Results 71 to 80 of about 8,098 (241)

TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies [PDF]

, 2022
Mingming Lu, Yadong Zhang, Fengchun Yang, Jialin Mai, Qianwen Gao, Xiaowei Xu, Hongyu Kang, Li Hou, Yunfei Shang, Qiheng Qain, Jie Liu, Meiye Jiang, Hao Zhang, Congfan Bu, Jinyue Wang, Zhewen Zhang, Zaichao Zhang, Jingyao Zeng, Jiao Li, Jingfa Xiao   +19 more
openalex   +1 more source

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer's disease (AD), but genetic drivers are unclear. METHODS In 2614 older adults (mean age ± SD: 73.7 ± 9.8 years; 26% cognitively impaired) from seven harmonized cohorts enriched for cognitive impairment, we quantified free‐water–corrected diffusion MRI ...
Anna S Lorenz, Aditi Sathe, Yisu Yang, Alaina Durant, Yiyang Wu, Michael E. Kim, Chenyu Gao, Nancy R. Newlin, Karthik Ramadass, Praitayini Kanakaraj, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Yuankai Huo, Logan Dumitrescu, Niranjana Shashikumar, Kimberly R. Pechman, Shannon L. Risacher, Lori L. Beason‐Held, Yang An, Konstantinos Arfanakis, Guray Erus, Christos Davatzikos, Mohamad Habes, Di Wang, Duygu Tosun, Arthur W. Toga, Paul M. Thompson, Elizabeth C. Mormino, Panpan Zhang, Kurt Schilling, Marilyn Albert, Walter Kukull, Sarah A. Biber, Bennett A. Landman, Sterling C. Johnson, Barbara Bendlin, Julie Schneider, David A. Bennett, Angela L. Jefferson, Susan M. Resnick, Andrew J. Saykin, Jennifer E. Below, Timothy J. Hohman, Derek B. Archer, Alzheimer's Disease Neuroimaging Initiative (ADNI), The BIOCARD Study Team (BIOCARD), The Alzheimer's Disease Sequencing Project (ADSP)   +47 more
wiley   +1 more source

Integrating GWAS and TWAS to elucidate the genetic architecture of maize leaf cuticular conductance [PDF]

, 2022
Meng Lin, Pengfei Qiao, Susanne Matschi, Miguel F. Vasquez, Guillaume P. Ramstein, Richard Bourgault, Marc Mohammadi, Michael J. Scanlon, Isabel Molina, Laurie G. Smith, Michael A. Gore   +10 more
openalex   +1 more source

Multi‐Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome‐Wide Association Meta‐Analyses, Machine Learning, and Drug Repurposing Study

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Background Schizophrenia is a psychiatric disorder characterized by a wide range of symptoms and a complex interplay between genetic and environmental factors. Despite advances in genomics, the genetic underpinnings of SC and its relationship with drug use remain poorly understood.
Ping Yan, Haili Wang, Ye Shu, Rui Xie, Ainiwaner Reyidan, Songnian Fu   +5 more
wiley   +1 more source

Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome‐Wide Cross‐Trait Analysis

Cancer Medicine, Volume 15, Issue 7, July 2026.
ABSTRACT Background Clinical and epidemiological evidence has suggested a potential association between kidney dysfunction and bladder cancer (BC). One hypothesis for this comorbidity is the presence of a common genetic etiology. However, little is known about the shared genetics and causality of this association.
Yifei Lin, Nanyan Xiang, Yong Yang, Shujun Huang, Shiqi Su, Tingting Fu, Yurui Luo, Zeng Wang, Rui Shi, Tao Zheng, Banghua Liao, Jin Huang   +11 more
wiley   +1 more source

Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI‐predicted functional consequences

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Genomic SEM of five ASCVD traits in > 3.8 million individuals identified 347 risk variants, including 19 novel loci. Integrating fine‐mapping and TWAS prioritized causal genes and revealed endothelial cell enrichment in vascular tissues. AI modelling shows the DCLRE1B mutation destabilizes the protein, impairing DNA repair and transcription.
Liwan Fu, Xiaodi Han, Qin Liu, Yuquan Wang, Yue‐Qing Hu   +4 more
wiley   +1 more source

Displacement as a Cultural Repertoire for Resilience in Chronic Crisis, in Burundi

Population, Space and Place, Volume 32, Issue 5, July 2026.
ABSTRACT Prior to a new outbreak of violence in Burundi in 2015, more than 10000 Burundians had already crossed borders in search of refuge. The anticipatory displacement signalled the need to rethink displacement as contextualised in the country's long history of conflict and decline.
Lidewyde H. Berckmoes
wiley   +1 more source

Expression- and splicing-based multi-tissue transcriptome-wide association studies identified multiple genes for breast cancer by estrogen-receptor status

Breast Cancer Research
Background Although several transcriptome-wide association studies (TWASs) have been performed to identify genes associated with overall breast cancer (BC) risk, only a few TWAS have explored the differences in estrogen receptor-positive (ER+) and ...
Julian C. McClellan, James L. Li, Guimin Gao, Dezheng Huo   +3 more
doaj   +1 more source

Subcutaneous Tranexamic Acid Achieves Comparable Serum Concentrations to Intramuscular Administration During Haemorrhagic Shock in a Swine Model

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Tranexamic acid is an antifibrinolytic agent reducing mortality when administered to trauma patients with haemorrhagic shock. This mortality reduction is time sensitive. Increased intramuscular dose administration has proven an effective alternative to intravenous administration in several studies and is used by some emergency ...
Trine Lynghaug, Ole Martin Fuskevåg, Benjamin Stage Storm, Erik Waage Nielsen, Bent Aksel Nilsen, Erik Sveberg Dietrichs, Håkon Kvåle Bakke   +6 more
wiley   +1 more source

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data

Aging Cell, Volume 25, Issue 7, July 2026.
This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from the UK Biobank. Our findings indicated that the two conditions may act as reciprocal risk factors, with multiple potential biomarkers mediating the muscle‐bone relationship and suggested possible shared signals between the ...
Siqi Xu, Simin Wen, Xizeng Zong, Jianwei Zhu, Qiuling Du, Yu Li, Kunyan Wang, Peihua Cao, Changhai Ding, Yan Zhang, Guangfeng Ruan   +10 more
wiley   +1 more source