Results 31 to 40 of about 9,010,468 (307)

Clustered Regularly Interspaced Short Palindromic Repeats-Associated Protein System for Resistance Against Plant Viruses: Applications and Perspectives

Frontiers in Plant Science, 2022
Different genome editing approaches have been used to engineer resistance against plant viruses. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas; CRISPR/Cas) systems to create pinpoint genetic ...
Fredy D. A. Silva, Elizabeth P. B. Fontes   +1 more
doaj   +1 more source

Genomic Analysis Highlights Putative Defective Susceptibility Genes in Tomato Germplasm

Plants, 2023
Tomato (Solanum lycopersicum L.) is one of the most widely grown vegetables in the world and is impacted by many diseases which cause yield reduction or even crop failure.
Ruiling Li, Alex Maioli, Sergio Lanteri, Andrea Moglia, Yuling Bai, Alberto Acquadro   +5 more
doaj   +1 more source

The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? [PDF]

, 2013
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial.
Ebert, Dieter, Dieter Ebert, Matthew D Hall, Hall, Matthew D., Ebert D, Hall MD   +5 more
core   +1 more source

IRGM variants and susceptibility to inflammatory bowel disease in the German population. [PDF]

, 2013
Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD susceptibility ...
Darina Czamara, Seiderer, J., Goke, B., Eleni Tsekeri (276693), Stephanie Bues, Fries, C., Julia Seiderer (107820), Beigel, F., Glas, J., Friedrich, Matthias, Christian Steib (174731), Czamara, D., Jürgen Glas (107816), Stephanie Bues (276692), Bues, S., Eleni Tsekeri, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Florian Beigel (174724), Beigel, Florian, Matthias Friedrich (174721), Stallhofer, J., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Steib, Christian, Göke, Burkhard, Fries, Christoph, Friedrich, M., Seiderer, Julia, Glas, Jürgen, Tsekeri, E., Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Martin Wetzke, Burkhard Göke, Christian Steib, Stephan Brand, Tsekeri, Eleni, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Julia Diegelmann (107830), Bues, Stephanie, Jürgen Glas, Wetzke, Martin, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten, Seiderer Julia, Tsekeri Eleni, Diegelmann Julia, Fries Christoph, Friedrich Matthias, Steib Christian, Bues Stephanie, Brand Stephan, Olszak Torsten, Beigel Florian, Wetzke Martin, Göke Burkhard, Stallhofer Johannes, Czamara Darina, Glas Jürgen   +74 more
core   +2 more sources

Identification of candidate genes for dyslexia susceptibility on chromosome 18 [PDF]

, 2010
Background: Six independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage.
Pennington Bruce F., Anthony P. Monaco, Alex J. Richardson, Richard K. Olson, Alex J Richardson, Joel Talcott, Bruce F Pennington, Morris Andrew, Olson Richard K., Silvia Paracchini, Anthony P Monaco, Thomas S Scerri, Smith, Shelley D., Richardson, Alex J., I Laurence MacPhie, Stein, John, Shelley D. Smith, Pennington, Bruce F., Monaco, Anthony P., Paracchini, Silvia, John Stein, Stein, John F., Scerri Thomas S., MacPhie I. Laurence, Talcott, Joel B., I. Laurence MacPhie, Andrew Morris, John C. DeFries, Talcott Joel, Morris, Andrew, Smith Shelley D., Talcott, Joel, Bruce F. Pennington, Monaco Anthony P., Olson, Richard K., MacPhie, I. Laurence, DeFries, John C., DeFries John C., Shelley D Smith, Stein John, John C DeFries, Richard K Olson, Paracchini Silvia, Thomas S. Scerri, Scerri, Thomas S., Paracchini, Silvia; id_orcid   +45 more
core   +1 more source

Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry. [PDF]

, 2010
BACKGROUND: Autism spectrum disorders (ASDs) are a group of highly heritable neurodevelopmental disorders which are characteristically comprised of impairments in social interaction, communication and restricted interests/behaviours.
Klauck, Sabine M., Monaco, Anthony P, Klauck, Sabine M, Bailey, Anthony J., Bailey Anthony J, Poustka Fritz, Bailey, Anthony J, Pagnamenta Alistair T, Fritz Poustka, Mulder, Erik J., Alistair T Pagnamenta, Battaglia Agatino, Taane G Clark, Clark, Taane Gregrory, Mulder Erik J, Clark, Taane G., Pagnamenta, Alistair T, Minderaa Ruud B, Klauck Sabine M, Sousa, Inês, Anthony P Monaco, Monaco Anthony P, Erik J Mulder, null null, Clark, Taane G, Monaco, Anthony P., Ruud B Minderaa, Pagnamenta, Alistair T., Minderaa, Ruud B., Inês Sousa, Holt, Richard, International Molecular Genetic Study of Autism Consortium (IMGS, Richard Holt, Anthony J Bailey, Clark Taane G, Minderaa, Ruud B, Battaglia, Agatino, Sabine M Klauck, Agatino Battaglia, Holt Richard, Mulder, Erik J, Sousa Inês, Poustka, Fritz   +42 more
core   +1 more source

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease [PDF]

, 2005
Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31).
Tenesa, Albert, Anderson, Norman, Satsangi, Jack, Nimmo, Elaine R, Drummond, Hazel, Ho, Gwo-Tzer, Arnott, Ian D R, Noble, Colin L, Smith, Linda   +8 more
core   +1 more source

Inactivation of tomato WAT1 leads to reduced susceptibility to Clavibacter michiganensis through downregulation of bacterial virulence factors

Frontiers in Plant Science, 2023
Tomato bacterial canker caused by Clavibacter michiganensis (Cm) is considered to be one of the most destructive bacterial diseases of tomato. To date, no resistance to the pathogen has been identified. While several molecular studies have identified (Cm)
Eleni Koseoglou, Eleni Koseoglou, Katharina Hanika, Mas M. Mohd Nadzir, Wouter Kohlen, Jan M. van der Wolf, Richard G. F. Visser, Yuling Bai   +7 more
doaj   +1 more source

Engineering tomato disease resistance by manipulating susceptibility genes [PDF]

Frontiers in Genome Editing
Md Sazan Rahman, Palash Mandal, Duoduo Wang   +2 more
exaly   +2 more sources

A transcriptome-wide association study of high grade serous epithelial ovarian cancer identifies novel susceptibility genes and splice variants

Nature Genetics, 2019
We sought to identify susceptibility genes for high-grade serous ovarian cancer (HGSOC) by performing a transcriptome-wide association study of gene expression and splice junction usage in HGSOC-relevant tissue types (N = 2,169) and the largest genome ...
Alexander Gusev, K. Lawrenson, Xianzhi Lin, P. Lyra, S. Kar, K. C. Vavra, Felipe D. Segato, Marcos A. S. Fonseca, Janet M. Lee, T. Pejovic, Gang Liu, B. Karlan, M. Freedman, H. Noushmehr, A. Monteiro, P. Pharoah, B. Pasaniuc, S. Gayther, O. Consortium   +18 more
semanticscholar   +1 more source