Results 41 to 50 of about 930,320 (303)

Tumor Susceptibility Genes

Cancer Control, 1998
Cancer develops and progresses as the result of accumulated genetic damage or mutations. These mutations are most commonly described as either oncogenes, which positively regulate cell growth, or tumor suppressor genes, which negatively regulate cell growth.
openaire   +2 more sources

Turning Susceptibility into Strength: A New Era of Durable Resistance in Plants Through Genome Editing

Plants
In plants, resistance genes (R) are key players in combatting diseases caused by various phytopathogens. Typically, resistance relies on detecting a single pathogen-derived molecular pattern.
Shallu Thakur, Simranjot Kaur, Sudeep Adhikari, Prerna Sabharwal, Yuqing Fu, Geoffrey Meru   +5 more
doaj   +1 more source

Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women

Cancer Biology & Medicine, 2022
Objective: There are many hereditary breast cancer patients in China, and multigene panel testing has been a new paradigm of genetic testing for these patients and their relatives.
Fenfen Fu, Dongjie Zhang, Li Hu, Senthil Sundaram, Dingge Ying, Ying Zhang, Shuna Fu, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie   +10 more
doaj   +1 more source

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Role of Jasmonic Acid Pathway in Tomato Plant-Pseudomonas syringae Interaction [PDF]

, 2020
The jasmonic acid pathway has been considered as the backbone of the response against necrotrophic pathogens. However, a hemi-biotrophic pathogen, such as Pseudomonas syringae, has taken advantage of the crosstalk between the different plant hormones in ...
García Agustín, Pilar, Llorens, Eugenio, Scalschi, Loredana, Vicedo, Begonya   +3 more
core   +1 more source

Identification of Susceptibility Genes in Castanea sativa and Their Transcription Dynamics following Pathogen Infection

Plants, 2021
Castanea sativa is one of the main multipurpose tree species valued for its timber and nuts. This species is susceptible to two major diseases, ink disease and chestnut blight, caused by Phytophthora spp. and Cryphonectria parasitica, respectively.
Vera Pavese, Andrea Moglia, Paolo Gonthier, Daniela Torello Marinoni, Emile Cavalet-Giorsa, Roberto Botta   +5 more
doaj   +1 more source

Arabidopsis defense against Botrytis cinerea : chronology and regulation deciphered by high-resolution temporal transcriptomic analysis [PDF]

, 2012
Transcriptional reprogramming forms a major part of a plant’s response to pathogen infection. Many individual components and pathways operating during plant defense have been identified, but our knowledge of how these different components interact is ...
Atwell, Susanna, Baxter, Laura, Beynon, Jim, Borgwardt, Karsten M., Breeze, Emily, Buchanan-Wollaston, Vicky, Cooke, Emma J., Denby, Katherine J., Finkenstädt, Bärbel, Hickman, Richard J., Hill, Claire, Jenkins, Dafyd J., Kiddle, Steven J., Kim, Youn-sung, Kliebenstein, Daniel James, Legaie, Roxane, Madhou, Priyadharshini, McHattie, Stuart, Mead, A., Moore, Jonathan D., Ott, Sascha, Penfold, Christopher A., Rand, D. A., Rhodes, Johanna, Stegle, Oliver, Tabrett, Alex, Wild, David L., Windram, Oliver P., Zhang, Cunjin   +28 more
core   +3 more sources

Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer

Zhongliu Fangzhi Yanjiu, 2023
Triple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period.
ZHANG Lijia, LIU Jiarui, ZHANG Yuan, CHEN Xinyu, WANG Xin, ZHANG Yi   +5 more
doaj   +1 more source

C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]

, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper, AB Singleton, AD Gitler, B Rogina, C Hertzman, CD Link, E Berezikov, E Cuppen, EA Nollen, Ellen A. A. Nollen, GM Halliday, HA Tissenbaum, HG van, HH Liou, HM Beere, JF Morley, Karen L. Thijssen, L Chen, M Kaeberlein, M Kaeberlein, M Nishimura, M Viswanathan, MC Chartier-Harlin, MG Spillantini, MG Spillantini, MH Polymeropoulos, NB Cole, PK Auluck, Rainer Breitling, Robert M. W. Hofstra, Ronald H. A. Plasterk, S Kim, S Miksys, S Roy, S Willingham, Stuart K. Kim, T Kai, TF Outeiro, Tjakko J. van Ham   +38 more
core   +8 more sources

Cardiometabolic traits mediating the effect of education on the risk of DKD and CKD: a Mendelian randomization study

Frontiers in Nutrition
BackgroundBoth diabetic kidney disease (DKD) and chronic kidney disease (CKD) are more prevalent among individuals with lower levels of education in observational studies.
Yukai Wang, Mengmeng Chen, Lin Wang, Yonggui Wu, Yonggui Wu   +4 more
doaj   +1 more source