Results 61 to 70 of about 5,429,710 (293)
Integrated analysis of microRNA and mRNA expression profiles in HBx-expressing hepatic cells
World Journal of Gastroenterology, 2017 To identify the miRNA-mRNA regulatory network in hepatitis B virus X (HBx)-expressing hepatic cells.A stable HBx-expressing human liver cell line L02 was established. The mRNA and miRNA expression profiles of L02/HBx and L02/pcDNA liver cells were identified by RNA-sequencing analysis. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis
Chen, Ruo-Chan +7 more
openaire +2 more sources
Identification of pterygium-related mRNA expression profiling by microarray analysis [PDF]
Eye, 2017 PurposePterygium is a common degenerative and proliferative disease of the ocular surface. In some severe cases, pterygium may lead to irregular corneal astigmatism and corneal stromal scarring with visual impairment. The proliferative capacities of pterygial cells make them appear similar to tumorigenesis.
J, Liu, X, Ding, L, Yuan, X, Zhang
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Protein and RNA quantification of multiple genes in single cells
BioTechniques, 2019 Single-cell analysis overcomes the problems of cellular heterogeneity by revealing the individual differences between cells in tissue. The current tools used to profile gene expression at the single-cell level are arduous and often require specialized ...
Ibrahim Kays, Brian Edwin Chen
doaj +1 more source
MicroRNA–mRNA expression profiles associated with medulloblastoma subgroup 4
Cancer Management and Research, 2018 Medulloblastoma (MB), the most common malignant brain tumor in children, is divided into four tumor subgroups: wingless-type (WNT), sonic hedgehog (SHH), Group 3, and Group 4. Ideally, clinical practice and treatment design should be subgroup specific. While WNT and SHH subgroups have well-defined biomarkers, distinguishing Group 3 from Group 4 is not ...
Sivan Gershanov +6 more
openaire +5 more sources
Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes [PDF]
, 1992 Glucose uptake by rabbit intestine has been shown to be confined to the upper two-thirds of jejunal villi. Inhibition by phloridzin shows most of this transport to take place through the Na(+)-glucose linked transporter (SGLT1).
Turvey, A +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Integrative Agriculture, 2020 Previous studies on mammals showed that peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) played a prominent role in regulating muscle fiber type transition and composition.
Yan-ju SHAN +7 more
doaj +1 more source
Tissue-specific mRNA expression profiling in grape berry tissues [PDF]
BMC Genomics, 2007 AbstractBackgroundBerries of grape (Vitis vinifera) contain three major tissue types (skin, pulp and seed) all of which contribute to the aroma, color, and flavor characters of wine. The pericarp, which is composed of the exocarp (skin) and mesocarp (pulp), not only functions to protect and feed the developing seed, but also to assist in the dispersal ...
Grimplet, Jerome +6 more
openaire +4 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source