Results 31 to 40 of about 583,132 (315)

The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease [PDF]

open access: yes, 2005
Recent data suggest that polymorphisms in the organic cation transporter (OCTN) genes OCTN1 (SLC22A4) and OCTN2 (SLC22A5) represent disease-causing mutations within the IBD5 locus (chromosome 5q31).
Arnott, IDR   +17 more
core   +1 more source

Inactivation of tomato WAT1 leads to reduced susceptibility to Clavibacter michiganensis through downregulation of bacterial virulence factors

open access: yesFrontiers in Plant Science, 2023
Tomato bacterial canker caused by Clavibacter michiganensis (Cm) is considered to be one of the most destructive bacterial diseases of tomato. To date, no resistance to the pathogen has been identified. While several molecular studies have identified (Cm)
Eleni Koseoglou   +7 more
doaj   +1 more source

A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd [PDF]

open access: yes, 2011
Associations between specific host genes and susceptibility to Mycobacterial infections such as tuberculosis have been reported in several species. Bovine tuberculosis (bTB) impacts greatly the UK cattle industry, yet genetic predispositions have yet to ...
Driscol, E.   +26 more
core   +1 more source

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

open access: yesFrontiers in Immunology, 2021
ObjectivePrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, and its pathogenetic mechanism is far from being understood. In this study, we aimed to explore the cellular and molecular mechanisms that lead to pathogenesis of this disease ...
Xiaoping Hong   +10 more
doaj   +1 more source

The genetic basis of onset age in schizophrenia: evidence and models

open access: yesFrontiers in Genetics, 2023
Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population, and usually has an onset age at around 21–25 in males and 25–30 in females.
Na Zhan   +11 more
doaj   +1 more source

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity [PDF]

open access: yes, 2012
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls.
Kang, HM   +879 more
core   +1 more source

Family history of any cancer for childhood leukemia patients in Sweden

open access: yeseJHaem, 2021
Acute lymphoblastic leukemia (ALL) is the most common childhood leukemia, while the other types, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) are much rarer.
Xinjun Li   +4 more
doaj   +1 more source

The Susceptibility Genes in Diabetic Nephropathy [PDF]

open access: yesKidney Diseases, 2018
<b><i>Background:</i></b> Diabetes mellitus (DM) poses a severe threat to global public health. Diabetic nephropathy (DN) is one of the most common complications of diabetes and the leading cause of end-stage renal disease (ESRD).
Ling, Wei   +6 more
openaire   +2 more sources

Mutation Frequency in Main Susceptibility Genes Among Patients With Head and Neck Paragangliomas

open access: yesFrontiers in Genetics, 2020
Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors that have a high degree of heritability and are predominantly associated with mutations in ten genes, such as SDHx, SDHAF2, VHL, RET, NF1, TMEM127, MAX, FH, MEN2, and SLC25A11 ...
Anastasiya V. Snezhkina   +14 more
doaj   +1 more source

Exploration of Lung Cancer-Related Genetic Factors via Mendelian Randomization Method Based on Genomic and Transcriptomic Summarized Data

open access: yesFrontiers in Cell and Developmental Biology, 2021
Lung carcinoma is one of the most deadly malignant tumors in mankind. With the rising incidence of lung cancer, searching for the high effective cures become more and more imperative.
Nitao Cheng   +4 more
doaj   +1 more source

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