Results 131 to 140 of about 5,429,710 (293)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Characterization of Chicken Prolactin Regulatory Element Binding Protein and its Expression in the Anterior Pituitary Gland during Embryogenesis and Different Reproductive Stages

The Journal of Poultry Science, 2015
The PRL regulatory element binding protein (PREB) is a transcription factor that specifically binds to a Pit-1 binding element in the PRL promoter to regulate PRL gene expression in mammals.
Gen Hiyama, Norio Kansaku, Toshio Tanaka, Shin Wakui, David Zadworny   +4 more
doaj   +1 more source

Integrative analyses of the mRNA expression profile reveal the involvement of STC1 in chicken folliculogenesis. [PDF]

J Anim Sci, 2023
Sun J, Zhang P, Wang D, Zhu S, Ma X, Du Z, Zhang J, Yang S, Huang H, Jiang R, Tian Y, Li W, Kang X, Yan F, Sun G, Li D.   +15 more
europepmc   +1 more source

Profiling of mRNA Expression in Quadriceps of Patients with COPD and Muscle Wasting

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2008
Peripheral muscle wasting is a feature of chronic obstructive pulmonary disease (COPD). Potent therapeutic strategies are needed to improve peripheral muscle mass in these patients. We hypothesized that the evaluation of the mRNA expression profile of quadriceps muscle could be useful in identifying key biochemical pathways involved in the wasting ...
Richard, Debigaré, François, Maltais, Claude H, Côté, Annie, Michaud, Marc-André, Caron, Mahroo, Mofarrahi, Pierre, Leblanc, Sabah N A, Hussain   +7 more
openaire   +2 more sources

Circadian expression of tryptophan hydroxylase mRNA in the chicken retina

, 1998
Many aspects of retinal physiology are controlled by a circadian clock located within the eye. This clock controls the rhythmic synthesis of melatonin, which results in elevated levels during the night and low levels during the day.
Cassone, V.M., Iuvone, P.M., Chong, Nelson W., Bernard, M., Klein, D.C.   +4 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.

PLoS ONE, 2013
Macrophage infiltration into adipose tissue is associated with obesity and the crosstalk between adipocytes and infiltrated macrophages has been investigated as an important pathological phenomenon during adipose tissue inflammation.
Yohei Sanada, Takahiro Kumoto, Haruna Suehiro, Fusanori Nishimura, Norihisa Kato, Yutaka Hata, Alexander Sorisky, Noriyuki Yanaka   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients

Diseases
Amino acids (AAs) and vitamin imbalances are observed in celiac disease (CD). This study evaluated the plasma profile of vitamin A and AAs and the expression level of IL-2, IL-4, IL-10, IL-12 and TGFβ in CD patients.
Shayan Fallah, Nastaran Asri, Abdolrahim Nikzamir, Shokoufeh Ahmadipour, Amir Sadeghi, Kamran Rostami, Mohammad Rostami-Nejad   +6 more
doaj   +1 more source

[mRNA Expression Profile Changes in Angiotensin-Ⅱ-Induced Atrial Myocardial Fibrosis in Rats]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Qin Q, Lyu X, He Z, Chen L, Lu F, Li Y, Huang Y, Mo Q, Xu H, Lyu F.   +9 more
europepmc   +1 more source