Results 61 to 70 of about 5,749,254 (300)

Integrated analysis of microRNA and mRNA expression profiles in HBx-expressing hepatic cells

World Journal of Gastroenterology, 2017
To identify the miRNA-mRNA regulatory network in hepatitis B virus X (HBx)-expressing hepatic cells.A stable HBx-expressing human liver cell line L02 was established. The mRNA and miRNA expression profiles of L02/HBx and L02/pcDNA liver cells were identified by RNA-sequencing analysis. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis
Chen, Ruo-Chan, Wang, Juan, Kuang, Xu-Yuan, Peng, Fang, Fu, Yong-Ming, Huang, Yan, Li, Ning, Fan, Xue-Gong   +7 more
openaire   +2 more sources

Identification of pterygium-related mRNA expression profiling by microarray analysis [PDF]

Eye, 2017
PurposePterygium is a common degenerative and proliferative disease of the ocular surface. In some severe cases, pterygium may lead to irregular corneal astigmatism and corneal stromal scarring with visual impairment. The proliferative capacities of pterygial cells make them appear similar to tumorigenesis.
J, Liu, X, Ding, L, Yuan, X, Zhang
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes [PDF]

, 1992
Glucose uptake by rabbit intestine has been shown to be confined to the upper two-thirds of jejunal villi. Inhibition by phloridzin shows most of this transport to take place through the Na(+)-glucose linked transporter (SGLT1).
Turvey, A, Freeman, T C, MW Smith, Smith, M W, A Turvey, TC Freeman   +5 more
core   +1 more source

Protein and RNA quantification of multiple genes in single cells

BioTechniques, 2019
Single-cell analysis overcomes the problems of cellular heterogeneity by revealing the individual differences between cells in tissue. The current tools used to profile gene expression at the single-cell level are arduous and often require specialized ...
Ibrahim Kays, Brian Edwin Chen
doaj   +1 more source

MicroRNA–mRNA expression profiles associated with medulloblastoma subgroup 4

Cancer Management and Research, 2018
Medulloblastoma (MB), the most common malignant brain tumor in children, is divided into four tumor subgroups: wingless-type (WNT), sonic hedgehog (SHH), Group 3, and Group 4. Ideally, clinical practice and treatment design should be subgroup specific. While WNT and SHH subgroups have well-defined biomarkers, distinguishing Group 3 from Group 4 is not ...
Sivan Gershanov, Helen Toledano, Shalom Michowiz, Orit Barinfeld, Albert Pinhasov, Nitza Goldenberg-Cohen, Mali Salmon-Divon   +6 more
openaire   +5 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analysis of Methylation Patterns and Expression Profiles of P14 Gene in Patients with Oral Squamous Cell Carcinoma

The International Journal of Biological Markers, 2010
Aims To analyze the promoter methylation profile and mRNA expression of the p14 ARF gene in oral squamous cell carcinoma (OSCC). Methods Promoter methylation of the p14 ARF gene was investigated by methylation-specific polymerase chain reaction in ...
Dor Mohammad Kordi-Tamandani, Abdolkarim Moazeni-Roodi, Mohammad Ayoub Rigi Ladez, Mohammad Hashemi, Elnaz Birjandian, Adam Torkamanzehi   +5 more
doaj   +1 more source

Tissue-specific mRNA expression profiling in grape berry tissues [PDF]

BMC Genomics, 2007
AbstractBackgroundBerries of grape (Vitis vinifera) contain three major tissue types (skin, pulp and seed) all of which contribute to the aroma, color, and flavor characters of wine. The pericarp, which is composed of the exocarp (skin) and mesocarp (pulp), not only functions to protect and feed the developing seed, but also to assist in the dispersal ...
Grimplet, Jerome, Deluc, Laurent G., Tillett, Richard L., Wheatley, Matthew D., Schlauch, Karen A., Cramer, Grant R., Cushman, John C.   +6 more
openaire   +4 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source