Results 131 to 140 of about 9,010,468 (307)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Psicofarmacogenética: uma nova abordagem terapêutica

Brazilian Journal of Psychiatry, 1999
A psicofarmacogenética é uma nova área de investigação derivada da psicofarmacologia e da genética. Esta disciplina procura identificar genes de suscetibilidade associados a diferentes padrões de resposta terapêutica e/ou ao variado grau de efeitos ...
Homero Pinto Vallada Filho
doaj   +1 more source

Identification of candidate MLO powdery mildew susceptibility genes in cultivated Solanaceae and functional characterization of tobacco NtMLO1

Transgenic research, 2015
Specific homologs of the plant Mildew Locus O (MLO) gene family act as susceptibility factors towards the powdery mildew (PM) fungal disease, causing significant economic losses in agricultural settings.
Michela Appiano, Stefano Pavan, D. Catalano, Zheng Zheng, Valentina Bracuto, C. Lotti, R. Visser, L. Ricciardi, Yu-Ling Bai   +8 more
semanticscholar   +1 more source

Comparison between the differentially upregulated and downregulated genes in the pEAE mice and MS susceptibility genes.

, 2016
(A) Venn diagram depicting the common genes between MS susceptibility genes (Hoppmann et al., [74]) and upregulated EAE genes (34) and the common genes between the MS susceptibility genes and downregulated EAE genes (4).
Ioanna Sevastou (438645), Gareth Pryce (468644), David L. Selwood (468649), David Baker (11642)   +3 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Candidate DNA Repair Susceptibility Genes Identified by Exome Sequencing in High-Risk Pancreatic Cancer

Cancer Letters, 2015
The genetic basis underlying the majority of hereditary pancreatic adenocarcinoma (PC) is unknown. Since DNA repair genes are widely implicated in gastrointestinal malignancies, including PC, we hypothesized that there are novel DNA repair PC ...
A. L. Smith, N. Alirezaie, Ashton A. Connor, M. Chan-Seng-Yue, R. Grant, Iris Selander, C. Bascuñana, A. Borgida, A. Hall, T. Whelan, S. Holter, Treasa A. McPherson, S. Cleary, G. Petersen, A. Omeroglu, E. Saloustros, J. Mcpherson, L. Stein, W. Foulkes, J. Majewski, S. Gallinger, G. Zogopoulos   +21 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Strain of an Emerging Indian Xanthomonas oryzae pv. oryzae Pathotype Defeats the Rice Bacterial Blight Resistance Gene xa13 Without Inducing a Clade III SWEET Gene and Is Nearly Identical to a Recent Thai Isolate

Frontiers in Microbiology, 2018
The rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) injects transcription activator-like effectors (TALEs) that bind and activate host “susceptibility” (S) genes important for disease.
Sara C. D. Carpenter, Prashant Mishra, Chandrika Ghoshal, Prasanta K. Dash, Li Wang, Samriti Midha, Gouri S. Laha, Jagjeet S. Lore, Wichai Kositratana, Nagendra K. Singh, Kuldeep Singh, Prabhu B. Patil, Ricardo Oliva, Sujin Patarapuwadol, Adam J. Bogdanove, Rhitu Rai   +15 more
doaj   +1 more source

Genome-Wide Transcriptome Directed Pathway Analysis of Maternal Pre-Eclampsia Susceptibility Genes

PLoS ONE, 2015
Background Preeclampsia (PE) is a serious hypertensive pregnancy disorder with a significant genetic component. Numerous genetic studies, including our own, have yielded many susceptibility genes from distinct functional groups.
H. Yong, P. Melton, Matthew P. Johnson, K. Freed, B. Kalionis, P. Murthi, S. Brennecke, R. Keogh, E. Moses   +8 more
semanticscholar   +1 more source

Genes involved in susceptibility to B. cinerea.

, 2014
Genes involved in susceptibility to B. cinerea.
Mathilde Fagard (145254), François Perreau (575543), Claudine Balagué (575544), Stefania Del Prete (575541), Stéphanie Boutet-Mercey (575542), Clémentine Le Roux (231313), Dominique Roby (234767), Valérie Gaudin (231334)   +7 more
core   +1 more source