Results 141 to 150 of about 9,010,468 (307)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

New susceptibility Loci associated with kidney disease in type 1 diabetes [PDF]

, 2012
Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation.
Benjamin J. Keller (135013), Swan, E.J., Zerbini, G., Huang H., Savage, D.A., Groop L., He, Bing, Martin, Finian, Maxwell, Alexander P., Lefebvre P., Claes Ladenvall (135128), Isakova Tamara, Rosengård-Bärlund, Milla, Maestroni S., Cimponeriu Danut, Bing He, Ahola, A., Claes Ladenvall, Gill, G.V., Raija Lithovius (135051), Syreeni A., Ahola, Aila J., Aila J Ahola, Tregouet, David-Alexandre, Palmer, C., McKnight Amy Jayne, Emma Ahlqvist (135003), Kretzler M., Joel N Hirschhorn, Markku Lehto (135047), Kustaa Hietala (135040), Möllsten Anna, Anne-May Osterholm, Soro-Paavonen, A., McKnight, Amy Jayne, Robert L. Hanson (135175), Hosseini S. Mohsen, Hirschhorn, Joel, Österholm Anne-May, Tregouet David-Alexandre, Groop Leif, Groop, L., Kretzler, M., Taylor Andrew, Stavarachi Monica, Martin Finian, Eugen Mota, Böger C.A., Kustaa Hietala, Heikkilä O., Hanson, R.L., Maxwell, Alexander P; id_orcid, Tolonen Nina, Zerbini G., Bain, Stephen C., Kytö, Janne, He, Bin, Ahlqvist Emma, Hosseini, S.M., Wadén, Johan, Wadén J., Robert L Hanson, Cinzia Sarti, Groop Per-Henrik, Mollsten, Anna, Williams W.W., Cristian Serafinceanu, Andrew D Paterson, Mirel, Daniel B, Gu, Tianwei, Rigalleau V., Isakova T., Harjutsalo V., Pierre Lefebvre, Gordin D., Nina Tolonen, Syreeni, Anna, Bull S.B., Alhenc-Gelas, F., Lahermo Päivi, Boright, Andrew P, Raija Lithovius, Salem, Rany M., Keller, B., Candace Guiducci (135108), Mihai Ioana (135158), Soro-Paavonen Aino, Deshmukh H.A., Hans-Henrik Parving (135117), Sadlier, D., Österholm A.-M., Ahola Aila J., Saraheimo, Markku, Sarah Prior, Denise M Sadlier, Bing He (135034), Tregouet D.-A., Tolonen, Nina Emilia, Groop P.-H., Tikkanen, H., Palmer, Cameron, et al., Boright, A.P., Florez, Jose, Gianpaolo Zerbini, Aino Soro-Paavonen, Mota, E., Lahermo, Päivi, Hietala, Kustaa, Ladenvall, Claes, Swan E.J., Groop, Per-Henrik, Stavarachi M., Brismar, Kerstin, Williams, W., Thorn, L.M., Maria Mota (135162), Hirschhorn Joel N., Maestroni Silvia, Alhenc-Gelas, Francois, David A Savage, Harshal A. Deshmukh (135008), Söderlund Jenny, Osterholm, Anne-May, Paterson, Andrew D., Alexander P Maxwell, Waggott, D., Mäkinen, Ville-Petteri, Guiducci Candace, Salem R.M., Milla Rosengård-Bärlund (135064), McKay, Gareth J., Rosengård-Bärlund Milla, Savage D.A., Jaakko Tuomilehto, Rossing, P., Aino Soro-Paavonen (135070), Lithovius Raija, Maestroni, Silvia, David-Alexandre Tregouet (4350982), Silvia Maestroni, Rigalleau Vincent, Monica Stavarachi, DCCT/EDIC Research Group, Fagerholm E., Lehto M., Alexander P. Maxwell (135219), Rossing Peter, Prior S., Alhenc-Gelas F., McKnight, A.J., Danut Cimponeriu (135155), Henrik Falhammar, Hietala K., Fagerholm Emma, Markku Saraheimo, Deshmukh, H.A., François Alhenc-Gelas (135130), Möllsten A., Deshmukh