Results 61 to 70 of about 664,318 (297)
The International Journal of Biological Markers, 2010 Aims To analyze the promoter methylation profile and mRNA expression of the p14 ARF gene in oral squamous cell carcinoma (OSCC). Methods Promoter methylation of the p14 ARF gene was investigated by methylation-specific polymerase chain reaction in ...
Dor Mohammad Kordi-Tamandani +5 more
doaj +1 more source
Protein and RNA quantification of multiple genes in single cells
BioTechniques, 2019 Single-cell analysis overcomes the problems of cellular heterogeneity by revealing the individual differences between cells in tissue. The current tools used to profile gene expression at the single-cell level are arduous and often require specialized ...
Ibrahim Kays, Brian Edwin Chen
doaj +1 more source
Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit +73 more
core +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Modeling miRNA-mRNA interactions that cause phenotypic abnormality in breast cancer patients.
PLoS ONE, 2017 BackgroundThe dysregulation of microRNAs (miRNAs) alters expression level of pro-oncogenic or tumor suppressive mRNAs in breast cancer, and in the long run, causes multiple biological abnormalities.
Sanghoon Lee, Xia Jiang
doaj +1 more source
Journal of Integrative Agriculture, 2020 Previous studies on mammals showed that peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) played a prominent role in regulating muscle fiber type transition and composition.
Yan-ju SHAN +7 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Mathematical models of morphogen gradients and their effects on gene expression [PDF]
, 2012 not ...
Baker, R. E., Shvartsman, S Y
core +2 more sources
CircRNA expression profile and circRNA-miRNA-mRNA crosstalk in allergic rhinitis [PDF]
World Allergy Organization Journal, 2020 Circular RNAs (circRNAs) are involved in inflammation; however, their role in allergic rhinitis (AR) remains unclear. In this study, we analyzed circRNA expression and identified a circRNA-miRNA-mRNA network through which circRNAs regulate AR pathogenesis.We analyzed circRNA, miRNA, and mRNA expression profiles in the nasal mucosa by high-throughput ...
Chang-Yu Qiu +7 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source