Results 131 to 140 of about 5,749,254 (300)

RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.

PLoS ONE, 2013
Macrophage infiltration into adipose tissue is associated with obesity and the crosstalk between adipocytes and infiltrated macrophages has been investigated as an important pathological phenomenon during adipose tissue inflammation.
Yohei Sanada, Takahiro Kumoto, Haruna Suehiro, Fusanori Nishimura, Norihisa Kato, Yutaka Hata, Alexander Sorisky, Noriyuki Yanaka   +7 more
doaj   +1 more source

Integrative analyses of the mRNA expression profile reveal the involvement of STC1 in chicken folliculogenesis. [PDF]

J Anim Sci, 2023
Sun J, Zhang P, Wang D, Zhu S, Ma X, Du Z, Zhang J, Yang S, Huang H, Jiang R, Tian Y, Li W, Kang X, Yan F, Sun G, Li D.   +15 more
europepmc   +1 more source

Profiling of mRNA Expression in Quadriceps of Patients with COPD and Muscle Wasting

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2008
Peripheral muscle wasting is a feature of chronic obstructive pulmonary disease (COPD). Potent therapeutic strategies are needed to improve peripheral muscle mass in these patients. We hypothesized that the evaluation of the mRNA expression profile of quadriceps muscle could be useful in identifying key biochemical pathways involved in the wasting ...
Richard, Debigaré, François, Maltais, Claude H, Côté, Annie, Michaud, Marc-André, Caron, Mahroo, Mofarrahi, Pierre, Leblanc, Sabah N A, Hussain   +7 more
openaire   +2 more sources

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Characterization of Chicken Prolactin Regulatory Element Binding Protein and its Expression in the Anterior Pituitary Gland during Embryogenesis and Different Reproductive Stages

The Journal of Poultry Science, 2015
The PRL regulatory element binding protein (PREB) is a transcription factor that specifically binds to a Pit-1 binding element in the PRL promoter to regulate PRL gene expression in mammals.
Gen Hiyama, Norio Kansaku, Toshio Tanaka, Shin Wakui, David Zadworny   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells [PDF]

, 2010
The relationship between the expression of Steroidogenic factor 1 (Sf1) and the circadian-related gene, period homolog 2 (Per2), in the adrenal cortex is still unknown.
Toshihiko Yanase, Kouichirou Sonoda, Taijiro Okabe, Kenji Ohe, Ryoichi Takayanagi, Masatoshi Nomura, Koichi Node, Makoto Akashi, Koichi Oba, Hajime Nawata   +9 more
core  

Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients

Diseases
Amino acids (AAs) and vitamin imbalances are observed in celiac disease (CD). This study evaluated the plasma profile of vitamin A and AAs and the expression level of IL-2, IL-4, IL-10, IL-12 and TGFβ in CD patients.
Shayan Fallah, Nastaran Asri, Abdolrahim Nikzamir, Shokoufeh Ahmadipour, Amir Sadeghi, Kamran Rostami, Mohammad Rostami-Nejad   +6 more
doaj   +1 more source

[mRNA Expression Profile Changes in Angiotensin-Ⅱ-Induced Atrial Myocardial Fibrosis in Rats]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Qin Q, Lyu X, He Z, Chen L, Lu F, Li Y, Huang Y, Mo Q, Xu H, Lyu F.   +9 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source