Results 71 to 80 of about 583,132 (315)

Germline RECQL gene mutations in Chinese patients with breast cancer

Frontiers in Medicine
IntroductionBreast cancer is the most common malignant tumor in women, seriously threatening health and survival. TP-dependent DNA helicase Q1 (RECQL) is a breast cancer susceptibility gene with possible familial links.
Jun Hu, Jun Hu, Yong Shen, Kun Zhang, Yiding Chen   +4 more
doaj   +1 more source

Susceptibility genes of hyperuricemia and gout

Hereditas, 2022
AbstractGout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most important risk factor for gout.
Yue-Li Nian, Chong-Ge You
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. [PDF]

, 2009
Kawasaki disease (KD) is a pediatric vasculitis that damages the coronary arteries in 25% of untreated and approximately 5% of treated children. Epidemiologic data suggest that KD is triggered by unidentified infection(s) in genetically susceptible ...
Nievergelt, Caroline M., Sundel R.P., Li Y., Ng, S.B., Dillon, M, Shulman, ST, Sarah B Ng, Odam M., Nissan, M, Newburger, Jane W., Shimizu, C, Curtis, Nigel, Jane C Burns, Shike, Hiroko, Bonnard C., Burns, JC, Sundel, Robert P., Dillon, Michael, Bose, A, Kuijpers, Taco W., Burgner, D., Victoria J. Wright, Nissen, Michael, D., Burns Jane C., Shingadia D., Schork, NJ, Witt C., Kuijpers, Taco W, Wright, V.J., Kuipers, IM, Ling, L, Sarah B. Ng, Sonia Davila, Kuijpers, TW, Davila, S, Burgner, David, Ling, L., Odam, M., Breunis, W.B., Bonnard, C., Michie, C, Curtis, N, Ng S.B., Odam, Miranda, Burgner D., Hibberd, ML, Brogan P., Thalamuthu, A., Ziegler, J, Shah, Vanita, Shulman, Stanford T., Wright Victoria J., Ling L., Palasanthiran P., Rowley A.H., Ottenkamp, Jaap J., Breunis W.B., Shah V., Nissan, Michael, Filippini, L, Thalamuthu A., Carine Bonnard, Kuijpers T.W., Tulloh R., Christiansen F., Nourse C., Miranda Odam, Breunis, Willemijn B., Goldwater, P, Filippini L., Klein, Nigel, Biezeveld M., Mukasa, Thomas, Wright, Victoria J, Levin, Michael, Hibberd, M.L., Ng, SB, Curtis N., Thalamuthu, Anbupalam, Li Yi, Nissan M., Kuipers I.M., Rowley, AH, Kuijpers, T.W., Breunis, Willemijn B, Booy R., Dillon M., Rowley, Anne H., Kuipers, Irene M., Levin Michael, Davila, S., Davila Sonia, Booy, Robert, Schork N.J., Nourse, Clare, Li, Y, Shimizu, Chisato, Ng Sarah B., Tulloh, Robert, Consortium, IKDG, Goldwater, Paul, Nievergelt C.M., Bose A., Filippini, Luc, Christiansen, Frank, Li, Y., Ziegler, John, Shulman S.T., Bonnard, C, Geissler J., Burgner David, Willemijn B. Breunis, Ng, Sarah B., Breunis Willemijn B., Martin L Hibberd, Hibberd M.L., Palasanthiran, P, Ling, Ling, Witt, C, Christiansen, F, Breunis, WB, Burns J.C., Shah, V, Burns, Jane C., Hibberd, Martin L., Michie C., Burgner, D, Baker, Annette L., Ottenkamp, JJ, Taco W Kuijpers, Levin, M, Geissler, J, Mukasa, T, Shimizu C., Davila, Sonia, Bose, Anu, Levin, M., Bonnard Carine, Odam Miranda, Nievergelt, CM, Li, Yi, Brugner, David, Jane C. Burns, Davila S., Baker, AL, Ng, Sarah B, Newburger, JW, Baker A.L., Newburger J.W., Willemijn B Breunis, Shike, H, Burns, J.C., Michie, Colin, Biezeveld, Maarten, Hibberd, Martin L, Wright, Victoria J., Biezeveld, M, Levin M., Shingadia, D, Kuijpers Taco W., Martin L. Hibberd, Thalamuthu Anbupalam, Shike H., Wright, VJ, Shimizu Chisato, Ziegler J., Shingadia, Delane, Ottenkamp J.J., Yi Li, Klein N., Geissler, Judy, Burns, Jane C, International Kawasaki Disease Genetics Consortium, Palasanthiran, Pamela, Ling Ling, Taco W. Kuijpers, Wright V.J., Tulloh, R, Bonnard, Carine, Sundel, RP, Shimizu, C., Schork, Nicholas J., Goldwater P., Brogan, P, Mukasa T., Brogan, Paul, Hibberd Martin L., Victoria J Wright, Odam, M, Thalamuthu, A, Witt, Campbell, Michael Levin, David Burgner, Chisato Shimizu, Anbupalam Thalamuthu, Klein, N, Booy, R, Nourse, C   +197 more
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Susceptibility Genes to Plant Viruses [PDF]

