of differential association and social learning theories for contexts of mass atrocity, we analyze a novel dataset linking over 300,000 ...
Jack G. R. Wippell, Hollie Nyseth Nzitatira, Jared F. Edgerton, Evelyn Gertz   +3 more
wiley   +1 more source