Results 51 to 60 of about 9,010,468 (307)

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.

open access: yesJournal of Clinical Oncology, 2018
PURPOSE The aim of the current study was to determine the prevalence and clinical predictors of germline cancer susceptibility mutations in patients with malignant mesothelioma (MM).
V. Panou   +24 more
semanticscholar   +1 more source

Analysis of IL12B gene variants in inflammatory bowel disease [PDF]

open access: yes, 2012
IL12B encodes the p40 subunit of IL-12, which is also part of IL-23. Recent genome-wide association studies identified IL12B and IL23R as susceptibility genes for inflammatory bowel disease (IBD).
Darina Czamara   +79 more
core   +2 more sources

Turning Susceptibility into Strength: A New Era of Durable Resistance in Plants Through Genome Editing

open access: yesPlants
In plants, resistance genes (R) are key players in combatting diseases caused by various phytopathogens. Typically, resistance relies on detecting a single pathogen-derived molecular pattern.
Shallu Thakur   +5 more
doaj   +1 more source

HLA-A*11:01:01:01, HLA-C*12:02:02:01-HLA-B*52:01:02:02, Age and Sex Are Associated With Severity of Japanese COVID-19 With Respiratory Failure

open access: yesFrontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19) was announced as an outbreak by the World Health Organization (WHO) in January 2020 and as a pandemic in March 2020.
Seik-Soon Khor   +12 more
doaj   +1 more source

A preliminary study of genetic factors that influence susceptibility to bovine tuberculosis in the British cattle herd [PDF]

open access: yes, 2011
Associations between specific host genes and susceptibility to Mycobacterial infections such as tuberculosis have been reported in several species. Bovine tuberculosis (bTB) impacts greatly the UK cattle industry, yet genetic predispositions have yet to ...
Driscol, E.   +26 more
core   +1 more source

Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women

open access: yesCancer Biology & Medicine, 2022
Objective: There are many hereditary breast cancer patients in China, and multigene panel testing has been a new paradigm of genetic testing for these patients and their relatives.
Fenfen Fu   +10 more
doaj   +1 more source

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity [PDF]

open access: yes, 2012
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls.
Kang, HM   +875 more
core   +1 more source

Relationship Between Nonalcoholic Fatty Liver Disease Susceptibility Genes and Coronary Artery Disease

open access: yesHepatology Communications, 2019
Coronary artery disease (CAD) is the principal cause of death in patients with nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to investigate whether NAFLD is causally involved in the pathogenesis of CAD.
M. Brouwers   +5 more
semanticscholar   +1 more source

Identification of Susceptibility Genes in Castanea sativa and Their Transcription Dynamics following Pathogen Infection

open access: yesPlants, 2021
Castanea sativa is one of the main multipurpose tree species valued for its timber and nuts. This species is susceptible to two major diseases, ink disease and chestnut blight, caused by Phytophthora spp. and Cryphonectria parasitica, respectively.
Vera Pavese   +5 more
doaj   +1 more source

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, and shows evidence for additional susceptibility genes

open access: yesNature Genetics, 2009
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date.
D. Harold   +86 more
semanticscholar   +1 more source

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