Results 141 to 150 of about 5,749,254 (300)

Insights from Dysregulated mRNA Expression Profile of β-Cells in Response to Proinflammatory Cytokines. [PDF]

J Immunol Res, 2022
Wang Z, Huang K, Xu J, Liu J, Zheng Y.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Troxerutin, a herbal metabolite with antidiabetic and antihypercholesterolemic potential, regulates metabolic gene activity in male diabetic rats

Frontiers in Pharmacology
Background/ObjectiveThis study evaluated the antidiabetic and antihypercholesterolemic potential of the botanical metabolite troxerutin (TRX) and compared it with that of metformin in high-fat diet-fed streptozotocin-induced diabetic male Wistar rats ...
Saira Gul, Mahrukh Naseem, Irfan Shahzad Sheikh, Hafiz Muhammad Ali, Imtiaz Rabbani, Tariq Jamil, Sehar Gul, Zaid Chachar, Sana Ullah, Saima Asif, Farid Shokry Ataya, Dalia Fouad, Kasim Sakran Abass, Yuanzhe Cai, Jieren Liu, Feijuan Huang   +15 more
doaj   +1 more source

Aberrant lncRNA-mRNA expression profile and function networks during the adipogenesis of mesenchymal stem cells from patients with ankylosing spondylitis. [PDF]

Front Genet, 2022
Cen S, Cai M, Wang Y, Lu X, Chen Z, Chen H, Fang Y, Wu C, Qiu S, Liu Z.   +9 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Transformative Technology Linking Patient’s mRNA Expression Profile to Anticancer Drug Efficacy

Onco
As precision medicine such as targeted therapy and immunotherapy often have limited accessibility, low response rate, and evolved resistance, it is urgent to develop simple, low-cost, and quick-turnaround personalized diagnostic technologies for drug ...
Chen Yeh, Shu-Ti Lin, Hung-Chih Lai
doaj   +1 more source

Carcass composition, meat quality, leg muscle status, and its mRNA expression profile in broilers affected by valgus-varus deformity. [PDF]

Poult Sci, 2023
Cai C, Zhang L, Liu X, Li J, Ma Y, Jiang R, Li Z, Li G, Tian Y, Kang X, Han R.   +10 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The tissue-specific expression profile of MmeLR.

, 2013
(A) The mRNA expression levels in the five tissues from M. meretrix. The MmeLR mRNA expression levels were higher in the adductor muscle and foot than in the other three tissues, and the lowest level was in the digestive gland. Different letters indicate
Yanan You (303835), Pin Huan (195900), Baozhong Liu (303836), Xiaomei Wang (146367)   +3 more
core   +1 more source

mRNA and microRNA Expression Profile of Corneal and Conjunctival Impression Cytology Samples

Biology
Purpose: To characterize the messenger RNA (mRNA) and microRNA (miRNA) expression profiles of the normal human cornea and conjunctiva using impression cytology (IC) samples and to investigate their molecular characteristics and regulatory networks ...
Shuailin Li, Tanja Stachon, Fabian Norbert Fries, Berthold Seitz, Nicole Ludwig, Nóra Szentmáry   +5 more
doaj   +1 more source