Results 41 to 50 of about 5,429,710 (293)

Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer’s Disease [PDF]

Medical Science Monitor, 2017
BACKGROUND Our study aimed to identify key differentially expressed genes (DEGs) and miRNAs (DEmiRNAs) which can serve as potential biomarkers for diagnosis and therapy of Alzheimer's disease (AD). MATERIAL AND METHODS We performed miRNA and mRNA integrated analysis (MMIA) to identify DEGs and DEmiRNAs of AD.
Chang, Wan-Sheng, Wang, Yong-Hong, Zhu, Xiao-Tun, Wu, Chuan-Jie   +3 more
openaire   +2 more sources

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner, Metzner, Julia, Nicole Schnur, Manuel Grez, Grez, Manuel, Katryniok, Careen, Careen Katryniok, Bernd L. Sorg, Dieter Steinhilber, Laura Pufahl, Sorg, Bernd Lothar, Pufahl, Laura, Schnur, Nicole, Steinhilber, Dieter   +13 more
core   +1 more source

Transcriptional Profiling of Circadian Patterns of mRNA Expression in the Chick Retina [PDF]

Journal of Biological Chemistry, 2004
Previous transcriptome analyses have identified candidate molecular components of the avian pineal clock, and herein we employ high density cDNA microarrays of pineal gland transcripts to determine oscillating transcripts in the chick retina under daily and constant darkness conditions.
Michael J, Bailey, Phillip D, Beremand, Rick, Hammer, Elizabeth, Reidel, Terry L, Thomas, Vincent M, Cassone   +5 more
openaire   +2 more sources

mRNA expression profiling of mitochondrial subunits in subjects with Parkinson’s disease

Archives of Medical Science, 2021
IntroductionParkinson's disease (PD) is a common adult-onset neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. Mitochondria are known to play a key role in cell respiratory function and bioenergetics.
Salemi, Michele, Cosentino, Filomena, Lanza, Giuseppe, Cantone, Mariagiovanna, Salluzzo, Maria Grazia, Giurato, Giorgio, Borgione, Eugenia, Marchese, Giovanna, Santa Paola, Sandro, Lanuzza, Bartolo, Romano, Corrado, Ferri, Raffaele   +11 more
openaire   +4 more sources

Quantification of pre-mRNA escape rate and synergy in splicing [PDF]

, 2014
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila, Bonde, M. (M) M. (M), Becskei, A. (A), Baudrimont, A. (A), Séraphin, B. (Bertrand), Mi Bonde, Marie, Voegeli, Sylvia, Bonde, Marie Mi, Baudrimont, Antoine, Voegeli, S. (S), Séraphin, Bertrand, Voegeli, S, Baudrimont, A, Becskei, A   +13 more
core   +1 more source

Database of mRNA gene expression profiles of multiple human organs [PDF]

Genome Research, 2005
Genome-wide expression profiling of normal tissue may facilitate our understanding of the etiology of diseased organs and augment the development of new targeted therapeutics. Here, we have developed a high-density gene expression database of 18,927 unique genes for 158 normal human samples from 19 different organs of 30 different individuals using DNA
Chang Gue, Son, Sven, Bilke, Sean, Davis, Braden T, Greer, Jun S, Wei, Craig C, Whiteford, Qing-Rong, Chen, Nicola, Cenacchi, Javed, Khan   +8 more
openaire   +2 more sources

Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet

Lipids in Health and Disease, 2018
Background Supplementation with Selenium (Se) has been shown to lower blood cholesterol and increase tissue concentrations of the antioxidant glutathione (GSH); however, the effects of Se supplementation, in combination with supplemental magnesium, on ...
Qian Zhang, Zhi-Yong Qian, Peng-Hui Zhou, Xiao-li Zhou, Da-Long Zhang, Ning He, Jing Zhang, Ying-Hua Liu, Qing Gu   +8 more
doaj   +1 more source

Emergent Self-Organized Criticality in Gene Expression Dynamics: Temporal Development of Global Phase Transition Revealed in a Cancer Cell Line. [PDF]

PLoS ONE, 2015
BACKGROUND:The underlying mechanism of dynamic control of the genome-wide expression is a fundamental issue in bioscience. We addressed it in terms of phase transition by a systemic approach based on both density analysis and characteristics of temporal ...
Masa Tsuchiya, Alessandro Giuliani, Midori Hashimoto, Jekaterina Erenpreisa, Kenichi Yoshikawa   +4 more
doaj   +1 more source

Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

Molecular Therapy: Nucleic Acids, 2023
Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases ...
Justin S. Antony, Pascale Birrer, Claudia Bohnert, Sina Zimmerli, Petra Hillmann, Hervé Schaffhauser, Christine Hoeflich, Andreas Hoeflich, Ramzi Khairallah, Andreas T. Satoh, Isabelle Kappeler, Isabel Ferreira, Klaas P. Zuideveld, Friedrich Metzger   +13 more
doaj   +1 more source

Using mRNA expression profiling to determine anticancer drug efficacy [PDF]

Cytometry, 2001
AbstractPharmacogenomics is a fast‐growing field of investigations that aims to further elucidate the inherited nature of interindividual differences in drug disposition and effects, with the ultimate goal of providing a stronger scientific basis for selecting the optimal drug therapy.
Gerrit, Los, Fei, Yang, Goli, Samimi, Gerald, Manorek, Ivelina M, Guerorguieva, Stephan, Howell, Nielka, van Erp, James K, Breaux   +7 more
openaire   +2 more sources