Pulsatile atheroprone shear stress affects the expression of transient receptor potential channels in human endothelial cells [PDF]
, 2012 The goal of the study was to assess whether pulsatile atheroprone shear stress modulates the expression of transient receptor potential (TRP) channels, TRPC3, TRPC6, TRPM7, and TRPV1 mRNA, in human umbilical vascular endothelial cells ...
Baumunk, Daniel +7 more
core +1 more source
P-cadherin counteracts myosin II-B function : implications in melanoma progression [PDF]
, 2010 BACKGROUND: Malignant transformation of melanocytes is frequently attended by a switch in cadherin expression profile as shown for E- and N-cadherin. For P-cadherin, downregulation in metastasizing melanoma has been demonstrated, and over-expression of P-
Jacobs, Koen +6 more
core +3 more sources
Prediction of photoperiodic regulators from quantitative gene circuit models [PDF]
, 2004 Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm.
A Waring +43 more
core +1 more source
Database of mRNA gene expression profiles of multiple human organs [PDF]
Genome Research, 2005 Genome-wide expression profiling of normal tissue may facilitate our understanding of the etiology of diseased organs and augment the development of new targeted therapeutics. Here, we have developed a high-density gene expression database of 18,927 unique genes for 158 normal human samples from 19 different organs of 30 different individuals using DNA
Chang Gue, Son +8 more
openaire +2 more sources
Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]
, 2015 Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee +6 more
core +2 more sources
Individual mRNA expression profiles reveal the effects of specific microRNAs [PDF]
Genome Biology, 2008 Abstract Background MicroRNAs (miRNAs) are oligoribonucleotides with an important role in regulation of gene expression at the level of translation. Despite imperfect target complementarity, they can also significantly reduce mRNA levels.
Arora, A., Simpson, David
openaire +3 more sources
Pharmaceutics, 2022 In vitro transcribed messenger ribonucleic acid (mRNA) constitutes an emerging therapeutic class with several clinical applications. This study presents a systematic comparison of different technologies—intradermal injection, microneedle injection, jet ...
Aditya R. Darade +5 more
doaj +1 more source
Stochastic Modeling of Expression Kinetics Identifies Messenger Half-Lives and Reveals Sequential Waves of Co-ordinated Transcription and Decay [PDF]
, 2012 The transcriptome in a cell is finely regulated by a large number of molecular mechanisms able to control the balance between mRNA production and degradation. Recent experimental findings have evidenced that fine and specific regulation of degradation is
Cacace, Filippo +4 more
core +3 more sources
Integrated analysis of microRNA and mRNA expression profiles in Preeclampsia
BMC Medical Genomics, 2023 Abstract Background Preeclampsia (PE), a pregnancy specific syndrome, is one kind of common gestational hypertension disease, which can cause maternal and perinatal mortality and morbidity. This study was conducted to identify key microRNAs (miRNAs), mRNAs and related signaling pathways in the pathogenesis of PE.
Zepeng Ping +4 more
openaire +3 more sources
SCISSOR: a framework for identifying structural changes in RNA transcripts
Nature Communications, 2021 Many computational tools identify mRNA variations by analyzing the transformed RNA-seq data such as collapsed reads. Here, the authors report a computational method which uses shape changes in the RNA-seq coverage profile to discover changes in mRNA ...
Hyo Young Choi +9 more
doaj +1 more source