Results 101 to 110 of about 5,749,254 (300)

Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes [PDF]

International Journal of Molecular Sciences, 2016
Wilms tumor (WT) is the most common childhood renal cancer. Recent findings of mutations in microRNA (miRNA) processing proteins suggest a pivotal role of miRNAs in WT genesis. We performed miRNA expression profiling of 36 WTs of different subtypes and four normal kidney tissues using microarrays. Additionally, we determined the gene expression profile
Nicole Ludwig, Tamara Werner, Christina Backes, Patrick Trampert, Manfred Gessler, Andreas Keller, Hans-Peter Lenhof, Norbert Graf, Eckart Meese   +8 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA

, 2008
Regulation of the synthesis, function and degradation of HDM2 (Mdm2 in mouse) plays a key role in controlling the abundance and activity of the transcription factor p53, with consequent implications for the proliferation and survival of normal and cancer
A Phillips, J P Blaydes, Phillips, A., Blaydes, J.P.   +3 more
core   +1 more source

Quantification of global transcription patterns in prokaryotes using spotted microarrays [PDF]

, 2007
We describe an analysis, applicable to any spotted microarray dataset produced using genomic DNA as a reference, that quantifies prokaryotic levels of mRNA on a genome-wide scale.
Sidders, B, Cox, Robert A, Hinds, Jason, Movahedzadeh, Farahnaz, Jason Hinds (41307), Cox, R A, Sharon L Kendall (16050482), Ten Bokum, A M C, Ben Sidders (35030), Movahedzadeh, F., Lorenz Wernisch (9596), Waddell, S J, Frita, R, Sidders, Ben, Farahnaz Movahedzadeh (41309), Waddell, SJ, Frita, Rosangela, Simon Waddell (4462816), Movahedzadeh, F, Stoker, N G, Withers, M., Kendall, S L, ten Bokum, A.M.C., Robert A Cox (16050485), Hinds, J, Waddell, S.J., Ten Bokum, AM, Bacon, J, Golby, P., Withers, Mike, Hinds, J., Wernisch, L, Paul Golby (41308), Annemieke M C Ten Bokum (16050488), Kendall, Sharon L, Stoker, NG, Cox, RA, Rosangela Frita (35031), Ten Bokum, Annemieke MC, Bacon, J., Kendall, SL, Stoker, N.G., Ten Bokum, AMC, Neil G Stoker (16048313), Mike Withers (35026), Sidders, B., Golby, P, Bacon, Joanna, Golby, Paul, Waddell, Simon J, Wernisch, Lorenz, Stoker, Neil G, Frita, R., Withers, M, Kendall, S.L., Cox, R.A., Joanna Bacon (41305), Ben Sidders, Lorenz Wernisch, Robert A Cox, Rosangela Frita, Farahnaz Movahedzadeh, Simon J Waddell, Paul Golby, Mike Withers, Jason Hinds, Annemieke MC ten Bokum, Sharon L Kendall, Joanna Bacon, Neil G Stoker   +69 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina, Edina Zelei, M Victoria Milanés, Polyák, Ágnes, Zelei, Edina, Agnes Polyák, Krisztina J Kovács, Kovács, Krisztina J., Cristina Núnez, Milanes, Victoria M., Pintér-Kübler, Bernadett, Ferenczi, Szilamér, Bernadett Pintér-Kübler, Szilamér Ferenczi   +13 more
core   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice [PDF]

, 2010
The study aimed to analyze the mRNA levels of Snca and Bdnf genes in the ventral tegmental area (VTA) and raphe nuclei of the midbrain in male mice that had each won or defeated 20 encounters in daily agonistic interactions.
Filipenko Maxim L., Natalia N Kudryavtseva, Maxim L Filipenko, Ul'yana A. Boyarskikh, Natalia P Bondar, Ul'yana A. Boyarskikh, Natalia N. Kudryavtseva, Bondar Natalia P., Ul'yana A Boyarskikh, Kudryavtseva Natalia N., Boyarskikh Ul'yana A., Maxim L. Filipenko, Natalia P. Bondar   +12 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Circadian expression of tryptophan hydroxylase mRNA in the chicken retina

, 1998
Many aspects of retinal physiology are controlled by a circadian clock located within the eye. This clock controls the rhythmic synthesis of melatonin, which results in elevated levels during the night and low levels during the day.
Cassone, V.M., Iuvone, P.M., Chong, Nelson W., Bernard, M., Klein, D.C.   +4 more
core   +1 more source