Viruses, 2018
Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Candidate genes colocalized to linkage regions in inflammatory bowel disease [PDF]

, 2002
Background and Aims: The genes encoding for tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor receptor (EGFR) and the vitamin D receptor (VDR) are colocalized to inflammatory bowel disease-associated linkage regions on chromosomes 6, 7 and
Folwaczny, Christian, Radimayr, M., Heinzlmann, M., Borchers, R., Martin, K.   +4 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample [PDF]

, 2011
Rationale: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits,
Shrine, Nick, McArdle, W. L., Caroline Hayward (149856), Zaboli, Ghazal, Sayers, Ian, Anneli Pouta, Surakka, I., Palmer, L.J., Igor Rudan (150101), Mangino, M., Ruth J. F. Loos, Nicholas J Wareham (7665416), Zgaga, Lina, Elliott, Paul, Zhai, G., David Hadley (220412), Rudnicka, AR, Joachim Heinrich (60421), Huffman, J., Huffman, JE, Wilmar Igl (149869), Rudnicka, Alicja R., Huffman, Jennifer E., Kaprio, Jaakko, Lina Zgaga (149875), Stipan Jankovic, Ozren Polašek (149888), Glaeser, S, Loos, Ruth J F, Heinrich, Joachim, David M. Evans, Jennifer E. Huffman (7665404), Probst-Hensch, Nicole M, Palmer, Lyle J., Johansson, Asa, Paul R. Burton (7581164), Martin D. Tobin, Paul R. Burton, Evans, DM, Wild, SH, David P Strachan, Louise V. Wain (7588511), Igl, W., Imboden, M., Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Surakka, Ida, Consortium, SM, Koch, B., Wright, Alan F, Louise V Wain, Tim D. Spector (7588592), Homuth, G, Linda Mustelin (220425), Gyllensten, Ulf,, Campbell, Harry; id_orcid, Granell, Raquel, Strachan, David P., Jarvelin, M.R., Henry Völzke (64286), Zhao, J.-H., Johnson, T, Ramasamy, A, Lyle J. Palmer (7665407), Taina Rantanen, Johnson, T., ?, ?, Zhao, Jing Hua, Arthur William Musk (7665422), Repapi, Emmanouela, et al., Ida Surakka (120325), Imboden, Medea, Gyllensten, U., Grkovic, I., Obeidat, Ma’en, Nick Shrine (220391), Vitart, Veronique, Ruth J.F. Loos (7665413), Johansson, Åsa,, Nick Shrine, Ghazal Zaboli, Musk, AW, Huffman, Jennifer E, Probst-Hensch, NM, Maria Soler Artigas (7634069), Wright, A.F., Hadley, D., Tobin, M.D., Nicole M. Probst-Hensch (7634162), Stipan Jankovic (220423), Ozren Polašek, Loos, Ruth J.F., Eva Albrecht (174584), Wareham, N.J., Mangino, M, Guangju Zhai (110167), Ulf Gyllensten, Ian P. Hall (7377620), Probst-Hensch, Nicole M., Nicholas J Wareham, Alan F. Wright, Hartikainen, A.