Results 41 to 50 of about 5,749,254 (300)

Quantification of pre-mRNA escape rate and synergy in splicing [PDF]

, 2014
Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila, Bonde, M. (M) M. (M), Becskei, A. (A), Baudrimont, A. (A), Séraphin, B. (Bertrand), Mi Bonde, Marie, Voegeli, Sylvia, Bonde, Marie Mi, Baudrimont, Antoine, Voegeli, S. (S), Séraphin, Bertrand, Voegeli, S, Baudrimont, A, Becskei, A, Voegeli S, Séraphin B, Becskei A, Baudrimont A, Bonde MM   +18 more
core   +1 more source

Baseline profile of SjD patients treated with hydroxychloroquine, stratified by minor salivary gland LAMP3 mRNA expression.

, 2023
Baseline profile of SjD patients treated with hydroxychloroquine, stratified by minor salivary gland LAMP3 mRNA expression.
Sandra A. Afione (14670813), Tatsuya Atsumi (186298), John A. Chiorini (11168839), Hiroyuki Nakamura (200082), Ana Carolina F. Motta (14670816), Youngmi Ji (671941), Changyu Zheng (315875), Tsutomu Tanaka (3206490), Blake M. Warner (11168818), Fabiola Reis Oliveira (11385424), Eduardo M. Rocha (5738948), Masayuki Noguchi (506967)   +11 more
core   +1 more source

Individual mRNA expression profiles reveal the effects of specific microRNAs [PDF]

Genome Biology, 2008
Abstract Background MicroRNAs (miRNAs) are oligoribonucleotides with an important role in regulation of gene expression at the level of translation. Despite imperfect target complementarity, they can also significantly reduce mRNA levels.
Arora, A., Simpson, David
openaire   +3 more sources

Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]

, 2012
The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner, Metzner, Julia, Nicole Schnur, Manuel Grez, Grez, Manuel, Katryniok, Careen, Careen Katryniok, Bernd L. Sorg, Dieter Steinhilber, Laura Pufahl, Sorg, Bernd Lothar, Pufahl, Laura, Schnur, Nicole, Steinhilber, Dieter   +13 more
core   +1 more source

Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer’s Disease [PDF]

Medical Science Monitor, 2017
BACKGROUND Our study aimed to identify key differentially expressed genes (DEGs) and miRNAs (DEmiRNAs) which can serve as potential biomarkers for diagnosis and therapy of Alzheimer's disease (AD). MATERIAL AND METHODS We performed miRNA and mRNA integrated analysis (MMIA) to identify DEGs and DEmiRNAs of AD.
Chang, Wan-Sheng, Wang, Yong-Hong, Zhu, Xiao-Tun, Wu, Chuan-Jie   +3 more
openaire   +2 more sources

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source

Transcriptional Profiling of Circadian Patterns of mRNA Expression in the Chick Retina [PDF]

Journal of Biological Chemistry, 2004
Previous transcriptome analyses have identified candidate molecular components of the avian pineal clock, and herein we employ high density cDNA microarrays of pineal gland transcripts to determine oscillating transcripts in the chick retina under daily and constant darkness conditions.
Michael J, Bailey, Phillip D, Beremand, Rick, Hammer, Elizabeth, Reidel, Terry L, Thomas, Vincent M, Cassone   +5 more
openaire   +2 more sources

mRNA expression profiling of mitochondrial subunits in subjects with Parkinson’s disease

Archives of Medical Science, 2021
IntroductionParkinson's disease (PD) is a common adult-onset neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. Mitochondria are known to play a key role in cell respiratory function and bioenergetics.
Salemi, Michele, Cosentino, Filomena, Lanza, Giuseppe, Cantone, Mariagiovanna, Salluzzo, Maria Grazia, Giurato, Giorgio, Borgione, Eugenia, Marchese, Giovanna, Santa Paola, Sandro, Lanuzza, Bartolo, Romano, Corrado, Ferri, Raffaele   +11 more
openaire   +4 more sources

Database of mRNA gene expression profiles of multiple human organs [PDF]

Genome Research, 2005
Genome-wide expression profiling of normal tissue may facilitate our understanding of the etiology of diseased organs and augment the development of new targeted therapeutics. Here, we have developed a high-density gene expression database of 18,927 unique genes for 158 normal human samples from 19 different organs of 30 different individuals using DNA
Chang Gue, Son, Sven, Bilke, Sean, Davis, Braden T, Greer, Jun S, Wei, Craig C, Whiteford, Qing-Rong, Chen, Nicola, Cenacchi, Javed, Khan   +8 more
openaire   +2 more sources

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]

, 2012
In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak, Geißler, S., Mamo, S., Horsch, Marion, Horsch, M., Andras Dinnyes, Geissler, Sandra, Mamo, Solomon, Marion Horsch, Kobolak, J., Beckers, Johannes, Solomon Mamo, Kobolak, Julianna, Dinnyes, Andras, Beckers, J., Johannes Beckers, Sandra Geißler, Dinnyes, A.   +17 more
core   +1 more source