Results 101 to 110 of about 56,647 (174)

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS)
Keyu Jia, Jun Shen
doaj   +1 more source

The Crescent Student Newspaper, January 21, 1991

, 1990
Student newspaper of Pacific College (later George Fox University).
George Fox University Archives
core   +1 more source

Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes

Nature Communications
Transcriptome-wide association study (TWAS) is a popular approach to dissect the functional consequence of disease associated non-coding variants. Most existing TWAS use bulk tissues and may not have the resolution to reveal cell-type specific target ...
Lida Wang, Chachrit Khunsriraksakul, Havell Markus, Dieyi Chen, Fan Zhang, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang. J. Liu, Bibo Jiang   +9 more
doaj   +1 more source

Multi-ancestry transcriptome prediction with functionally informed variants in TOPMed MESA improves performance of transcriptome-wide association studies. [PDF]

Am J Hum Genet
Hu X, Araujo DS, Khunsriraksakul C, Wang L, Sun Q, Wen J, Zhou L, Ekunwe L, Lange LA, Lange EM, Montgomery SB, Reiner AP, Aguet F, Ardlie KG, Lappalainen T, Gignoux CR, Burchard EG, Taylor KD, Guo X, Rotter JI, Rich SS, Cornell E, Durda P, Tracy RP, Liu Y, Johnson WC, Papanicolaou GP, Perera MA, Cho MH, Liu DJ, Raffield LM, Li Y, TOPMed Multi-Omics Working Group, Wheeler HE, Im HK, Manichaikul A.   +35 more
europepmc   +1 more source

PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly. [PDF]

Curr Osteoporos Rep
Li S, Trajanoska K.
europepmc   +1 more source

Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma. [PDF]

Transl Vis Sci Technol
Pan Z, Liu K, Jiang B, Dong C.
europepmc   +1 more source

A Cross-Tissue Transcriptome Association Study Revealed Novel Susceptibility Genes for Chronic Obstructive Pulmonary Disease. [PDF]

Int J Chron Obstruct Pulmon Dis
Luan H, Wang T, Su X, Zhao J, Yuan Z, Ding S, Yang Y.   +6 more
europepmc   +1 more source

Identifying chemicals associated with irritable bowel syndrome by integrating a transcriptome-wide association study with chemical-gene-interaction analysis. [PDF]

PLoS One
Zhao X, Yang Y, Liu Z, Sun R, Suo A.
europepmc   +1 more source

TWAS atlas 2.0: an updated data resource for transcriptome-wide association studies. [PDF]

Nucleic Acids Res
Gao H, Bu C, Zheng S, Mai J, Wang J, Tang R, Fan Z, Zeng J, Li J, Xiao J.   +9 more
europepmc   +1 more source

A gene-specific variance-control approach corrects polygenicity-driven inflation observed in transcriptome-wide association studies. [PDF]

Am J Hum Genet
Liang Y, Nyasimi F, Im HK.
europepmc   +1 more source