Results 1 to 10 of about 5,749,254 (300)

Effect of mRNA Delivery Modality and Formulation on Cutaneous mRNA Distribution and Downstream eGFP Expression

Pharmaceutics, 2022
In vitro transcribed messenger ribonucleic acid (mRNA) constitutes an emerging therapeutic class with several clinical applications. This study presents a systematic comparison of different technologies—intradermal injection, microneedle injection, jet ...
Aditya R. Darade, Maria Lapteva, Thomas Hoffmann, Markus Mandler, Achim Schneeberger, Yogeshvar N. Kalia   +5 more
doaj   +2 more sources

Platelet Gene Expression as a Biomarker Risk Stratification Tool in Acute Myocardial Infarction: A Pilot Investigation

Clinical Medicine Insights: Blood Disorders, 2010
Platelets play a major role in the pathophysiology of acute myocardial infarction (AMI). Recent evidence reveals megakaryocyte-derived platelet pre-mRNA is spliced to mRNA and then translated into functional proteins in response to external stimulation ...
David C. Calverley, Ivan P. Casserly, Qamrul G. Choudhury, Tzu L. Phang, Bifeng Gao, John C. Messenger, Mark W. Geraci   +6 more
doaj   +2 more sources

Comprehensive Analysis and Co-Expression Network of mRNAs and lncRNAs in Pressure Overload-Induced Heart Failure

Frontiers in Genetics, 2019
Aim: Heart failure (HF) is the end stage of various cardiovascular diseases. However, the precise regulation of gene expression profiles and functional mechanisms of long non-coding RNAs (lncRNAs) in HF remain to be elucidated. The present study aimed to
Shuping Chen, Qiong Ma, Yanbo Xue, Jingwen Zhang, Guodong Yang, Tingzhong Wang, Tingzhong Wang, Tingzhong Wang, Aiqun Ma, Aiqun Ma, Aiqun Ma, Ling Bai   +11 more
doaj   +1 more source

Elucidating the Molecular Mechanism of Ischemic Stroke Using Integrated Analysis of miRNA, mRNA, and lncRNA Expression Profiles

Frontiers in Integrative Neuroscience, 2021
Objective: This study aimed to investigate the possible molecular mechanisms associated with ischemic stroke through the construction of a lncRNA-miRNA-mRNA network.
Yaxuan Sun, Jing Wang, Bin Han, Kun Meng, Yan Han, Yongxia Ding   +5 more
doaj   +1 more source

mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer

Molecular Cancer, 2007
Background Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and ...
Calin George A, Liu Chang-gong, Pichiorri Flavia, Spizzo Riccardo, Veronese Angelo, Gafà Roberta, Ferracin Manuela, Lanza Giovanni, Croce Carlo M, Negrini Massimo   +9 more
doaj   +1 more source

SCISSOR: a framework for identifying structural changes in RNA transcripts

Nature Communications, 2021
Many computational tools identify mRNA variations by analyzing the transformed RNA-seq data such as collapsed reads. Here, the authors report a computational method which uses shape changes in the RNA-seq coverage profile to discover changes in mRNA ...
Hyo Young Choi, Heejoon Jo, Xiaobei Zhao, Katherine A. Hoadley, Scott Newman, Jeremiah Holt, Michele C. Hayward, Michael I. Love, J. S. Marron, D. Neil Hayes   +9 more
doaj   +1 more source

Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets

Frontiers in Immunology, 2023
IntroductionMedulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, and Group 4.
Rui Ferreira Marques, Rui Ferreira Marques, Daniel Antunes Moreno, Luciane da Silva, Leticia Ferro Leal, Leticia Ferro Leal, Flávia Escremim de Paula, Iara Santana, Gustavo Teixeira, Fabiano Saggioro, Luciano Neder, Carlos Almeida Junior, Bruna Mançano, Rui Manuel Reis, Rui Manuel Reis, Rui Manuel Reis, Rui Manuel Reis   +16 more
doaj   +1 more source

Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet

Lipids in Health and Disease, 2018
Background Supplementation with Selenium (Se) has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however, the effects of Se supplementation, in combination with supplemental magnesium, on ...
Qian Zhang, Zhi-Yong Qian, Peng-Hui Zhou, Xiao-li Zhou, Da-Long Zhang, Ning He, Jing Zhang, Ying-Hua Liu, Qing Gu   +8 more
doaj   +1 more source

Expression profile analysis of 5-day-old neonatal piglets infected with porcine Deltacoronavirus

BMC Veterinary Research, 2019
Background Porcine deltacoronavirus (PDCoV) is a novel coronavirus that can cause diarrhea in nursing piglets. This study was aimed to investigate the roles of host differentially expressed genes on metabolic pathways in PDCoV infections.
Jiao L. Wu, Kai J. Mai, Di Li, Rui T. Wu, Zi X. Wu, Xiao Y. Tang, Qian N. Li, Yuan Sun, Tian Lan, Xiang B. Zhang, Jing Y. Ma   +10 more
doaj   +1 more source

Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal Development of Global Phase Transition Revealed in a Cancer Cell Line. [PDF]

PLoS ONE, 2015
BACKGROUND:The underlying mechanism of dynamic control of the genome-wide expression is a fundamental issue in bioscience. We addressed it in terms of phase transition by a systemic approach based on both density analysis and characteristics of temporal ...
Masa Tsuchiya, Alessandro Giuliani, Midori Hashimoto, Jekaterina Erenpreisa, Kenichi Yoshikawa   +4 more
doaj   +1 more source