Results 81 to 90 of about 583,132 (315)

Melanoma Genomics

Acta Dermato-Venereologica, 2020
The incidence of cutaneous melanoma continues to increase in pale skinned peoples in Europe and elsewhere. Epidemiological studies identified genetically determined phenotypes such as pale skin, freckles and red hair, and sunburn as risk factors for this
Julia Newton-Bishop, D. Timothy Bishop, Mark Harland   +2 more
doaj   +1 more source

Autism: in search of susceptibility genes.

Neuromolecular medicine, 2002
Autism is a neurodevelopmental disorder of unknown etiology. There is convincing data for the involvement of genetic factors in the development of autism, and the absence of any consistent evidence for an environmental, neuroanatomical, or biochemical cause has led to an increasing number of genetic studies to determine the basis of this complex ...
Lamb, Janine A.; id_orcid 0000-0002-7248-0539, Parr, Jeremy R., Bailey, Anthony J., Monaco, Anthony P.   +3 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

in melanoma susceptibility [PDF]

, 2016
We applied a targeted sequencing approach to identify germline mutations conferring a moderately to highly increased risk of cutaneous and uveal melanoma.
Unneberg, Per, Muyi Yang, Hildur Helgadottir, Engstrom, Par G., Linden, Diana, Per Unneberg, Kjellqvist, Sanela,, Edsgard, Daniel, Helgadottir, Hildur, Diana Lindén, Engstrom, Pär G.,, Eriksson, Hanna, Hanna Eriksson, Sanela Kjellqvist, Hoiom, Veronica, Hansson, Johan, Johan Hansson, Pär G. Engström, Edsgärd, Daniel,, Kjellqvist, Sanela, Unneberg, Per,, Daniel Edsgärd, Tuominen, Rainer, Veronica Höiom, Rainer Tuominen, Yang, Muyi   +25 more
core   +1 more source

Identification of a T1D Susceptibility Gene [PDF]

The Scientific World JOURNAL, 2001
It is not known what causes type 1 diabetes (T1D), which affects over 1 million people in the U.S. alone. Each year, 30,000 young people in the U.S. develop this disease and depend on insulin injections thereafter. Because of the huge cost to the individual, the family, and to society in increased health care costs, it is important to find what makes ...
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian [PDF]

, 2009
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China.
Guang Wang, Zhi-Xie Zhang, Qin Yin, Jia Ma, Fuhou Chang, Min-jie Wang, Jun QI   +6 more
core   +1 more source

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. [PDF]

, 2010
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of
Seiderer, J., Seiderer Julia, Folwaczny, M., Ochsenkühn, Thomas, Fries, C., Beigel, F., Klein, Wolfram, Glas, J., Müller-Myhsok, B., Folwaczny Matthias, Darina Roeske, Matthias Folwaczny, Bertram Müller-Myhsok, Göke, Burkard, Jörg T Epplen, Epplen Jörg T., Diegelmann Julia, Fries Christoph, Melinda Nagy, Pfennig Simone, Brand, Stephan, Nagy, M., Göke, B., Brand Stephan, Nagy, Melinda, Thomas Ochsenkühn, Weidinger Maria, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Klein, Wolfgang, Epplen, Jörg T., Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Göke, Burkhard, Fries, Christoph, Folwaczny, Matthias, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Roeske, Darina, Glas, Jürgen, Epplen, J., Diegelmann, J., Lohse, P., Christoph Fries, Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Burkhard Göke, Göke Burkhard, Klein, W., Stephan Brand, Maria Weidinger, Roeske Darina, Brand, S., Jürgen Glas, Klein Wolfram, Roeske, D., Lohse, Peter, Diegelmann, Julia, Nagy Melinda, Simone Pfennig, Wolfram Klein, Glas Jürgen, Florian Beigel, Lohse Peter, Julia Seiderer   +69 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source