Results 41 to 50 of about 9,010,468 (307)

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

Frontiers in Immunology, 2021
ObjectivePrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, and its pathogenetic mechanism is far from being understood. In this study, we aimed to explore the cellular and molecular mechanisms that lead to pathogenesis of this disease ...
Xiaoping Hong, Xiaoping Hong, Shuhui Meng, Donge Tang, Tingting Wang, Liping Ding, Haiyan Yu, Heng Li, Dongzhou Liu, Yong Dai, Min Yang   +10 more
doaj   +1 more source

Identifying breast cancer susceptibility genes – a review of the genetic background in familial breast cancer

Acta oncologica, 2019
Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of breast cancer is familial, referring to affected women who have one or more first- or second-degree relatives with the disease.
Camilla Wendt, S. Margolin
semanticscholar   +1 more source

Circadian gene variants and susceptibility to type 2 diabetes : a pilot study [PDF]

, 2012
Background Disruption of endogenous circadian rhythms has been shown to increase the risk of developing type 2 diabetes, suggesting that circadian genes might play a role in determining disease susceptibility.
O’Hare J. Paul, Shahrad Taheri (57360), M. Ann Kelly (174447), Shera, A. Samad, Hydrie MZ, Barnett, Anthony H., Taheri, S., Anthony H Barnett, Kumar S, Shera, A.S., Rees, Simon D., Kelly, M. Ann, Kelly, Marilyn, Shera, AS, Raychaudhuri, Soumya, Sudhesh Kumar (89490), Abdul Basit (174463), Bellary, Srikanth, Rees, S.D., Kumar, S., Barnett AH, J Paul O'Hare, M. Zafar I. Hydrie (174450), Basit, A., Bellary Srikanth, O'Hare, JP, Bellary S, Shera, A Samad, Taheri S, DIAGRAM Consortium, Hydrie, MZ, Taheri, Shahrad, M Zafar I Hydrie, Bellary, S., Abdul Basit, Hydrie M. Zafar I., Shera A. Samad, Barnett, Anthony, Bellary, S, Basit Abdul, Basit, A, Rees SD, Kumar Sudhesh, Srikanth Bellary (89487), Rees, Simon D, Sudhesh Kumar, Shahrad Taheri, O'Hare, J Paul, Rees, Simon, Kelly, M Ann, SAT2D Consortium, Hydrie, M.Z.I., Kelly MA, A Samad Shera, Basit, Abdul, Barnett, A.H., Anthony H. Barnett (174467), Rees Simon D., Kelly, M.A., Srikanth Bellary, Shera AS, Basit A, Hydrie, M Zafar I, Hydriem, Zafar L., Kumar, Sudhesh, Barnett, Anthony H, O'Hare, J.P., Kelly M. Ann, Hydrie, M. Zafar I., Simon D Rees, Kumar, S, A. Samad Shera (174452), O'Hare, J. Paul, Taheri Shahrad, Barnett Anthony H., J. Paul O’Hare (174457), M Ann Kelly, Simon D. Rees (174448)   +77 more
core   +1 more source

The genetic basis of onset age in schizophrenia: evidence and models

Frontiers in Genetics, 2023
Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population, and usually has an onset age at around 21–25 in males and 25–30 in females.
Na Zhan, Pak C. Sham, Pak C. Sham, Pak C. Sham, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Simon S. Y. Lui   +11 more
doaj   +1 more source

Family history of any cancer for childhood leukemia patients in Sweden

eJHaem, 2021
Acute lymphoblastic leukemia (ALL) is the most common childhood leukemia, while the other types, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) are much rarer.
Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki   +4 more
doaj   +1 more source

Mutation Frequency in Main Susceptibility Genes Among Patients With Head and Neck Paragangliomas

Frontiers in Genetics, 2020
Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors that have a high degree of heritability and are predominantly associated with mutations in ten genes, such as SDHx, SDHAF2, VHL, RET, NF1, TMEM127, MAX, FH, MEN2, and SLC25A11 ...
Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Dmitry V. Kalinin, Alexander L. Golovyuk, Elena A. Pudova, Zulfiya G. Guvatova, Nataliya V. Melnikova, Alexey A. Dmitriev, George S. Razmakhaev, Andrey A. Poloznikov, Galina S. Alekseeva, Andrey D. Kaprin, George S. Krasnov, Anna V. Kudryavtseva   +14 more
doaj   +1 more source