Harshal A., Jenny Söderlund, Kytö Janne, Boright, Andrew P., Tarnow, Lise, Maestroni, S., Ahola, Aila, Tryggvason Karl, Rigalleau, Vincent, Jose C. Florez (114792), Ronan Roussel (101806), Elizabeth J. Swan (134990), Gordin Daniel, Prior Sarah, Williams, Winfred W., Salem, Rany M, Kretzler Matthias, Nelson R.G., Pitkäniemi J., Lund University., Mirel Daniel B., Söderlun, Jenny, Hans-Henrik Parving, Catherine Godson, Ronan Roussel, Ahlqvist E., Forsblom, C., David-Alexandre Tregouet, Heikkilä, Outi, Panduru Nicolae Mircea, Karl Tryggvason, Bull, S.B., Rossing, Peter, Cinzia Sarti (135068), Gill G.V., Keller, Benjamin J., McKnight, A., Brennan, E., Keller, B.J., Johan Wadén (135095), Bain Stephen C., Hadjadj S., Keller, Benjamin J, Hietala Kustaa, Lehto Markku, Matthias Kretzler (135179), McKnight, Amy Jayne; id_orcid, Gill, Geoffrey V, Tryggvason K., Gill Geoffrey V., Tamara Isakova, Lahermo P., Ahola, Aila J, Päivi Lahermo (95619), Guiducci C., Prior, S., Nicolae Mircea Panduru, Boright Andrew P., Serafinceanu Cristian, Andrew P Boright, Daniel B Mirel, Gu Tianwei, Godson, C., Maxwell A.P., Taylor, Andrew, Maxwell, A.P., Emma Fagerholm, Ville-Petteri Mäkinen, Roussel R., Harjutsalo, Valma, Heikki Tikkanen, Tryggvason, K., Mirel, Daniel B., Tolonen N., Carol Forsblom (134970), Sarti, C., Hosseini, S. Mohsen, Henrik Falhammar (135149), Huang, H., Saraheimo Markku, Parkkonen, Maija, Catherine Godson (93633), Soro-Paavonen, Aino, Tarnow, L., Mäkinen Ville-Petteri, Tikkanen Heikki, Lajer M., Amy Jayne McKnight (134964), Sadlier, Denise M., Lefebvre, P., Andrew Taylor, McKay Gareth J., Hosseini S.M., Sarti, Cinzia, Heikki Tikkanen (135079), Tuomilehto J., Bain, S.C., Martin, F., Mota, Maria, Fagerholm, Emma, Tianwei Gu (135152), Sadlier, Denise M, Per-Henrik Groop, Peter Rossing, Tarnow L., Maija Parkkonen, Sadlier Denise M., Per-Henrik Groop (135217), Milla Rosengård-Bärlund, Ville-Petteri Mäkinen (74272), Eugen Mota (135165), Florez J.C., Rany M. Salem (134961), Gareth J McKay, Daryl Waggott (135190), Parving H.-H., Joel N. Hirschhorn (131545), Leif Groop (12005), Ahlqvist, Emma, Syreeni Anna, Ahlqvist, Emma,, Gu, Harvest F., S. Mohsen Hosseini (135113), Anna Maestroni (135141), Pierre Lefebvre (135133), Serafinceanu C., Zerbini, Gianpaolo, Emma Fagerholm (135023), Winfred W. Williams (134981), Vincent Rigalleau, Peter Rossing (135121), Anna Möllsten (135153), Robert G. Nelson (135177), Niina Sandholm (134957), Ladenvall Claes, Palmer C., Fagerholm, E., Forsblom C., Guiducci, Candace, Deshmukh, H., Eoin P. Brennan (134968), Heikkila, O., Ahola A.J., He B., Rosengård-Bärlund M., Williams, Winfred, Gill, Geoffrey V., Lise Tarnow (135125), Anna Syreeni, Florez Jose C., Gianpaolo Zerbini (135187), Eoin P Brennan, Harshal A Deshmukh, Andrew D. Paterson (135194), Jaakko Tuomilehto (65635), McKay, Gareth J; id_orcid, Cimponeriu, Danut, Stavarachi, Monica, Mäkinen, V., Cameron Palmer, Kerstin Brismar (135185), Sandholm, Niina, Valma Harjutsalo (135029), Cameron Palmer (134993), Lefebvre, Pierre, Kyto, J., Thorn Lena M., Parving, Hans-Henrik, Prior, Sarah, Ladenvall C., Lena M. Thorn (135076), Deshmukh, Harshal A, Nelson, Robert G., Anna Syreeni (135072), Hadjadj Samy, Salem, R., Heikkilä Outi, Godson, Catherine, Maria Lajer (135188), Harvest F Gu, Pitkäniemi, Janne, Lithovius, Raija, Maija Parkkonen (135059), Isakova, T., Lehto, Markku, Waggott, Daryl, Bull Shelley B., Harjutsalo Valma, Lena M Thorn, Mirel, D.B., Aila J. Ahola (135020), Roussel Ronan, Mollsten, Anna,, Tolonen, Nina, Päivi Lahermo, Deshmukh, Harshal A., Ahlqvist, E., Hadjadj, S., Rigalleau, V., Outi Heikkilä, Danut Cimponeriu, Sadlier D.M., Swan, E., Gu H.F., Wadén Johan, Swan, Elizabeth J, Groop, Leif,, Panduru, Nicolae Mircea, Mäkinen, V.P., Hanson, Robert L., Paterson A.D., Daryl Waggott, Maria Mota, Daniel Gordin, Söderlund J., Bain S.C., Forsblom, Carol, Falhammar Henrik, Maxwell Alexander P., Rossing P., Helen M Colhoun, Marre Michel, Mota M., Pitkäniemi, Janne Mikael, Prior, Sarah Virginie, Janne Pitkäniemi, Carol Forsblom, Hirschhorn J.N., Gordin, D., Samy Hadjadj (91107), Gu T., Zerbini Gianpaolo, Sandholm, N., Sandholm N., Groop, P.H., McKnight A.J., Guiducci, C., Lithovius R., Swan, Elizabeth J., Saraheimo M., S Mohsen Hosseini, EDIC Research Group, DCCT/, Cristian Serafinceanu (135168), Florez, J.C., Michel Marre (91106), Savage, David A., Sarti C., Parving, H.H., Nelson Robert G., Tikkanen H., Elizabeth J Swan, Serafinceanu, C., Thorn, Lena M, Ioana M., Tarnow Lise, Mota, Eugen, Tikkanen, Heikki Olavi, Salem Rany M., Williams, Winfred W, Soderlund, J., Brismar K., Marre M., Karl Tryggvason (135087), Helen M. Colhoun (130220), François Alhenc-Gelas, Hanson R.L., Savage David A., Stephen C. Bain (135204), Candace Guiducci, Boright A.P., Andrew P. Boright (135000), Godson C., Groop, Per Henrik, Brismar, K., Niina Sandholm, Kytö J., Marre, Michel, Tregouet, D.A., Parkkonen M., Marre, M., Denise M. Sadlier (134987), Pitkäniemi Janne, Amy Jayne McKnight, Kerstin Brismar, Shelley B. Bull (135189), Falhammar, Henrik, Soro-Paavonen A., Brennan Eoin P., Waden, J., Palmer Cameron, Savage, David A, Maestroni, Anna, Janne Kytö, Maestroni, A., Geoffrey V Gill, Vincent Rigalleau (135135), Martin F., Brennan, Eoin P., Brismar Kerstin, Taylor, A., Colhoun H.M., Panduru N.M., Geoffrey V. Gill (135099), Ioana, Mihai, Mota Maria, Silvia Maestroni (135145), Williams Winfred W., Hirschhorn, J.N., Lefebvre Pierre, Michel Marre, Nelson, R.G., Palmer, Cameron Douglas, Palmer, Cameron D., Janne Pitkäniemi (28917), McKay G.J., Keller B.J., Taylor A., Ioana, M., Winfred W Williams, Falhammar H., Shelley B Bull, Outi Heikkilä (135037), Ladenvall, C., Gordin, Daniel, Mihai Ioana, Paterson Andrew D., Isakova, Tamara, Andrew Taylor (135110), Sarah Prior (135104), Bull, Shelley B., Colhoun Helen M., Monica Stavarachi (135172), Sarti Cinzia, Johan Wadén, Stephen C Bain, Mollsten, A., McKay, G., Mota Eugen, Lajer Maria, Lajer, Maria, Hanson Robert L., Thorn, Lena M., Benjamin J Keller, Anne-May