Results 61 to 70 of about 8,098 (241)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Multiple-Tissue Integrative Transcriptome-Wide Association Studies Discovered New Genes Associated With Amyotrophic Lateral Sclerosis

Frontiers in Genetics, 2020
Genome-wide association studies (GWAS) have identified multiple causal genes associated with amyotrophic lateral sclerosis (ALS); however, the genetic architecture of ALS remains completely unknown and a large number of causal genes have yet been ...
Lishun Xiao, Zhongshang Yuan, Siyi Jin, Ting Wang, Shuiping Huang, Shuiping Huang, Ping Zeng, Ping Zeng   +7 more
doaj   +1 more source

Inhibition of Staphylococcus aureus Biofilm Formation by Plumbagin Combined With Ceftazidime and Cefazolin

eFood, Volume 7, Issue 4, August 2026.
Plumbagin can be potentially used in combination with antibiotics, as a safer, and effective agent solution against biofilms formed by Staphylococcus aureus in the healthcare, and food industry. ABSTRACT Biofilm‐forming Staphylococcus aureus is the major cause several foodborne diseases, and pose a serious challenge in the healthcare, and food industry.
Borel Ndezo Bisso, Humera Jahan, Akim Socohou, Mamadou Sawadogo, Jean Paul Dzoyem, M. Iqbal Choudhary   +5 more
wiley   +1 more source

R1 Prognostic Significance of T‐Wave Amplitude Variability for Adverse Cardiovascular Outcomes: A Systematic Review and Meta‐Analysis

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
In this systematic review and meta‐analysis of seven studies involving 1366 patients, elevated T‐wave amplitude variability (TAV) was associated with a 2.5‐fold higher risk of adverse cardiovascular outcomes. These findings support TAV as a marker of ventricular repolarization instability for long‐term risk stratification.
Yoshihiro Sobue, Kazuya Takeda, Mari Amino, Koichiro Yoshioka, Tomohide Ichikawa, Eiichi Watanabe   +5 more
wiley   +1 more source

MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies

Genome Biology
Transcriptome-wide association study (TWAS) has emerged as a powerful tool for translating the myriad variations identified by genome-wide association studies (GWAS) into regulated genes in the post-GWAS era.
Han Wang, Xiang Li, Teng Li, Zhe Li, Pak Chung Sham, Yan Dora Zhang   +5 more
doaj   +1 more source

Mechanisms of Resistance, Insights From Case Reports, and Future Prospects in Mycobacteriophage Therapy

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Evolution of drug‐resistant mycobacterial infections warrants renewed efforts in identifying more efficient preventive and control strategies as well as alternative treatment options. Interest in phage therapy is regaining significant traction, especially in cases of failed conventional therapy.
Buhari Yusuf, Abdul Malik, Md Shah Alam, Lijie Li, Haftay Abraha Tadesse, Aweke Mulu Belachew, Cuiting Fang, Xirong Tian, Htin Lin Aung, Shuai Wang, Tianyu Zhang   +10 more
wiley   +1 more source

Secular Trend in Glycaemic Management in Type 2 Diabetes Patients With and Without Cirrhosis Between 2000 and 2023: A Territory‐Wide Cohort Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 3, Page 356-366, August 2026.
In this territory‐wide cohort study, improving glycemic control can be observed regardless of cirrhosis status. Oral antidiabetic medication was more often used in the non‐cirrhosis group, and insulin was preferred in patients with decompensated cirrhosis, who exhibited an increasing incidence of hypoglycemia over the years and need individualized ...
Mary Yue Wang, Sherlot Juan Song, Nana Peng, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong, Jimmy Che‐To Lai, Terry Cheuk‐Fung Yip   +6 more
wiley   +1 more source

Transcriptome-Wide Association Supplements Genome-Wide Association in Zea mays

G3: Genes, Genomes, Genetics, 2019
Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.
Karl A. G. Kremling, Christine H. Diepenbrock, Michael A. Gore, Edward S. Buckler, Nonoy B. Bandillo   +4 more
doaj   +1 more source

Potential Functions and Causal Associations of GNLY in Primary Open-Angle Glaucoma: Integration of Blood-Derived Proteome, Transcriptome, and Experimental Verification

Journal of Inflammation Research
Dangdang Wang,1,2,* Yanyu Pu,1,2,* Xi Gao,1,2 Lihong Zeng,1,2 Hong Li1,2 1Department of Ophthalmology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Chongqing Key Laboratory for the ...
Wang D, Pu Y, Gao X, Zeng L, Li H
doaj  

Multiancestry and Multitrait GWAS Meta‐Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases

Genes, Brain and Behavior, Volume 25, Issue 4, August 2026.
This study integrated GWAS data for schizophrenia from European (PGC, FinnGen, iPSYCH) and East Asian cohorts with GWAS of chronic pulmonary diseases (COPD, asthma, ILD, pneumonia) and lung function traits, alongside transcriptomic and proteomic datasets (GEO, GTEx, CommonMind, pQTL).
Abudusalamu Ayoufu, Ayinigeer Abulimiti, Wusimanjiang Aierken, ZhouBin Wei, XueCheng Wang, HaiFeng Wang, Liang Zhao   +6 more
wiley   +1 more source