Results 71 to 80 of about 545,336 (266)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Ornamental Plant ResearchImpatiens downy mildew is a highly destructive disease of Impatiens walleriana, an economically important bedding ornamental crop. This disease is caused by a recently emerged pathogen Plasmopara obducens.
Stephanie Suarez +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Search for schizophrenia susceptibility genes
Biological Psychiatry, 2000 Identification of a gene or genes that contribute to the development of schizophrenia, a complex psychiatric disorder, may be possible through genetic linkage analysis. Although to date no single causative gene has been identified, several chromosomal loci have shown positive linkage results and are under investigation as tentative schizophrenia ...
openaire +2 more sources
Editorial: Genetic features contributing to eye development and disease
Frontiers in Cell and Developmental Biology, 2022 Wenchang Xu +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Genética de la esquizofrenia: avances en el estudio de genes candidatos
Revista de Biología Tropical, 2004 La esquizofrenia es una de las enfermedades mentales severas que afecta a un 1% de la población mundial. Es claro que en su etiología participan factores genéticos y ambientales.
Adriana Pacheco, Henriette Raventós
doaj
Psicofarmacogenética: uma nova abordagem terapêutica
Brazilian Journal of Psychiatry, 1999 A psicofarmacogenética é uma nova área de investigação derivada da psicofarmacologia e da genética. Esta disciplina procura identificar genes de suscetibilidade associados a diferentes padrões de resposta terapêutica e/ou ao variado grau de efeitos ...
Homero Pinto Vallada Filho
doaj +1 more source