Results 111 to 120 of about 5,429,710 (293)

Analysis of cis-acting expression determinants of the tobacco psbA 5’UTR in vivo [PDF]

, 2002
Chloroplast gene expression is predominantly regulated at the posttranscriptional levels of mRNA stability and translation efficiency. The expression of psbA, an important photosynthesis-related chloroplast gene, has been revealed to be regulated via its
Zou, Zhurong
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer [PDF]

, 2013
Introduction: Recent data suggest that benefit from trastuzumab and chemotherapy might be related to expression of HER2 and estrogen receptor (ESR1). Therefore, we investigated HER2 and ESR1 mRNA levels in core biopsies of HER2-positive breast carcinomas
Jens Huober, Reinisch, Mattea, Sibylle Loibl, Silvia Darb-Esfahani, Michael Untch, Hans Tesch, Martin-Leo Hansmann, Jan C Brase, Knut Engels, Judith Prinzler, Keyur Mehta, Minckwitz, Gunter von, Brase, Jan C., Kronenwett, Ralf, Hansmann, Martin-Leo, Huober, Jens, Engels, Knut, Solbach, Christine, Tesch, Hans, Carsten Denkert, Denkert, Carsten, Gunter von Minckwitz, Bruno V Sinn, Loibl, Sibylle, Mattea Reinisch, Peter A Fasching, Sinn, Bruno V., Ralf Kronenwett, Christine Solbach, Prinzler, Judith, Mehta, Keyur, Fasching, Peter Andreas, Untch, Michael, Denkert, Carsten Michael, Darb-Esfahani, Silvia   +34 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Expression Profile of Hyaluronidase mRNA Transcripts in the Kidney and in Renal Cells

Kidney and Blood Pressure Research, 1998
The accumulation of hyaluronan (HA) in the renal cortex is a characteristic feature of inflammatory renal diseases. Fragments of HA derived from high molecular weight precursors are known to display inflammatory effects in vitro and could, therefore, participate in immune renal injury.
Sun L, Feusi E, Sibalic A, Beck-Schimmer B, Wüthrich RP   +4 more
openaire   +3 more sources

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Söderkvist, Peter, Gidlöf, Anders, Uhl, Eberhard, Carlsson, Maria, Öst, Martin, Sirsjö, Allan   +5 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

siqRNA-seq is a spike-in-independent technique for quantitative mapping of mRNA landscape

BMC Genomics
Background RNA sequencing (RNA-seq) is widely used for gene expression profiling and quantification. Quantitative RNA sequencing usually requires cell counting and spike-in, which is not always applicable to many samples.
Zhenzhen Wang, Kehan Tao, Jiaojiao Ji, Changbin Sun, Wei Xu   +4 more
doaj   +1 more source

Quantification of global transcription patterns in prokaryotes using spotted microarrays [PDF]

, 2007
We describe an analysis, applicable to any spotted microarray dataset produced using genomic DNA as a reference, that quantifies prokaryotic levels of mRNA on a genome-wide scale.
Sidders, B, Cox, Robert A, Hinds, Jason, Movahedzadeh, Farahnaz, St George's, LSHTM, Jason Hinds (41307), Cox, R A, Sharon L Kendall (16050482), Ten Bokum, A M C, Ben Sidders (35030), Movahedzadeh, F., Lorenz Wernisch (9596), Waddell, S J, Frita, R, Sidders, Ben, Farahnaz Movahedzadeh (41309), Waddell, SJ, Frita, Rosangela, Simon Waddell (4462816), Movahedzadeh, F, Stoker, N G, Withers, M., Kendall, S L, ten Bokum, A.M.C., Robert A Cox (16050485), Hinds, J, Waddell, S.J., Ten Bokum, AM, HPA, Bacon, J, Golby, P., National Inst For Medical Research, Illinois, USA, Withers, Mike, Hinds, J., Wernisch, L, VLA, Paul Golby (41308), Annemieke M C Ten Bokum (16050488), Kendall, Sharon L, Stoker, NG, Cox, RA, Rosangela Frita (35031), Ten Bokum, Annemieke MC, Bacon, J., Kendall, SL, Stoker, N.G., Ten Bokum, AMC, Neil G Stoker (16048313), Mike Withers (35026), Sidders, B., Golby, P, Bacon, Joanna, Golby, Paul, Birkbeck College, Waddell, Simon J, Wernisch, Lorenz, Stoker, Neil G, Frita, R., Withers, M, Kendall, S.L., Cox, R.A., Joanna Bacon (41305)   +63 more
core   +1 more source