Results 51 to 60 of about 930,320 (303)

Associations of genetic variants contributing to gut microbiota composition in diabetic nephropathy

Frontiers in Endocrinology, 2023
IntroductionThe gut microbiota is strongly associated with multiple kidney diseases, and since microbial composition is heritable, we hypothesized that genetic variations controlling gut microbiota composition were associated with diabetic nephropathy ...
Xiao Lu, Junjun Ma, Lili Guo, Wei Wu, Rongshan Li   +4 more
doaj   +1 more source

Genomic insights into the rapid emergence and evolution of MDR in Staphylococcus pseudintermedius. [PDF]

, 2014
OBJECTIVES: MDR methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains have emerged rapidly as major canine pathogens and present serious treatment issues and concerns to public health due to their, albeit low, zoonotic potential. A further
A. J. McCarthy, A. Loeffler, A. Waller, B. Leggett, Bannoehr, Besier, Black, Bond, Croucher, D. H. Lloyd, Darling, De Lucia, E. M. Harrison, Feil, Feng, Geoghegan, Gortel, J. A. Lindsay, K. Stanczak-Mrozek, Kadlec, Koser, Loeffler, Loeffler, M. A. Holmes, Magiorakos, Noguchi, Prescott, Quail, Roberts, Ruscher, Rutherford, Soedarmanto   +31 more
core   +3 more sources

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

Eukaryotic translation initiation factor 4E family member nCBP facilitates the accumulation of TGB-encoding viruses by recognizing the viral coat protein in potato and tobacco

Frontiers in Plant Science, 2022
Due to their limited coding capacity, plant viruses have to depend on various host factors for successful infection of the host. Loss of function of these host factors will result in recessively inherited resistance, and therefore, these host factors are
Ruhao Chen, Ruhao Chen, Manhua Yang, Zhen Tu, Fangru Xie, Jiaru Chen, Tao Luo, Xinxi Hu, Bihua Nie, Changzheng He   +9 more
doaj   +1 more source

The cumulative effects of known susceptibility variants to predict primary biliary cirrhosis risk. [PDF]

, 2015
Multiple genetic variants influence the risk for development of primary biliary cirrhosis (PBC). To explore the cumulative effects of known susceptibility loci on risk, we utilized a weighted genetic risk score (wGRS) to evaluate whether genetic ...
Bian, Z, Chen, H, Feng, X, Gershwin, M, Invernizzi, P, Liao, Wilson, Ma, W, Ma, X, Miao, Q, Seldin, M, Tang, R   +10 more
core   +2 more sources

Genes Influencing Susceptibility to Infection [PDF]

The Journal of Infectious Diseases, 2008
In this issue of the Journal, an article [1] reports the results of a human genome scan for quantitative trait loci (QTLs) influencing susceptibility to Ascaris lumbricoides.Theworkisimportantbothforthe insight that it provides into how the body resistsheavyinfectionwiththisimportant soil-transmitted intestinal helminth and for what it promises in this
William A , Petri, Beth D, Kirkpatrick, Rashidul, Haque, Priya, Duggal   +3 more
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

A Transcriptome‐Wide Association Study Identifies Candidate Susceptibility Loci and Genes for Lung Cancer Risk

Cancer Medicine
Background Genome‐wide association studies (GWAS) have identified over 80 susceptibility loci for lung cancer risk. However, the genes underlying these associations remain largely unknown. Methods We conducted a large transcriptome‐wide association study
Tianying Zhao, Jiajun Shi, Yaohua Yang, Dan Zhou, Jie Ping, Shuai Xu, Lili Xu, Jie Wu, Xiao‐Ou Shu, Ran Tao, Bingshan Li, Wei Zheng, Jirong Long, Qiuyin Cai   +13 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis

Bone & Joint Research, 2023
AimsDegenerative cervical spondylosis (DCS) is a common musculoskeletal disease that encompasses a wide range of progressive degenerative changes and affects all components of the cervical spine.
Jiawen Xu, Haibo Si, Yi Zeng, Yuangang Wu, Shaoyun Zhang, Yuan Liu, Mingyang Li, Bin Shen   +7 more
doaj   +1 more source