-L., Nicholas J. Wareham, Hall, I.P., Loos, Ruth J. F., Soler Artigas, M., Artigas, M.S., Burton, P.R, Zgaga, L, Johansson, Å, Tim D Spector, Medea Imboden, Hall, I. P., Wain, Louise V., Raquel Granell, Raquel Granell (123318), Ida Surakka, Henderson, John, Jankovic, S, Loos, RJF, Jennifer E. Huffman, McArdle, Wendy L., Wilson, James F, Loos, R. J. F., Palmer, Lyle J, Koch, B, Jennie Hui, Palmer, L., Gyllensten, Ulf, Kalsheker, N., Völzke, H, Paul Elliott, Artigas, Maria Soler, Probst-Hensch, N.M., Homuth, G., Deloukas, P., Eva Albrecht, Henderson, J, Rantanen, T., Jankovic, S., Wright, AF, Glaser, Sven, Toby Johnson, Palmer, LJ, Zaboli, G, Martin D Tobin, Marjo-Riitta Jarvelin (110290), Wareham, N. J., Zgaga, L., Wareham, NJ, Wright, Alan F., Toby Johnson (43283), Polaek, O., Anna-Liisa Hartikainen, Nicole M Probst-Hensch, Polasek, Ozren, Ruth J F Loos, Polasek, O., Jarvelin, MR, Jankovic, Stipan, Adaikalavan Ramasamy, Louise V. Wain, Jing Hua Zhao, Wild, Sarah H; id_orcid, Hall, IP, Huffman, J. E., Homuth, Georg, Wild, Sarah H, Deloukas, Panos, Harry Campbell (30339), Obeidat, M, Wareham, Nicholas J., Grkovic, Ivica, Rudan, I., Musk, A.W., Barroso, Ines, Burton, P. R., Alicja R. Rudnicka (7665410), Tim D. Spector, Wilson, James F., Sven Gläser, Maria Soler Artigas, Ulf Gyllensten (13773), Zhao, J.H., Zhao, JH, SpiroMeta Consortium, Hartikainen, A. L., Shrine, N, Vitart, V, Alicja R. Rudnicka, Zhao, J. H., Evans, David M., Hayward, C, Voelzke, Henry, Igl, W, Wilmar Igl, Panos Deloukas (21564), Lina Zgaga, Strachan, DP, Repapi, E, Hadley, David, Elliott, P., Polašek, O, Spector, TD, Palmer, L. J., Wain, L., Igor Rudan, Ivica Grkovic, Ramasamy, A., Marjo-Riitta Jarvelin, Ma'en Obeidat, Evans, D.M., Igl, Wilmar,, Panos Deloukas, Ma'en Obeidat (110232), Adaikalavan Ramasamy (4841), Hartikainen, A.L., Massimo Mangino (87550), Inês Barroso (2144), Gyllensten, U, Strachan, D. P., Henry Völzke, Tobin, MD, Wain, LV, Jaakko Kaprio (43154), Deloukas, P, Anneli Pouta (116626), Mustelin, L., Obeidat, Ma'en, Hui, J., SpiroMeta Consortium,, Spector, T. D., Hayward, C., Campbell, H, Campbell, Harry, Rudnicka, A.R., SpiroMeta Consortium (), Alicja R Rudnicka, Wright, A. F., Probst-Hensch N. M.,, Burton, Paul R., Cadby, Gemma, Noor Kalsheker, Gläser, S., Heinrich, J., Soranzo, N, Ramasamy, Adaikalavan, Sven Gläser (110276), Wain, L. V., Spector, Tim D., Zhai, G, Emmanouela Repapi, Kaprio, J., Åsa Johansson, Hartikainen, AL, Beate Koch (110151), Rantanen, Taina, Linda