Österholm (135054), Gu, T., Colhoun, Helen M., Cimponeriu D., David A. Savage (135199), Lajer, M., Falhammar, H., He Bing, Emma Ahlqvist, Lise Tarnow, Janne Kytö (135043), Dahlström, Emma Helena, Colhoun, H.M., Finian Martin (135209), Ioana Mihai, Serafinceanu, Cristian, Mirel D.B., Huateng Huang, Anna Möllsten, Swan Elizabeth J., Maestroni Anna, Huang, Huateng, Roussel, R., Hirschhorn, Joel N., Panduru, N.M., Samy Hadjadj, Mota E., Roussel, Ronan, Thorn L.M., Matthias Kretzler, Thorn, Lena, Finian Martin, Godson Catherine, Nina Tolonen (135081), Keller Benjamin J., Jenny Söderlund (135069), Nicolae Mircea Panduru (135181), Harvest F. Gu (135183), Alhenc-Gelas François, Sandholm Niina, Gu, H.F., Rany M Salem, Valma Harjutsalo, Florez, Jose C., Tikkanen, Heikki, Jose C Florez, He, B., Maria Lajer, Brennan E.P., Robert G Nelson, Stavarachi, M., Huang Huateng, Gordin, Ted Daniel, Daniel B. Mirel (110265), Gu Harvest F., Österholm, Anne May, Tryggvason, Karl, Tianwei Gu, Mota, M., Markku Lehto, Brennan, Eoin P, Söderlund, Jenny, Kretzler, Matthias, Mäkinen V.-P., Huateng Huang (135018), Parkkonen Maija, Boright, A., Tamara Isakova (134971), Waggott D., Leif Groop, Maestroni A., Forsblom Carol, Hadjadj, Samy, Groop, Leif, Paterson, A.D., Anna Maestroni, Daniel Gordin (135027), Gareth J. McKay (134975), Parving Hans-Henrik, Ladenvall, Claes,, Tuomilehto Jaakko, Cimponeriu, D., Waggott Daryl, Tuomilehto, Jaakko, Markku Saraheimo (135067), Sadlier, DM, McKnight, AJ, Williams, WW, Brennan, EP, Forsblom, C, Sandholm, N, Makinen, V-P, Salem, RM, McKay, GJ, Isakova, T   +596 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Multiple Sclerosis Genomic Map implicates peripheral immune cells & microglia in susceptibility

Science, 2019
Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International ...
Nikolas A. Patsopoulos, Nikolas A. Patsopoulos, S. Baranzini, A. Santaniello, P. Shoostari, C. Cotsapas, G. Wong, Ashley H. Beecham, T. James, J. Replogle, I. Vlachos, C. McCabe, T. Pers, T. Pers, A. Brandes, Charles White, B. Keenan, M. Cimpean, P. Winn, Ioannis-Pavlos Panteliadis, A. Robbins, T. Andlauer, O. Zarzycki, B. Dubois, A. Goris, H. B. Søndergaard, F. Sellebjerg, P. Sørensen, H. Ullum, L. Thørner, J. Saarela, I. Cournu-Rebeix, V. Damotte, B. Fontaine, L. Guillot-Noel, M. Lathrop, S. Vukusic, A. Berthele, Viola Pongratz, C. Gasperi, C. Graetz, V. Grummel, B. Hemmer, Muni Hoshi, B. Knier, T. Korn, C. Lill, F. Luessi, M. Muehlau, F. Zipp, E. Dardiotis, C. Agliardi, A. Amoroso, N. Barizzone, M. Benedetti, L. Bernardinelli, P. Cavalla, F. Clarelli, G. Comi, D. Cusi, F. Esposito, L. Ferrè, D. Galimberti, C. Guaschino, M. Leone, V. Martinelli, L. Moiola, M. Salvetti, M. Sorosina, D. Vecchio, A. Zauli, S. Santoro, N. Mancini, M. Zuccalà, J. Mescheriakova, C. M. van Duijn, S. Bos, E. Celius, A. Spurkland, M. Comabella, X. Montalban, L. Alfredsson, I. Bomfim, D. Gómez-Cabrero, J. Hillert, M. Jagodic, M. Lindén, F. Piehl, I. Jelcic, Roland