Results 41 to 50 of about 11,154 (181)

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis [PDF]

Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes.
Zhang, Zhenyang, Gao, Yahui, Pan, Yuchun, Fang, Lingzhao, Liu, Shuli, Zhang, Zhe, Teng, Jinyan, Li, Bingjie; id_orcid, Lin, Qing, Wu, Jun, Chen, Zitao, Bai, Zhonghao, Liu, George, Wang, Qishan   +13 more
core   +1 more source

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome.
Shuyi Guo, Jingjing Yang
doaj   +1 more source

Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis

Frontiers in Endocrinology, 2022
Menarche is the first occurrence of menstrual bleeding and one of the most important events of female puberty. Alarmingly, over the last several decades, the mean age at menarche (AAM) has decreased.
Mengnan Lu, Ruoyang Feng, Yujie Qin, Hongyang Deng, Biyao Lian, Chunyan Yin, Yanfeng Xiao   +6 more
doaj   +1 more source

A Review on Current Challenges and Knowledge Gaps in Artificial Stone Silicosis

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background The global emergence of artificial stone (AS) silicosis represents a critical occupational health challenge. The aim of this systematic review is to provide an overview of the clinical, functional, radiological, and occupational characteristics of patients affected by AS silicosis at the time of diagnosis, and to identify current ...
Paola Mason, Marco Biasioli, Filippo Liviero, Mariella Carrieri, Maria Luisa Scapellato, Vincenzo Baldo, Shivonne Prasad, Dunya Tomic, Ryan Hoy   +8 more
wiley   +1 more source

Functional annotation networks consisting of biological pathways enriched with TWAS genes for UF.

, 2022
(A) Four major clusters grouped into three parental biological pathways were enriched with positively associated TWAS genes (TWAS P-value 0). (B) Four major clusters of biological pathways were enriched with negatively associated TWAS genes (TWAS P ...
Jong Wha J. Joo (13883877), Sora Lee (382331), Wonhee Jang (1784002), Gayeon Kim (671557), Jaeseung Song (13883874), Gyuyeon Jang (13883871), Daeun Kim (4967644)   +6 more
core   +1 more source

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Nature Communications, 2023
Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype ...
Xiaoyu Song, Jiayi Ji, Joseph H. Rothstein, Stacey E. Alexeeff, Lori C. Sakoda, Adriana Sistig, Ninah Achacoso, Eric Jorgenson, Alice S. Whittemore, Robert J. Klein, Laurel A. Habel, Pei Wang, Weiva Sieh   +12 more
doaj   +1 more source

A Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Susceptibility Genes for Juvenile Idiopathic Arthritis in Asia and Europe

Frontiers in Immunology, 2022
BackgroundJuvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children, and its pathogenesis is still unclear. Genome-wide association studies (GWASs) of JIA have identified hundreds of risk factors, but few of them implicated ...
Jiawen Xu, Jun Ma, Yi Zeng, Haibo Si, Yuangang Wu, Shaoyun Zhang, Bin Shen   +6 more
doaj   +1 more source

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Nature Communications, 2023
Alternative polyadenylation (APA) contributes to the post-transcriptional regulation of most human genes, yet the effects of APA are largely overlooked by conventional transcriptome-wide association studies (TWAS).
Ya Cui, Frederick J. Arnold, Fanglue Peng, Dan Wang, Jason Sheng Li, Sebastian Michels, Eric J. Wagner, Albert R. La Spada, Wei Li   +8 more
doaj   +1 more source

Shared Genetic Pathways Linking Oral Diseases to Gastrointestinal Disorders: An Integrative Multi‐Omics Study

iMetaMed, EarlyView.
Shared genetics pathways connect oral diseases and gut disorders. ABSTRACT Oral diseases are highly prevalent and increasingly recognized as contributors to gastrointestinal disorders. Despite clinical observations of oral–gut comorbidity, the underlying genetic architecture and causal mechanisms remain poorly understood.
Rui Zhang, Yuelan Gao, Yuyang Zhao, Wanyang Zhong, Xingxiang Duan, Yan He, Qingsong Ye   +6 more
wiley   +1 more source