Results 51 to 60 of about 5,749,254 (300)
Using mRNA expression profiling to determine anticancer drug efficacy [PDF]
Cytometry, 2001 AbstractPharmacogenomics is a fast‐growing field of investigations that aims to further elucidate the inherited nature of interindividual differences in drug disposition and effects, with the ultimate goal of providing a stronger scientific basis for selecting the optimal drug therapy.
Gerrit, Los +7 more
openaire +2 more sources
Cytokine mRNA-expression profile.
, 2020 (A) Alterations of cytokine mRNA-expression profile in DOX-treated KCa3.1+ mice (DOX/-DOX). (B) Cytokines with higher expression in the epidermis than in the underlying skin tissue (epidermis/ skin w/o epidermis).
Vikrant Singh (1819327) +20 more
core +1 more source
Fluids and Barriers of the CNS, 2020 Background The complexity of the neurovascular unit (NVU) poses a challenge in the investigations of drug transport across the blood–brain barrier (BBB) and the function of the brain capillary endothelium.
C. Goldeman, B. Ozgür, B. Brodin
doaj +1 more source
Poultry ScienceThe Niemann-Pick C1-Like 1 (NPC1L1) protein, primarily expressed in the epithelial cells of the small intestine, is essential for cholesterol absorption from both dietary intake and biliary secretion.
Xin Shu +7 more
doaj +1 more source
Modification of N6-methyladenosine RNA methylation on heat shock protein expression.
PLoS ONE, 2018 This study was conducted to investigate effect of N6-methyladenosine (m6A) RNA methylation on Heat shock proteins (HSPs) and dissect the profile of HSP RNA methylation. The results showed that m6A methyltransferases METTL3 mRNA was decreased in responses
Jiayao Yu, Yi Li, Tian Wang, Xiang Zhong
doaj +1 more source
Modeling miRNA-mRNA interactions that cause phenotypic abnormality in breast cancer patients.
PLoS ONE, 2017 BackgroundThe dysregulation of microRNAs (miRNAs) alters expression level of pro-oncogenic or tumor suppressive mRNAs in breast cancer, and in the long run, causes multiple biological abnormalities.
Sanghoon Lee, Xia Jiang
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2023 Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases ...
Justin S. Antony +13 more
doaj +1 more source
Evaluating the mRNA expression profile of APC in Pterygium
Acta Medica International, 2015 Introduction: The exact etiology of pterygium is unknown. Most of population based studies implicating that pterygium has a benign behavior rather than destructive condition. Changed expression of cell cycle-related genes may lead to the abnormal cell proliferation and finally to malignancy phenotype. The aim of this study was evaluation the expression
Maryam Najafi +2 more
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery
Pharmaceutics, 2021 We previously found that a complex comprising plasmid DNA (pDNA), polyethylenimine (PEI), and γ-polyglutamic acid (γ-PGA) had high transgene efficiency without cytotoxicity in vitro and in vivo.
Eri Hamada +7 more
doaj +1 more source