Results 1 to 10 of about 9,010,468 (307)

Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma.

open access: yesJAMA Oncology, 2020
Importance Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs in a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations.
L. Mirabello   +48 more
semanticscholar   +1 more source

Improving Pathogen Resistance by Exploiting Plant Susceptibility Genes in Coffee (Coffea spp.)

open access: yesAgronomy, 2020
Coffee (Coffea spp.) is an economically important crop widely cultivated in (sub) tropical countries worldwide. Commercial coffee production relies mainly on two related species, namely C. arabica and C. canephora.
Lei Cui   +3 more
doaj   +1 more source

Genetic Susceptibility of the Host in Virus-Induced Diabetes

open access: yesMicroorganisms, 2020
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID).
Keiichiro Mine   +5 more
doaj   +1 more source

Susceptibility Is New Resistance: Wheat Susceptibility Genes and Exploitation in Resistance Breeding

open access: yesAgriculture, 2022
Adapted pathogens and pests seriously threaten global wheat production. During pathogen and pest infections, wheat susceptibility (S) genes are exploited to support the compatibility of wheat with pathogens and pests.
Mengmeng Li, Zige Yang, Cheng Chang
doaj   +1 more source

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects

open access: yesGastroenterology, 2020
Background and Aims: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown.
Xing-Yi Guo   +86 more
semanticscholar   +1 more source

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

open access: yesFrontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng   +4 more
doaj   +1 more source

Germline immunoglobulin genes: disease susceptibility genes hidden in plain sight?

open access: yesCurrent Opinion in Systems Biology, 2020
Immunoglobulin genes are rarely considered as disease susceptibility genes despite their obvious and central contributions to immune function. This appears to be a consequence of historical views on antibody repertoire formation that no longer stand, and
A. Collins   +4 more
semanticscholar   +1 more source

Mining Grapevine Downy Mildew Susceptibility Genes: A Resource for Genomics-Based Breeding and Tailored Gene Editing

open access: yesBiomolecules, 2021
Several pathogens continuously threaten viticulture worldwide. Until now, the investigation on resistance loci has been the main trend to understand the interaction between grapevine and the mildew causal agents.
Carlotta Pirrello   +5 more
doaj   +1 more source

Influence of Nitrogen on Grapevine Susceptibility to Downy Mildew

open access: yesPlants, 2023
Downy mildew, caused by the obligate parasite Plasmopara viticola, is one of the most important threats to viticulture. The exploitation of resistant and susceptibility traits of grapevine is one of the most promising ways to increase the sustainability ...
Demetrio Marcianò   +9 more
doaj   +1 more source

Exploring New Routes for Genetic Resistances to Potyviruses: The Case of the Arabidopsis thaliana Phosphoglycerates Kinases (PGK) Metabolic Enzymes

open access: yesViruses, 2022
The development of recessive resistance by loss of susceptibility is a consistent strategy to combat and limit damages caused by plant viruses. Susceptibility genes can be turned into resistances, a feat that can either be selected among the plant’s ...
Mamoudou Diop, Jean-Luc Gallois
doaj   +1 more source

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