Results 51 to 60 of about 11,154 (181)

Transcriptome-wide association studies: recent advances in methods, applications and available databases

Communications Biology, 2023
Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant variants has been a great task.
Jialin Mai, Mingming Lu, Qianwen Gao, Jingyao Zeng, Jingfa Xiao   +4 more
doaj   +1 more source

Demand‐Driven Mergers: Advertising, Differentiation, and Welfare

Managerial and Decision Economics, EarlyView.
ABSTRACT We consider mergers that induce demand changes. We study the firms' incentives to submit a merger request and the competition authority's decision to approve the request. We show that merger‐induced demand changes help expand settings where the interests of firms and competition authority align, whereas contexts where their interests are ...
Felix Munoz‐Garcia, Kiriti Kanjilal, Ana Espinola‐Arredondo   +2 more
wiley   +1 more source

Testing Times: A Structure/Agency Perspective on Becoming a Science Teacher in a Competitive, Exam‐Based Teacher Selection System

Science Education, EarlyView.
ABSTRACT While extensive research exists on science teacher shortages, less attention has been directed toward countries facing the opposite challenge: an oversupply of science teachers. This study examines the experiences of prospective science teachers in South Korea, where passing a high‐stakes, annual competitive examination is a prerequisite for ...
Wonyong Park, Heesoo Ha
wiley   +1 more source

From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
doaj   +1 more source

From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries

Frontiers in Genetics, 2021
Since their inception, genome-wide association studies (GWAS) have identified more than a hundred thousand single nucleotide polymorphism (SNP) loci that are associated with various complex human diseases or traits.
Binglan Li, Marylyn D. Ritchie, Marylyn D. Ritchie   +2 more
doaj   +1 more source

Integrating Artificial Intelligence With PPE: A Smart Boiler Suit Framework for Maritime Survey Applications

Safety Science and Technology, EarlyView.
This paper introduces a conceptual framework for an AI‐enhanced smart boiler suit, shifting maritime surveyor safety from reactive to proactive monitoring. Through integrated sensor networks and edge AI analytics, the proposed architecture offers a robust modular roadmap for advancing intelligent personal protective equipment in hazardous offshore and ...
P. Katsinellos, A. Gotsopoulos, A. Chatzopoulos, N. Gerolimos, G. Priniotakis   +4 more
wiley   +1 more source

Genomic inflation factor for every TWAS dataset.

, 2022
To control for false-positives, we calculated the genomic inflation factor for every TWAS dataset and used these to adjust the significance threshold for each analysis accordingly. (PDF)
Hyun Min Kang (9690325), Andrew E. Liu (12024808)   +1 more
core   +1 more source

Reassessing Environmental Performance Within ESG Frameworks: Efficiency‐Based Evidence From Multinational Firms

Thunderbird International Business Review, EarlyView.
ABSTRACT The paper explores the evolving relationship between decarbonization strategies, environmental performance within ESG frameworks, and the economic performance of multinational companies in the context of increasing environmental and geopolitical uncertainty.
Maurizio Pompella, Lorenzo Costantino
wiley   +1 more source

Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies

Arthritis Research & Therapy, 2019
Background Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.
Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang, Feng Zhang   +9 more
doaj   +1 more source

A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk

Frontiers in Genetics, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression.
Nicholas B. Larson, Shannon K. McDonnell, Zachary Fogarty, Yuanhang Liu, Amy J. French, Lori S. Tillmans, John C. Cheville, Liang Wang, Daniel J. Schaid, Stephen N. Thibodeau   +9 more
doaj   +1 more source