Results 131 to 140 of about 583,132 (315)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Susceptibility genes in thyroid autoimmunity [PDF]

, 2020
The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g.
BAN, & YARON TOMER Yoshiyuki
core  

Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. [PDF]

, 2007
Rare inactivating mutations in BRCA1, BRCA2, ATM, TP53 and CHEK2 confer relative risks for breast cancer between about 2 and more than 10, but more common variants in these genes are generally considered of little or no clinical significance.
dos Santos Silva, Isabel, Gibson, Lorna, Webb, Emily, Gabrielle Sellick, Lorna Gibson, Houlston, Richard, Nichola Johnson, Peto, Julian, Johnson, Nichola, Fletcher, Olivia, Claire Palles, Sean V. Tavtigian, Agnes Fraser, Rudd, Matthew, Ashworth, Alan, Isabel Dos Santos Silva, Palles, Claire, McCormack, Valerie, Tavtigian, Sean V, Leonard, Angela, Alan Ashworth, Valerie Mccormack, Gilham, Clare, Emily Webb, Richard Houlston, Sellick, Gabrielle, Olivia Fletcher, Matthew Rudd, Angela Leonard, Clare Gilham, Fraser, Agnes, Julian Peto   +31 more
core   +1 more source

Gene-gene interactions in gastrointestinal cancer susceptibility

Oncotarget, 2016
Cancer arises from complex, multi-layer interactions between diverse genetic and environmental factors. Genetic studies have identified multiple loci associated with tumor susceptibility. However, little is known about how germline polymorphisms interact with one another and with somatic mutations within a tumor to mediate acquisition of cancer traits.
Kim, Jineun, Yum, Seoyun, Kang, Changwon, Kang, Suk-Jo   +3 more
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Genetics of ischaemic stroke among persons of non-European descent: A meta-analysis of eight genes involving; 32,500 individuals [PDF]

, 2007
Ischaemic stroke in persons of European descent has a genetic basis, but whether the stroke-susceptibility alleles, the strength of any association, and the extent of their attributable risks are the same in persons of non-European descent remains ...
Whittaker, John, Sharma, Pankaj, Juan P Casas, Casas Juan P, Hingorani Aroon D, Ariyaratnam Roshan, Ariyaratnam, R, Smeeth Liam, Casas, Juan P, John Whittaker, Liam Smeeth, Whittaker, J, Aroon D Hingorani, Sharma Pankaj, Hingorani, AD, Ariyaratnam, Roshan, Whittaker John, Smeeth, Liam, Casas, JP, Pankaj Sharma, Hingorani, Aroon D, Sharma, P, Roshan Ariyaratnam, Smeeth, L   +23 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A genome wide linkage search for breast cancer susceptibility genes [PDF]

, 2006
Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome-wide linkage screens, which
Kraan, Jaennelle, Szabo, Csilla, Hopper, John L., Futreal, P. Andrew, Vasen, Hans F. A., Klijn, Jan G.M, Andrulis, Irene, Seal, Sheila, Smith, Paula, Lynch, Henry, Mangion, Jon, Chenevix-Trench, Georgia, Wooster, Richard, Easton, Douglas F., Baskcomb, Linda, Klijn, Jan G. M., McCredie, Margaret R.E., Edkins, Sarah, Pupo, Gulietta M., Rapley, Elizabeth, Newman, Beth, Stratton, Michael R., Cornelisse, Cees J., McCredie, Margaret R. E., Giles, Graham G., Odefrey, Fabrice, van Asperen, Christi, Hall, Anita, Renard, Hélène, Couch, Fergus, Kroeze-Jansema, Karin, Barfoot, Rita, Buys, Saundra, Newman, Beth M., Klijn, Jan G.M., Eccles, Diana, Chang-Claude, Jenny, Goldgar, David E., Vasen, Hans F.A., Mann, Graham J., Southey, Melissa, McGuffog, Lesley, Devilee, Peter, Oldenburg, Rogier, Weber, Barbara L., Meijers-Heijboer, Hanne, Senie, Ruby, Rahman, Nazneen, van Leeuwen, Inge, Stoppa-Lyonnet, Dominique, Nathanson, Katherine L., Evans, D. Gareth   +51 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source