Results 101 to 110 of about 9,010,468 (307)

Research Progress on Rice-Blast-Resistance-Related Genes

Plants
As a staple food crop, Oryza sativa L. is not only the basis of global food and nutrition security but also an important cornerstone of national economic development and social stability.
Biaobiao Cheng, Beibei Lv, Qiangbing Xuan, Yunfang Li, Jing Li, Weihong Liang, Junjie Wang   +6 more
doaj   +1 more source

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

Molecular Metabolism, 2017
Objectives Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments have been ...
F. Ndiaye, Ana Ortalli, M. Canouil, Marlène Huyvaert, Clara Salazar-Cardozo, C. Lecoeur, M. Verbanck, V. Pawlowski, R. Boutry, E. Durand, Iandry Rabearivelo, O. Sand, L. Marselli, J. Kerr-Conte, V. Chandra, R. Scharfmann, O. Poulain-Godefroy, P. Marchetti, F. Pattou, A. Abderrahmani, P. Froguel, A. Bonnefond   +21 more
semanticscholar   +1 more source

Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population

, 2017
Background: Many osteoarthritis (OA) susceptibility genes have been identified in recent years. Given the overlap in the phenotype of joint inflammation between OA and Kashin-Beck disease (KBD), the aim of this study is to explore whether the reported OA
Yang, ZL (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China., Liu, X, Ma, S, Yang, ZL (reprint author), Chinese Acad Sci, Sichuan Translat Med Res Hosp, Chengdu, Sichuan, Peoples R China., Lin, H, Yang, ZL (reprint author), Sichuan Prov Peoples Hosp, 32 First Ring Rd West 2, Chengdu 610072, Sichuan, Peoples R China., Yang, ZL (reprint author), Univ Elect Sci & Technol China, Sch Med, Chengdu, Sichuan, Peoples R China., Lu, F, Cheng, J, Tai, ZF, Li, YF, Yang, ZL (reprint author), Hosp Univ Elect Sci & Technol China, Ctr Human Mol Biol & Genet, 32 First Ring Rd West 2, Chengdu 610072, Sichuan, Peoples R China., Yang, ZL (reprint author), Hosp Univ Elect Sci & Technol China, Key Lab Human Dis Gene Study, Chengdu, Sichuan, Peoples R China., Huang, LL, Shi, Y, Yang, ZL   +15 more
core   +1 more source

SnTox3 acts in effector triggered susceptibility to induce disease on wheat carrying the Snn3 gene [PDF]

, 2009
The necrotrophic fungus Stagonospora nodorum produces multiple proteinaceous host-selective toxins (HSTs) which act in effector triggered susceptibility.
McDonald, B., McDonald Megan C., Nunez, A., Faris Justin D., Liu, Z., Zhaohui Liu, Friesen Timothy L., Tan, Kar-Chun, Oliver, R.P., Faris, Justin D., Kar-Chun Tan, Oliver, Richard P., Rasmussen, Jack B., Lu Shunwen, Solomon Peter S., Richard P Oliver, Friesen, T., Tan, K.C., Megan C McDonald, McDonald, M., Oliver Richard P., Bruce A McDonald, Friesen, T.L., Jack B Rasmussen, McDonald, Megan C., McDonald, Megan C.; id_orcid, Faris, J.D., Peter S Solomon, Liu Zhaohui, Nunez, Alberto, McDonald, Bruce A., Rasmussen, J., Rasmussen Jack B., Friesen, Timothy L., Faris, J., McDonald Bruce A., Oliver, Richard, Liu, Zhaohui, McDonald, B.A., Rasmussen, J.B., Nunez Alberto, Solomon, Peter S., Tan Kar-Chun, Timothy L Friesen, Solomon, P., McDonald, M.C., Lu, S., Shunwen Lu, Justin D Faris, Alberto Nunez, Lu, Shunwen, Solomon, P.S.   +51 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Association analysis of CCL5, P2RX7, and SP110 gene polymorphisms with inactive pulmonary tuberculosis

Frontiers in Cellular and Infection Microbiology
BackgroundHost genetic background plays a crucial role in Mycobacterium tuberculosis infection and the development of pulmonary tuberculosis. This study aims to investigate the association between the polymorphisms of the CCL5, P2RX7, and SP110 genes and
Fengting Chen, Haitao Wang, Junfeng Ren, Jifeng Cao, Chong Liu, Shanying Tong, Changdong Wu   +6 more
doaj   +1 more source

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

Biological Research, 2017
Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes.
L. Jara, Sebastian Morales, Tomás de Mayo, P. González-Hormazábal, Valentina Carrasco, R. Godoy   +5 more
semanticscholar   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Whole-exome sequencing reveals Kawasaki disease susceptibility genes and their association with coronary artery lesion

Frontiers in Pediatrics
ObjectiveThis study aimed to explore Kawasaki disease (KD) susceptibility genes and their complications like coronary artery lesions (CAL) using whole exome sequencing (WES).MethodsBetween April 1, 2021, and December 31, 2022, our study included 55 ...
Yazhou Wang, Xuepeng Chen, Dufei Zhang, Renwei Chen, Ailixiati Alifu   +4 more
doaj   +1 more source

Allele-specific methylation of type 1 diabetes susceptibility genes.

Journal of Autoimmunity, 2017
The susceptibility to autoimmune diseases is influenced by genes encoding major histocompatibility complex (MHC) proteins. By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of CpG ...
Alida Kindt, R. Fuerst, Jan Knoop, M. Laimighofer, T. Telieps, M. Hippich, Maria A. Woerheide, S. Wahl, R. Wilson, Eva-Maria Sedlmeier, A. Hommel, J. Todd, J. Krumsiek, A. Ziegler, E. Bonifacio   +14 more
semanticscholar   +1 more source