Results 91 to 100 of about 664,318 (297)

The role of the cell cycle machinery in resumption of postembryonic development [PDF]

, 2005
Cell cycle activity is required for plant growth and development, but its involvement in the early events that initiate seedling development remains to be clarified. We performed experiments aimed at understanding when cell cycle progression is activated
Barrôco, Rosa Maria, Van Poucke, Kris, Bergervoet, Jan HW, De Veylder, Lieven, Groot, Steven PC, Inzé, Dirk, Engler, Gilbert   +6 more
core   +2 more sources

Biologically relevant effects of mRNA amplification on gene expression profiles [PDF]

BMC Bioinformatics, 2006
Abstract Background Gene expression microarray technology permits the analysis of global gene expression profiles. The amount of sample needed limits the use of small excision biopsies and/or needle biopsies from human or animal tissues.
van Haaften, Rachel I. M., Schroen, Blanche, Janssen, Ben J. A., van Erk, Arie, Debets, Jacques J. M., Smeets, Hubert J. M., Smits, Jos F. M., van den Wijngaard, Arthur, Pinto, Yigal M., Evelo, Chris T. A.   +9 more
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling.

PLoS ONE, 2016
Uptake of Ca2+ into the mitochondrial matrix controls cellular metabolism and survival-death pathways. Several genes are implicated in controlling mitochondrial Ca2+ uptake (mitochondrial calcium regulatory genes, MCRGs), however, less is known about the
Nóra M Márkus, Philip Hasel, Jing Qiu, Karen F S Bell, Samuel Heron, Peter C Kind, Owen Dando, T Ian Simpson, Giles E Hardingham   +8 more
doaj   +1 more source

Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. [PDF]

PLoS ONE, 2016
BACKGROUND:Experiments in isolated perfused heart have shown that heart rate is lower and sinoatrial node (SAN) action potential duration is longer in streptozotocin (STZ)-induced diabetic rat compared to controls.
Zannatul Ferdous, Muhammad Anwar Qureshi, Petrilla Jayaprakash, Khatija Parekh, Annie John, Murat Oz, Haider Raza, Halina Dobrzynski, Thomas Edward Adrian, Frank Christopher Howarth   +9 more
doaj   +1 more source

Mycotoxins nivalenol and deoxynivalenol differently modulate cytokine mRNA expression in Jurkat T cells. [PDF]

, 2006
Deoxynivalenol (DON) and its hydroxylated form nivalenol (NIV) are Fusarium mycotoxins that occur in cereal grains alone or in combination. Several studies have shown that these metabolites affect lymphocyte functions.
BERGAMO P, LUCISANO A, LUONGO D, ROSSI M., SEVERINO, LORELLA   +4 more
core   +1 more source

Transcriptional Profiling of mRNA Expression in the Mouse Distal Colon [PDF]

Gastroenterology, 2008
Intestinal epithelial cells and the myenteric plexus of the mouse gastrointestinal tract contain a circadian clock-based intrinsic time-keeping system. Because disruption of the biological clock has been associated with increased susceptibility to colon cancer and gastrointestinal symptoms, we aimed to identify rhythmically expressed genes in the mouse
W. HOOGERWERF, M. SINHA, A. CONESA, B. LUXON, V. SHAHINIAN, G. CORNELISSEN, F. HALBERG, J. BOSTWICK, J. TIMM, V. CASSONE   +9 more
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genome-wide DNA methylation profiling integrated with gene expression profiling identifies PAX9 as a novel prognostic marker in chronic lymphocytic leukemia

Clinical Epigenetics, 2017
Background In chronic lymphocytic leukemia (CLL), epigenomic and genomic studies have expanded the existing knowledge about the disease biology and led to the identification of potential biomarkers relevant for implementation of personalized medicine. In
Lata Rani, Nitin Mathur, Ritu Gupta, Ajay Gogia, Gurvinder Kaur, Jaspreet Kaur Dhanjal, Durai Sundar, Lalit Kumar, Atul Sharma   +8 more
doaj   +1 more source

Increased expression of a microRNA correlates with anthelmintic resistance in parasitic nematodes [PDF]

, 2017
Resistance to anthelmintic drugs is a major problem in the global fight against parasitic nematodes infecting humans and animals. While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression ...
Bartley, David, Britton, Collette, Devaney, Eileen, Gillan, Victoria, Gilleard, John S., Gu, Henry, Laing, Roz, Maitland, Kirsty, Marks, Neil D., Martinelli, Axel, Morrison, Alison, Rezansoff, Andrew M., Skuce, Philip J., Winter, Alan D.   +13 more
core   +2 more sources