Results 61 to 70 of about 11,154 (181)

Ancestry-specific TWAS refines type 2 diabetes GWAS loci in disease-relevant tissues

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia and insulin resistance. Although genome-wide association studies (GWAS) have identified >600 T2D risk loci, the causal genes and the relevant tissues mediating these ...
Pagnuco I, Eyre S, Rattray M, Morris AP.
europepmc   +2 more sources

Alternative Contract Design: Analysing the Bankability of Fungible Derivative Contracts in Energy‐Only Markets

Australian Journal of Agricultural and Resource Economics, EarlyView.
ABSTRACT With the retirement of 21GW of legacy coal fleet looming, the task to replace Australia's thermal capacity with alternative firmed renewable ‘bulk energy’ solutions is non‐trivial. Indeed, calibrating necessary capital investment in new plant stock with efficient economic outcomes, vis‐à‐vis cost and reliability, represents a fundamental ...
Nicholas Gohdes, Tim Nelson, Phillip Hirschhorn   +2 more
wiley   +1 more source

Atomization Characteristics of Droplet and Morphologies of Arc Sprayed Ni-Al Particles and Composition Coatings [PDF]

Materials Research, 2019
Droplet atomization characteristics and its morphology in twin-wire arc sprayed (TWAS) Ni-Al were explored in depth. Both numerical model and theoretical method were built for calculating the process of the droplet deformation and breakup in air flow ...
Jixiao Wang, Jun Wang, Guo Jin, Li Wang, Caisong Mo, Li Ma, Bairu Li, Yongdong Wang, Hongxian Shen, Xing Lu, Yunzhuo Lv, Siyu Yuan, Jian Zhang, Yongjiang Huang, Fuyang Cao, Jianfei Sun   +15 more
doaj   +1 more source

Electricity Retailer Hedging Using Fungible Financial Renewable Energy Contracts

Australian Journal of Agricultural and Resource Economics, EarlyView.
ABSTRACT In energy‐only electricity markets, such as the Australian National Electricity Market (NEM), all electricity is bought and sold within the spot market and energy retailers hedge their load using financial contracts. These interrelated markets are key aspects of the NEM design.
Jonty Flottmann, Philip Hirschhorn, Tim Nelson   +2 more
wiley   +1 more source

XingyiGuo/transTF-TWAS: TransTF-TWAS

<p>Transcriptome-wide association studies (TWAS) have been successful in identifying disease susceptibility genes by integrating cis-variants predicted gene expression with genome-wide association studies (GWAS) data, while trans-located variants ...
Guo Lab at VUMC
core   +1 more source

Leveraging genomic and transcriptomic data of diverse ancestry to uncover mechanisms of psychiatric risk in the adult and developing brain

Nature Communications
We explore strategies to harness ancestral diversity in PsychENCODE Consortium Genotype-Expression (GEx) reference panels (adult and developing brain) and Psychiatric Genomics Consortium GWAS data to improve genetically regulated expression (GReX) models
Aarti Jajoo, Vijetha Balakundi, Chris Chatzinakos, Athina Aruldass, Cindy Wen, Ilse G. C. Kolmans, Artemis Iatrou, Joel E. Kleinman, Kerry J. Ressler, Tim Bigdeli, Michael J. Gandal, Nikolaos P. Daskalakis   +11 more
doaj   +1 more source

Multi-context genetic modeling of transcriptional regulation resolves novel disease loci

Nature Communications, 2022
Transcriptome-wide association studies (TWAS) often ignore the specificity and sharing of effects across contexts (e.g., tissues). Here, the authors describe a method to split genetic effects into context-shared and context-specific terms.
Mike Thompson, Mary Grace Gordon, Andrew Lu, Anchit Tandon, Eran Halperin, Alexander Gusev, Chun Jimmie Ye, Brunilda Balliu, Noah Zaitlen   +8 more
doaj   +1 more source

‘A Fairly Average “White Middle‐Class” Species of Lesbian’: Lorna Gulston, Ireland and the Early Anglophone Lesbian Press, 1965–1980

Gender &History, EarlyView.
ABSTRACT This article examines the published writings of Lorna Gulston (c. 1932–2023), a hitherto unknown Northern Irish civil servant who wrote many articles for the earliest British lesbian magazines such as Arena Three, Sappho and Sequel. In doing so, the article asks: How did Gulston find her way onto the pages of these pioneering magazines?
Maurice J. Casey
wiley   +1 more source

Intra‐operative hypotension threshold models and subdistribution hazard of postoperative pneumonia in patients having non‐cardiac surgery

Anaesthesia, EarlyView.
Summary Introduction Intra‐operative hypotension is common during general anaesthesia, but its association with postoperative pneumonia remains uncertain, partly because hypotension has been defined using different thresholds. We evaluated whether absolute thresholds or relative reductions from baseline mean arterial pressure were associated more ...
Pingping Wang, Junming Gu, Yanyu Liu, Jing Zhuang, Shengkun Peng, Qian Xiang, Minhong Cai, Xiaobin Liu, Yu Lv   +8 more
wiley   +1 more source

Occasion and audience as poetic constructs in early modern occasional poetry

Orbis Litterarum, EarlyView.
Abstract Occasional poetry, composed for specific events such as weddings or funerals, was a dominant form of poetry in early modern Europe. Despite its historical prominence, the role of the occasion as a literary and rhetorical construct in occasional poetry has been very little studied.
Eeva‐Liisa Bastman
wiley   +1 more source