Results 31 to 40 of about 930,320 (303)

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

Frontiers in Immunology, 2021
ObjectivePrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, and its pathogenetic mechanism is far from being understood. In this study, we aimed to explore the cellular and molecular mechanisms that lead to pathogenesis of this disease ...
Xiaoping Hong, Xiaoping Hong, Shuhui Meng, Donge Tang, Tingting Wang, Liping Ding, Haiyan Yu, Heng Li, Dongzhou Liu, Yong Dai, Min Yang   +10 more
doaj   +1 more source

Susceptibility genes for complex epilepsy [PDF]

Human Molecular Genetics, 2005
Common idiopathic epilepsies are, clinically and genetically, a heterogeneous group of complex seizure disorders. Seizures arise from periodic neuronal hyperexcitability of unknown cause. The genetic component is mostly polygenic, where each susceptibility gene in any given individual is likely to represent a small component of the total heritability ...
Mulley, J., Scheffer, I., Harkin, L., Berkovic, S., Dibbens, L.   +4 more
openaire   +4 more sources

The genetic basis of onset age in schizophrenia: evidence and models

Frontiers in Genetics, 2023
Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population, and usually has an onset age at around 21–25 in males and 25–30 in females.
Na Zhan, Pak C. Sham, Pak C. Sham, Pak C. Sham, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Simon S. Y. Lui   +11 more
doaj   +1 more source

Tomato transcriptome and mutant analyses suggest a role for plant stress hormones in the interaction between fruit and Botrytis cinerea. [PDF]

, 2013
Fruit-pathogen interactions are a valuable biological system to study the role of plant development in the transition from resistance to susceptibility. In general, unripe fruit are resistant to pathogen infection but become increasingly more susceptible
Ann L T Powell, Barbara eBlanco-Ulate, Barbara eBlanco-Ulate, Dario eCantu, Estefania eVincenti   +4 more
core   +2 more sources

Family history of any cancer for childhood leukemia patients in Sweden

eJHaem, 2021
Acute lymphoblastic leukemia (ALL) is the most common childhood leukemia, while the other types, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) are much rarer.
Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki   +4 more
doaj   +1 more source

Mutation Frequency in Main Susceptibility Genes Among Patients With Head and Neck Paragangliomas

Frontiers in Genetics, 2020
Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors that have a high degree of heritability and are predominantly associated with mutations in ten genes, such as SDHx, SDHAF2, VHL, RET, NF1, TMEM127, MAX, FH, MEN2, and SLC25A11 ...
Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Dmitry V. Kalinin, Alexander L. Golovyuk, Elena A. Pudova, Zulfiya G. Guvatova, Nataliya V. Melnikova, Alexey A. Dmitriev, George S. Razmakhaev, Andrey A. Poloznikov, Galina S. Alekseeva, Andrey D. Kaprin, George S. Krasnov, Anna V. Kudryavtseva   +14 more
doaj   +1 more source

Exploration of Lung Cancer-Related Genetic Factors via Mendelian Randomization Method Based on Genomic and Transcriptomic Summarized Data

Frontiers in Cell and Developmental Biology, 2021
Lung carcinoma is one of the most deadly malignant tumors in mankind. With the rising incidence of lung cancer, searching for the high effective cures become more and more imperative.
Nitao Cheng, Xinran Cui, Chen Chen, Changsheng Li, Jingyu Huang   +4 more
doaj   +1 more source

Susceptibility Genes in Thyroid Autoimmunity [PDF]

Journal of Immunology Research, 2005
The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the autoimmune response to thyroid antigens.
Yoshiyuki Ban, Yaron Tomer
openaire   +3 more sources

HLA-A*11:01:01:01, HLA-C*12:02:02:01-HLA-B*52:01:02:02, Age and Sex Are Associated With Severity of Japanese COVID-19 With Respiratory Failure

Frontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19) was announced as an outbreak by the World Health Organization (WHO) in January 2020 and as a pandemic in March 2020.
Seik-Soon Khor, Yosuke Omae, Nao Nishida, Masaya Sugiyama, Noriko Kinoshita, Tetsuya Suzuki, Michiyo Suzuki, Satoshi Suzuki, Shinyu Izumi, Masayuki Hojo, Norio Ohmagari, Masashi Mizokami, Katsushi Tokunaga   +12 more
doaj   +1 more source

Circadian rhythms in insecticide susceptibility, metabolic enzyme activity, and gene expression in Cimex lectularius (Hemiptera: Cimicidae). [PDF]

, 2019
Many insect species display daily variation of sensitivity to insecticides when they are exposed to the same concentration at different times during the day. To date, this has not been investigated in bed bugs.
Doggett, Stephen L, Khalid, Muhammad Fazli, Lee, Chow-Yang, Veera Singham, G   +3 more
core   +3 more sources