Frontiers in Integrative Neuroscience, 2021 Objective: This study aimed to investigate the possible molecular mechanisms associated with ischemic stroke through the construction of a lncRNA-miRNA-mRNA network.
Yaxuan Sun +5 more
doaj +1 more source
mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
Molecular Cancer, 2007 Background Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and ...
Calin George A +9 more
doaj +1 more source
Altered expression of mRNA profiles in blood of early-onset schizophrenia [PDF]
Scientific Reports, 2016 AbstractTo identify gene expression abnormalities in schizophrenia (SZ), we generated whole-genome gene expression profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls. We detected 84 transcripts differentially expressed by diagnostic status, with 82 genes being upregulated and 2 ...
Yong Xu +10 more
openaire +2 more sources
The Role of Regulated mRNA Stability in Establishing Bicoid Morphogen Gradient in Drosophila Embryonic Development [PDF]
, 2011 The Bicoid morphogen is amongst the earliest triggers of differential spatial pattern of gene expression and subsequent cell fate determination in the embryonic development of Drosophila.
Niranjan Mahesan +5 more
core +3 more sources
Pharmaceutics, 2022 In vitro transcribed messenger ribonucleic acid (mRNA) constitutes an emerging therapeutic class with several clinical applications. This study presents a systematic comparison of different technologies—intradermal injection, microneedle injection, jet ...
Aditya R. Darade +5 more
doaj +1 more source
Individual mRNA expression profiles reveal the effects of specific microRNAs [PDF]
Genome Biology, 2008 Abstract Background MicroRNAs (miRNAs) are oligoribonucleotides with an important role in regulation of gene expression at the level of translation. Despite imperfect target complementarity, they can also significantly reduce mRNA levels.
Arora, A., Simpson, David
openaire +3 more sources
Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei [PDF]
, 2009 Background: Trypanosomes undergo extensive developmental changes during their complex life cycle. Crucial among these is the transition between slender and stumpy bloodstream forms and, thereafter, the differentiation from stumpy to tsetse-midgut ...
Ross Alan +22 more
core +1 more source
SCISSOR: a framework for identifying structural changes in RNA transcripts
Nature Communications, 2021 Many computational tools identify mRNA variations by analyzing the transformed RNA-seq data such as collapsed reads. Here, the authors report a computational method which uses shape changes in the RNA-seq coverage profile to discover changes in mRNA ...
Hyo Young Choi +9 more
doaj +1 more source
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]
, 2011 Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone +35 more
core +1 more source
Frontiers in Immunology, 2023 IntroductionMedulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, and Group 4.
Rui Ferreira Marques +16 more
doaj +1 more source