Exploration of Lung Cancer-Related Genetic Factors via Mendelian Randomization Method Based on Genomic and Transcriptomic Summarized Data

Frontiers in Cell and Developmental Biology, 2021
Lung carcinoma is one of the most deadly malignant tumors in mankind. With the rising incidence of lung cancer, searching for the high effective cures become more and more imperative.
Nitao Cheng, Xinran Cui, Chen Chen, Changsheng Li, Jingyu Huang   +4 more
doaj   +1 more source

Pathogenic and likely pathogenic variants in PALB2, CHEK2 and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer

Cancer, 2019
Breast cancer (BC) is the most common cancer and related cause of mortality among Hispanics, yet susceptibility has been understudied. BRCA1 and BRCA2 (BRCA) mutations explain less than one‐half of hereditary BC, and the proportion associated with other ...
J. Weitzel, S. Neuhausen, Aaron W Adamson, Shu Tao, C. Ricker, A. Maoz, M. Rosenblatt, Bita Nehoray, S. Sand, L. Steele, G. Unzeitig, N. Feldman, Amie M. Blanco, D. Hu, S. Huntsman, D. Castillo, C. Haiman, T. Slavin, E. Ziv   +18 more
semanticscholar   +1 more source

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type I diabetes. [PDF]

, 2005
BACKGROUND: One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 diabetes.
Undlien, Dag E, Lowe, C, Chamberlain, G, Savage, DA, Undlien, DE, Wicker, LS, Hunter, Kara M, Walker Neil, Wicker Linda S, Ionescu-Tîrgovişte, Constantin, Maier, Lisa M, Savage, David A, Fraser, H, Guja Cristian, Nutland Sarah, Vella, Adrian, Fraser, Heather, Nutland, Sarah, Moule, Carolyn, Payne, Felicity, Nutland, S, Maier, LM, Todd John A, Twells Rebecca C, Guja, Cristian, Twells, RC, Cooper, Jason D, Ionescu-Tîrgovişte Constantin, Maier Lisa M, Rønningen, Kjersti S, Payne Felicity, Moule Carolyn, Savage David A, Pask, Rebecca, Smyth Deborah J, Strachan, David P, Chamberlain Giselle, Twells, Rebecca C, Smink, LJ, Todd, John A, Hulme, J, Hunter Kara M, Vella, A, Hulme John, Hunter, KM, Lowe, Christopher, Wicker, Linda S, Walker, N, Lowe Christopher, Smyth, DJ, Peterson, LB, Smink, Luc J, Rønningen, KS, Smyth, Deborah J, Cooper Jason D, Strachan David P, Ionescu-Tîrgoviste, C, Payne, F, Pask Rebecca, Strachan, DP, Undlien Dag E, Hulme, John, Vella Adrian, Guja, C, Smink Luc J, Pask, R, Walker, Neil, Moule, C, Todd, JA, Fraser Heather, Rønningen Kjersti S, Chamberlain, Giselle, Peterson Laurence B, Cooper, JD, Peterson, Laurence B, Heather Fraser, Rebecca C Twells, Constantin Ionescu-Tîrgovişte, Adrian Vella, David P Strachan, Sarah Nutland, Luc J Smink, John A Todd, Linda S Wicker, Rebecca Pask, Kjersti S Rønningen, Lisa M Maier, Felicity Payne, Kara M Hunter, Neil Walker, Cristian Guja, John Hulme, Laurence B Peterson, Christopher Lowe, Giselle Chamberlain, Deborah J Smyth, Jason D Cooper, Dag E Undlien, Carolyn Moule, David A Savage   +99 more
core   +11 more sources

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for migraine

The Journal of Headache and Pain
Background Migraine is a common neurological disorder with a strong genetic component. Despite the identification of over 100 loci associated with migraine susceptibility through genome-wide association studies (GWAS), the underlying causative genes and ...
Jianxiong Gui, Xiaoyue Yang, Chen Tan, Ling-Man Wang, Linxue Meng, Ziyao Han, Jiehua Liu, Li Jiang   +7 more
semanticscholar   +1 more source