Results 121 to 130 of about 5,429,710 (293)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]

, 2012
In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak, Geißler, S., Mamo, S., Horsch, Marion, Horsch, M., Andras Dinnyes, Geissler, Sandra, Mamo, Solomon, Marion Horsch, Kobolak, J., Beckers, Johannes, Solomon Mamo, Kobolak, Julianna, Dinnyes, Andras, Beckers, J., Johannes Beckers, Sandra Geißler, Dinnyes, A.   +17 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

LncRNA-mRNA expression profile and functional network of vascular dysfunction in septic rats. [PDF]

Eur J Med Res, 2023
Han YC, Shen ZJ, Wang YN, Xiang RL, Xie HZ.   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research progress on tumor-educated platelets in the diagnosis of common clinical tumors [PDF]

Zhenduanxue lilun yu shijian
Platelets not only play a crucial role in normal hemostasis and coagulation, but they are also closely associated with the occurrence, development, and metastasis of malignant tumors.
GAO Quancheng, HUANG Hui
doaj   +1 more source

CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]

, 2012
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Franch i Masferrer, Àngels, Ciudad i Gómez, Carlos Julián, Castellote i Bargalló, M. Cristina, Castell, Margarida, Noé Mata, Verónica, Rabanal i Tornero, Manel, Pelegrí i Gabaldà, Carme   +6 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cytokine mRNA-expression profile.

, 2020
(A) Alterations of cytokine mRNA-expression profile in DOX-treated KCa3.1+ mice (DOX/-DOX). (B) Cytokines with higher expression in the epidermis than in the underlying skin tissue (epidermis/ skin w/o epidermis).
Vikrant Singh (1819327), Siba P. Raychaudhuri (8550969), Javier Lozano-Gerona (4730259), Edgar Abarca-Lachen (4730256), Esther Pueyo (621869), Yolanda Gilaberte (4730250), Joaquín C. Surra (8550963), Pablo Delgado-Wicke (8550951), Hiroto Miura (431166), Pilar Giraldo (740021), Ralf Köhler (34264), Elena Tapia-Casellas (8550954), Ángeles Juarranz (3712627), Heike Wulff (127193), Brandon M. Brown (7410353), Ángel-Luis Garcia-Otín (8550960), Marta Sofía Valero (8550957), Jesús Osada (5660164), Aida Oliván-Viguera (127186), Miguel Marigil (3687664), Kirk L. Hamilton (8550966)   +20 more
core   +1 more source

Effect of introns and AT-rich sequences on expression of the bacterial hygromycin B resistance gene in the basidiomycete Schizophyllum commune [PDF]

, 2001
Previously, it was shown that introns are required for efficient mRNA accumulation in Schizophyllum commune and that the presence of AT-rich sequences in the coding region of genes can result in truncation of transcripts in this homobasidiomycete.
Scholtmeijer, K., Springer, J., Wosten, H.A.B., Scholtmeijer, K, Wessels, J.G.H., Springer, J, Wosten, HAB, Wessels, JGH   +7 more
core   +1 more source