Results 71 to 80 of about 9,010,468 (307)

Eukaryotic translation initiation factor 4E family member nCBP facilitates the accumulation of TGB-encoding viruses by recognizing the viral coat protein in potato and tobacco

Frontiers in Plant Science, 2022
Due to their limited coding capacity, plant viruses have to depend on various host factors for successful infection of the host. Loss of function of these host factors will result in recessively inherited resistance, and therefore, these host factors are
Ruhao Chen, Ruhao Chen, Manhua Yang, Zhen Tu, Fangru Xie, Jiaru Chen, Tao Luo, Xinxi Hu, Bihua Nie, Changzheng He   +9 more
doaj   +1 more source

Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

Schizophrenia bulletin, 2018
Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a polygenic disorder determined by numerous genetic variants but with small effect size.
M. Ikeda, A. Takahashi, Y. Kamatani, Y. Momozawa, T. Saito, Kenji Kondo, Ayu Shimasaki, Kohei Kawase, T. Sakusabe, Y. Iwayama, T. Toyota, Tomoyasu Wakuda, M. Kikuchi, N. Kanahara, H. Yamamori, Y. Yasuda, Y. Watanabe, Satoshi Hoya, B. Aleksic, I. Kushima, H. Arai, M. Takaki, K. Hattori, H. Kunugi, Y. Okahisa, T. Ohnuma, N. Ozaki, T. Someya, R. Hashimoto, T. Yoshikawa, M. Kubo, N. Iwata   +31 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis

Bone & Joint Research, 2023
AimsDegenerative cervical spondylosis (DCS) is a common musculoskeletal disease that encompasses a wide range of progressive degenerative changes and affects all components of the cervical spine.
Jiawen Xu, Haibo Si, Yi Zeng, Yuangang Wu, Shaoyun Zhang, Yuan Liu, Mingyang Li, Bin Shen   +7 more
doaj   +1 more source

Genome Editing: Targeting Susceptibility Genes for Plant Disease Resistance.

Trends in Biotechnology, 2018
Plant pathogens pose a major threat to crop productivity. Typically, phytopathogens exploit plants' susceptibility (S) genes to facilitate their proliferation.
Syed Shan-e-Ali Zaidi, M. Mukhtar, S. Mansoor   +2 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Germline RECQL gene mutations in Chinese patients with breast cancer

Frontiers in Medicine
IntroductionBreast cancer is the most common malignant tumor in women, seriously threatening health and survival. TP-dependent DNA helicase Q1 (RECQL) is a breast cancer susceptibility gene with possible familial links.
Jun Hu, Jun Hu, Yong Shen, Kun Zhang, Yiding Chen   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk

npj Breast Cancer, 2017
Understanding the gene-specific risks for development of breast cancer will lead to improved clinical care for those carrying germline mutations in cancer predisposition genes.
T. Slavin, Kara N. Maxwell, J. Lilyquist, J. Vijai, S. Neuhausen, S. Hart, Vignesh Ravichandran, Tinu Elizabeth Thomas, Ann Maria, D. Villano, K. Schrader, R. Moore, Chun-Ling Hu, B. Wubbenhorst, Brandon M. Wenz, K. D'Andrea, M. Robson, P. Peterlongo, B. Bonanni, J. Ford, J. Garber, S. Domchek, C. Szabo, K. Offit, K. Nathanson, J. Weitzel, F. Couch   +26 more
semanticscholar   +1 more source