Results 81 to 90 of about 8,098 (241)

Divergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis

Allergy, Volume 81, Issue 7, Page 2309-2324, July 2026.
ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí   +6 more
wiley   +1 more source

A New Framework to Empower Ecosystem Assessment Through the Integration of eDNA Inventories, Graph Theory and Niche Modelling

Ecology Letters, Volume 29, Issue 7, July 2026.
There is a lack of conceptual frameworks to validate the integration of eDNA and ecological network analysis into ecosystem monitoring. We propose a tool that combines eDNA inventories, graphlet‐based network analysis, ecological niche modelling and machine learning, and demonstrate that the associated topological metrics are effective for ecological ...
Benjamin Alric, Isabelle Domaizon, Christophe Laplace‐Treyture, Laurine Viollaz, Frédéric Rimet   +4 more
wiley   +1 more source

FABIO: TWAS fine-mapping to prioritize causal genes for binary traits.

PLoS Genetics
Transcriptome-wide association studies (TWAS) have emerged as a powerful tool for identifying gene-trait associations by integrating gene expression mapping studies with genome-wide association studies (GWAS). While most existing TWAS approaches focus on
Haihan Zhang, Kevin He, Zheng Li, Lam C Tsoi, Xiang Zhou   +4 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance Trichoderma atroviride 77B

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, the Netherlands, for the pesticide active substance Trichoderma atroviride 77B and the considerations as regards the inclusion of the substance in Annex IV of Regulation (EC) No 396/2005 ...
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Teresa Capilla Chavez, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Adriana Scattareggia Marchese, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning

Nature Communications
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expression imputation
Randy L. Parrish, Aron S. Buchman, Shinya Tasaki, Yanling Wang, Denis Avey, Jishu Xu, Philip L. De Jager, David A. Bennett, Michael P. Epstein, Jingjing Yang   +9 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance cymoxanil

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Lithuania, and the co‐rapporteur Member State, Finland, for the pesticide active substance cymoxanil are reported.
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +46 more
wiley   +1 more source

Uncovering causal gene-tissue pairs and variants through a multivariate TWAS controlling for infinitesimal effects

Nature Communications
Transcriptome-wide association studies (TWAS) are commonly used to prioritize causal genes underlying associations found in genome-wide association studies (GWAS) and have been extended to identify causal genes through multivariate TWAS methods. However,
Yihe Yang, Noah Lorincz-Comi, Xiaofeng Zhu   +2 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance Trichoderma harzianum T78

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, The Netherlands, for the pesticide active substance Trichoderma harzianum T78 and the considerations as regards the inclusion of the substance in Annex IV ...
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Adriana Scattareggia Marchese, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source

A genetic study to identify pathogenic mechanisms and drug targets for benign prostatic hyperplasia: a multi-omics Mendelian randomization study

Scientific Reports
Benign prostatic hyperplasia (BPH) as a common geriatric disease in urology, the incidence and prevalence are rapidly increasing with the aging society, prompting an urgent need for effective prevention and treatment of BPH.
Bohan Liu, Xinyi Wang, Zerui Yang, Zhaofa Yin, Cai Tang, Yushi He, Qi Ling, Zhongli Huang, Shijian Feng   +8 more
doaj   +1 more source

Genetic Correlation and Causal Inference Between Female Fat Distribution and Preeclampsia: An Integrative Genomic Study

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
We conducted integrative genomic analyses of large‐scale GWAS summary data to explore the shared polygenic architecture and causal link between female fat distribution (WHRadjBMI) and preeclampsia, identifying novel loci and critical vascular–immune pathways with implications for risk prediction.
Man Wang, Li Huang, Danfeng Zhang, Fengmei Yang, Lihua Wu, Bo Gao   +5 more
wiley   +1 more source