Results 111 to 120 of about 9,010,468 (307)

Susceptibility Genes in Thyroid Autoimmunity [PDF]

, 2005
The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary
Yaron Tomer, Yoshiyuki Ban
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Disease spectrum of gastric cancer susceptibility genes

, 2021
Pathogenic variants in germline cancer susceptibility genes can increase the risk of a large number of diseases. Our study aims to assess the disease spectrum of gastric cancer susceptibility genes and to develop a comprehensive resource of gene–disease ...
Hughes, Kevin S., Braun, Danielle, Mullen, John T., Yin, Kanhua, McKinley, Sophia K., Pathak, Kush, McKinley, Sophia K, Bao, Yujia, Singh, Preeti, Mullen, John T, Zhou, Jingan, Hughes, Kevin S, Wang, Jin, Wu, Menghua, John T. Mullen, Yujia Bao, Jin Wang, Kanhua Yin, Menghua Wu, Preeti Singh, Kevin S. Hughes, Kush Pathak, Danielle Braun, Jingan Zhou, Sophia K. McKinley   +24 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

An xa5 Resistance Gene-Breaking Indian Strain of the Rice Bacterial Blight Pathogen Xanthomonas oryzae pv. oryzae Is Nearly Identical to a Thai Strain

Frontiers in Microbiology, 2020
The rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) constrains production in major rice growing countries of Asia. Xoo injects transcription activator-like effectors (TALEs) that bind to and activate host “susceptibility” (S) genes ...
Sara C. D. Carpenter, Prashant Mishra, Chandrika Ghoshal, Prasanta K. Dash, Li Wang, Samriti Midha, Gouri S. Laha, Jagjeet S. Lore, Wichai Kositratana, Nagendra K. Singh, Kuldeep Singh, Prabhu B. Patil, Ricardo Oliva, Sujin Patarapuwadol, Adam J. Bogdanove, Rhitu Rai   +15 more
doaj   +1 more source

Genetic Susceptibility to Vitiligo: GWAS Approaches for Identifying Vitiligo Susceptibility Genes and Loci

Frontiers in Genetics, 2016
Vitiligo is an autoimmune disease with a strong genetic component, characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Genetic factors are known to play key roles in vitiligo through discoveries in association studies
Chang-Bing Shen, Jing Gao, Y. Sheng, Jin-Fa Dou, Fu-Sheng Zhou, Xiao-Dong Zheng, Randy F. Ko, Xian-Fa Tang, Cai-Hong Zhu, Xian-Yong Yin, Liang-Dan Sun, Yong Cui, Xue-Jun Zhang   +12 more
semanticscholar   +1 more source

in melanoma susceptibility

, 2016
We applied a targeted sequencing approach to identify germline mutations conferring a moderately to highly increased risk of cutaneous and uveal melanoma.
Unneberg, Per, Muyi Yang, Hildur Helgadottir, Engstrom, Par G., Linden, Diana, Per Unneberg, Kjellqvist, Sanela,, Edsgard, Daniel, Helgadottir, Hildur, Diana Lindén, Engstrom, Pär G.,, Eriksson, Hanna, Hanna Eriksson, Sanela Kjellqvist, Hoiom, Veronica, Hansson, Johan, Johan Hansson, Pär G. Engström, Edsgärd, Daniel,, Kjellqvist, Sanela, Unneberg, Per,, Daniel Edsgärd, Tuominen, Rainer, Veronica Höiom, Rainer Tuominen, Yang, Muyi, Engstrom, PG, Kjellqvist, S,, Helgadottir, H,, Tuominen, R,, Linden, D, Eriksson, H,, Unneberg, P, Hansson, J,, Yang, M,, Edsgard, D   +35 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population. [PDF]

, 2012
The Brazilian Amazon is a hypo-endemic malaria region with nearly 300,000 cases each year. A variety of genetic polymorphisms, particularly in erythrocyte receptors and immune response related genes, have been described to be associated with ...
Rockett, Kirk A., Campino Susana, Martha Cecília Suarez-Mutis, Martha Cecília Suarez-Mutis (164115), Simone da Silva Santos, Santos, Simone da Silva, Fernandes, Octavio, Dominic P. Kwiatkowski (106264), Susana Campino, Kirk A Rockett, Kirk A. Rockett (138127), Rockett, Kirk A, Octavio Fernandes (16216), Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Campino, Susana, da Silva Santos Simone, Taane G. Clark (106263), Susana Campino (56411), Clark, Taane G., Rockett Kirk A., Suarez-Mutis, Martha Cecília, Clark Taane G., Octavio Fernandes, Simone da Silva Santos (164105), Kwiatkowski, Dominic P., Suarez-Mutis Martha Cecília, da Silva Santos, Simone, Clark, Taane G, Kwiatkowski, Dominic P, Fernandes Octavio   +31 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source