Results 81 to 90 of about 5,429,710 (293)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Identification of key modules and hub genes involved in regulating the feather follicle development of Wannan chickens using WGCNA

Poultry Science
: Carcass appearance is important economic trait, which affects customers in making purchase decisions. Both density and diameter of feather follicles are two important indicators of carcass appearance.
Jiangxian Wang, Chaohui Xing, Hao Wang, Hong Zhang, Wei Wei, Jinmei Xu, Yanan Liu, Xing Guo, Runshen Jiang   +8 more
doaj   +1 more source

HnRNP Q Has a Suppressive Role in the Translation of Mouse Cryptochrome1. [PDF]

PLoS ONE, 2016
Precise regulation of gene expression is especially important for circadian timekeeping which is maintained by the proper oscillation of the mRNA and protein of clock genes and clock-controlled genes. As a main component of the core negative arm feedback
Ilgye Lim, Youngseob Jung, Do-Yeon Kim, Kyong-Tai Kim   +3 more
doaj   +1 more source

Expression profile of mRNAs from human pancreatic islet tumors [PDF]

Journal of Molecular Endocrinology, 2003
Abstract In order to understand the tIssue specificity of the endocrine pancreas, it is important to clarify the expression profile of mRNAs in various states of the tIssue. A total of approximately 9000 non-redundant expressed genes from human pancreatic islets and insulinoma have so far been determined as expressed sequence tags ...
L, Jin, H, Wang, T, Narita, R, Kikuno, O, Ohara, N, Shihara, T, Nishigori, Y, Horikawa, J, Takeda   +8 more
openaire   +2 more sources

Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice [PDF]

, 2010
The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions.
Filipenko Maxim L., Natalia N Kudryavtseva, Maxim L Filipenko, Ul'yana A. Boyarskikh, Natalia P Bondar, Ul'yana A. Boyarskikh, Natalia N. Kudryavtseva, Bondar Natalia P., Ul'yana A Boyarskikh, Kudryavtseva Natalia N., Boyarskikh Ul'yana A., Maxim L. Filipenko, Natalia P. Bondar   +12 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling.

PLoS ONE, 2016
Uptake of Ca2+ into the mitochondrial matrix controls cellular metabolism and survival-death pathways. Several genes are implicated in controlling mitochondrial Ca2+ uptake (mitochondrial calcium regulatory genes, MCRGs), however, less is known about the
Nóra M Márkus, Philip Hasel, Jing Qiu, Karen F S Bell, Samuel Heron, Peter C Kind, Owen Dando, T Ian Simpson, Giles E Hardingham   +8 more
doaj   +1 more source

Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. [PDF]

PLoS ONE, 2016
BACKGROUND:Experiments in isolated perfused heart have shown that heart rate is lower and sinoatrial node (SAN) action potential duration is longer in streptozotocin (STZ)-induced diabetic rat compared to controls.
Zannatul Ferdous, Muhammad Anwar Qureshi, Petrilla Jayaprakash, Khatija Parekh, Annie John, Murat Oz, Haider Raza, Halina Dobrzynski, Thomas Edward Adrian, Frank Christopher Howarth   +9 more
doaj   +1 more source

Biologically relevant effects of mRNA amplification on gene expression profiles [PDF]

BMC Bioinformatics, 2006
Abstract Background Gene expression microarray technology permits the analysis of global gene expression profiles. The amount of sample needed limits the use of small excision biopsies and/or needle biopsies from human or animal tissues.
van Haaften, Rachel I. M., Schroen, Blanche, Janssen, Ben J. A., van Erk, Arie, Debets, Jacques J. M., Smeets, Hubert J. M., Smits, Jos F. M., van den Wijngaard, Arthur, Pinto, Yigal M., Evelo, Chris T. A.   +9 more
openaire   +5 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source