Mustelin, Pouta, Anneli, David P. Strachan, Wareham, Nicholas J, Georg Homuth (110202), Tobin, M. D., Barroso, I., Jennifer E Huffman, SpiroMeta Consortium (220429), Guangju Zhai, Artigas, MS, Noor Kalsheker (220393), Musk, A. W., Soler Artigas M.,, Alan F. Wright (7665419), John Henderson (123324), Jarvelin, M-R, Wilson, J.F., Obeidat, M., Grkovic, I, Jing Hua Zhao (7634084), Soranzo, N., Burton, P., Mangino, Massimo, Pouta, A., Rudnicka, A. R., Zaboli, Ghazal,, Völzke, Henry, Lyle J Palmer, Ghazal Zaboli (174959), Granell, R., Campbell, H., Hadley, D, Heinrich, J, Wild, S.H., Gemma Cadby (174601), Martin D. Tobin (7581161), Cadby, G, Zhai, Guangju, Jarvelin, M. R., James F Wilson, Wilson, James F; id_orcid, Zaboli, G., Kaprio, J, Alan F Wright, Massimo Mangino, Medea Imboden (110145), Caroline Hayward, Albrecht, E., Harry Campbell, Wendy L. McArdle, Strachan, D.P., Surakka, I, Musk, Arthur William, Cadby, G., Wain, L.V., Arthur William Musk, Veronique Vitart, Taina Rantanen (200021), Shrine, N., Sarah H. Wild (7512197), Pouta, A, Rudan, Igor, Nicole Soranzo (12361), Huffman, J.E., Mustelin, Linda, Soler Artigas, Maria, Rantanen, T, Åsa Johansson (84687), Veronique Vitart (149854), David P. Strachan (7634177), Nicole M. Probst-Hensch, McArdle, W.L., James F. Wilson (7638917), Inês Barroso, Wilson, J. F., Gläser, S, Burton, Paul R, Sarah H. Wild, Soranzo, Nicole, Hayward, Caroline, Gemma Cadby, Evans, D. M., Völzke, H., Johnson, Toby, Sayers, I., Elliott, P, Wendy L. McArdle (7634075), Igl, Wilmar, Wild, S. H., Burton, PR, Voelzke, H, Emmanouela Repapi (220397), Jennie Hui (220409), Kalsheker, Noor, Nicole Soranzo, McArdle, Wendy L, David M Evans, Lyle J. Palmer, Loos, RJ, Glaeser, Sven, Spector, Tim D, Sarah H Wild, Johansson, A., Imboden, M, Ian Sayers, Hui, Jennie, Ian P Hall, Hui, J, Granell, R, Cadby,Gemma, Henderson, J., McArdle, WL, Soler Artigas, M, Barroso, I, Sayers, I, Albrecht, E, Hartikainen, A-L, Koch, Beate, Ian P. Hall, Georg Homuth, Paul R Burton, Kalsheker, N, John Henderson, Spector, T.D., Jaakko Kaprio, James F. Wilson, Ivica Grkovic (220420), Wilson, JF, Mustelin, L, Repapi, E., Loos, R.J., Rudan, I, David Hadley, Wild, Sarah H., Beate Koch, David M. Evans (7190417), Vitart, V., Ian Sayers (37266), Joachim Heinrich, Paul Elliott (27295), Albrecht, Eva, Hall, Ian P., Tobin, Martin D., Hayward, Caroline; id_orcid, Wain, Louise V, Rudnicka, Alicja R, Wendy L McArdle, Anna-Liisa Hartikainen (110272)   +406 more
core   +1 more source