Results 41 to 50 of about 664,318 (297)

Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets

Frontiers in Immunology, 2023
IntroductionMedulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, and Group 4.
Rui Ferreira Marques, Rui Ferreira Marques, Daniel Antunes Moreno, Luciane da Silva, Leticia Ferro Leal, Leticia Ferro Leal, Flávia Escremim de Paula, Iara Santana, Gustavo Teixeira, Fabiano Saggioro, Luciano Neder, Carlos Almeida Junior, Bruna Mançano, Rui Manuel Reis, Rui Manuel Reis, Rui Manuel Reis, Rui Manuel Reis   +16 more
doaj   +1 more source

Differences in leukocyte profile, gene expression, and metabolite status of dairy cows with or without sole ulcers [PDF]

, 2014
peer-reviewedSole ulcers are one of the most severe pathologies causing lameness in dairy cows and are associated with abnormal behavior and impaired production performance.
Aggarwal, Almeida, Almeida, Alsemgeest, Apple, Arya, Bernadette Earley, Bicalho, Bicalho, Buckham Sporer, Buckham-Sporer, Burton, Chao, Chen, Cooray, Davis, Derveaux, Fell, Fujishima, Galyean, Godson, Hart, Hellemans, Janeway, Jawor, Kansas, Keelin O’Driscoll, Knott, Kossaibati, Kulberg, Leeman, Lischer, Lischer, Matthew McCabe, McDowell, Moore, Murray, Nagata, Nocek, Opal, O’Driscoll, O’Driscoll, O’Driscoll, O’Loughlin, Preisler, Radostits, Rider, Shi, Smith, Tadich, Tarlton, Thoefner, Tomlinson, Watkins, Weber, Weber, Weissman, Whay, Whay, Wigmore   +59 more
core   +1 more source

Exploring MicroRNA Biomarkers for Parkinson’s Disease from mRNA Expression Profiles [PDF]

Cells, 2018
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease characterized by both motor and nonmotor features. The diagnose of PD is based on a review of patients’ signs and symptoms, and neurological and physical examinations. So far, no tests have been devised that can conclusively diagnose PD. In this study, we explore both microRNA
Y-h. Taguchi, Hsiuying Wang
openaire   +3 more sources

Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. [PDF]

, 2016
A comprehensive genomic and proteomic, computational, and physiological approach was employed to examine the (previously unexplored) role of microRNAs (miRNAs) as regulators of internal anal sphincter (IAS) smooth muscle contractile phenotype and basal ...
Addya, Sankar, Ettickan, Boopathi, Penn, Raymond B., Philllips, Benjamin, Rattan, Satish, Rigoutsos, Isidore, Singh, Jagmohan   +6 more
core   +3 more sources

LncRNA‐mRNA expression profiles and functional networks in osteoclast differentiation [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractHuman osteoclasts are differentiated from CD14+ monocytes and are responsible for bone resorption. Long non‐coding RNAs (lncRNAs) have been proved to be significantly involved in multiple biologic processes, especially in cell differentiation. However, the effect of lncRNAs in osteoclast differentiation is less appreciated.
Wenjie Liu, Zhaofeng Li, Zhaopeng Cai, Zhongyu Xie, Jinteng Li, Ming Li, Shuizhong Cen, Su'an Tang, Guan Zheng, Guiwen Ye, Hongjun Su, Shan Wang, Peng Wang, Huiyong Shen, Yanfeng Wu   +14 more
openaire   +2 more sources

ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer. [PDF]

, 2018
The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma.
Bafna, Vineet, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Nguyen, Nam-Phuong D   +4 more
core   +1 more source

Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet

Lipids in Health and Disease, 2018
Background Supplementation with Selenium (Se) has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however, the effects of Se supplementation, in combination with supplemental magnesium, on ...
Qian Zhang, Zhi-Yong Qian, Peng-Hui Zhou, Xiao-li Zhou, Da-Long Zhang, Ning He, Jing Zhang, Ying-Hua Liu, Qing Gu   +8 more
doaj   +1 more source

DACH1 suppresses breast cancer as a negative regulator of CD44. [PDF]

, 2017
Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack ...
Kuang, Dong, Pestell, Richard, Wu, Kongming, Xiong, Jing, Xu, Hanxiao, Yu, Shengnan, Yuan, Xun   +6 more
core   +2 more sources

Expression profiling of Drosophila mitochondrial genes via deep mRNA sequencing [PDF]

Nucleic Acids Research, 2009
Mitochondria play an essential role in several cellular processes. Nevertheless, very little is known about patterns of gene expression of genes encoded by the mitochondrial DNA (mtDNA). In this study, we used next-generation sequencing (NGS) for transcription profiling of genes encoded in the mitochondrial genome of Drosophila melanogaster and D ...
Torres, Tatiana Teixeira, Dolezal, Marlies, Schlötterer, Christian, Ottenwälder, Birgit   +3 more
openaire   +2 more sources

Expression profile analysis of 5-day-old neonatal piglets infected with porcine Deltacoronavirus

BMC Veterinary Research, 2019
Background Porcine deltacoronavirus (PDCoV) is a novel coronavirus that can cause diarrhea in nursing piglets. This study was aimed to investigate the roles of host differentially expressed genes on metabolic pathways in PDCoV infections.
Jiao L. Wu, Kai J. Mai, Di Li, Rui T. Wu, Zi X. Wu, Xiao Y. Tang, Qian N. Li, Yuan Sun, Tian Lan, Xiang B. Zhang, Jing Y. Ma   +10 more
doaj   +1 more source