Martin, M. Sospedra, A. Baker, M. Ban, C. Hawkins, P. Hysi, S. Kalra, F. Karpe, J. Khadake, G. Lachance, P. Molyneux, M. Neville, J. Thorpe, E. Bradshaw, S. Caillier, P. Calabresi, B. Cree, A. Cross, M. Davis, P. D. de Bakker, S. Delgado, Marieme Dembele, K. Edwards, K. Fitzgerald, I. Frohlich, P. Gourraud, J. Haines, H. Hakonarson, D. Kimbrough, N. Isobe, I. Konidari, E. Lathi, Michelle H. Lee, Tai-an Li, D. An, A. Zimmer, L. Madireddy, C. Manrique, M. Mitrovic, M. Olah, E. Patrick, M. Pericak-Vance, L. Piccio, C. Schaefer, H. Weiner, K. Lage, R. Scott, J. Lechner-Scott, R. Leal, P. Moscato, David R. Booth, Graeme J. Stewart, S. Vucic, Grant Pame, Michael BamettO, D. Mason, L. Griffiths, S. Broadley, L. Tajouri, A. Baxter, M. Slee, B. Taylor, J. Charlesworth, T. Kilpatrick, J. Rubio, V. Jokubaitis, J. Wiley, H. Butzkueven, S. Leslie, A. Motyer, J. Stankovich, W. Carroll, A. Kermode, Marzena Edrin, M. Barclay, L. Peyrin-Biroulet, M. Chamaillard, J. Colombe, M. Cottone, A. Croft, R. D'Incà, J. Halfvarson, K. Hanigan, P. Henderson, J. Hugot, A. Karban, N. Kennedy, M. Khan, M. Lémann, A. Levine, D. Massey, M. Milla, Grant W. Motoey, S. Ng, Joannis Oikonomnou, H. Peeters, D. Proctor, J. Rahier, R. Roberts, P. Rutgeerts, F. Seibold, L. Stronati, K. Taylor, L. Törkvist, Kullak Ublick, J. van Limbergen, A. Van Gossum, M. Vatn, Hu Zhang, Wei Zhang, P. Donnelly, I. Barroso, Jenefer M. Blackwe, E. Bramon, Matthew A. Brown, J. Casas, A. Corvin, P. Deloukas, A. Duncanson, Janusz Jankowski, H. Markus, C. Mathew, C. Palmer, R. Plomin, A. Rautanen, Stephen Sawcer, R. Trembath, A. Viswanathan, N. Wood, C. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Zhan Sul, Damjan Vukcevic, C. Langford, S. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S. Bumpstead, S. Dronov, M. Gillman, E. Gray, N. Hammond, A. Jayakumar, O. Mccann, J. Liddle, S. Potter, R. Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, A. Compston, D. Hafler, H. Harbo, S. Hauser, G. Stewart, S. D'Alfonso, G. Hadjigeorgiou, Bruce E. Taylor, L. Barcellos, David Booth, R. Hintzen, I. Kockum, F. Martinelli-Boneschi, J. McCauley, J. Oksenberg, A. Oturai, S. Sawcer, A. Ivinson, T. Olsson, P. De Jager   +268 more
semanticscholar   +1 more source

Loss of susceptibility as a novel breeding strategy for durable and broad-spectrum resistance [PDF]

, 2010
Recent studies on plant immunity have suggested that a pathogen should suppress induced plant defense in order to infect a plant species, which otherwise would have been a nonhost to the pathogen. For this purpose, pathogens exploit effector molecules to
Visser, R.G.F., JACOBSEN E, VISSER RGF, Jacobsen, E., Pavan, S.N.C., Bai, Y., BAI Y., PAVAN, STEFANO   +7 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2 negative patients with early onset breast cancer

Genetics in Medicine, 2014
Purpose:Clinical testing for germ-line variation in multiple cancer susceptibility genes is available using massively parallel sequencing. Limited information is available for pretest genetic counseling regarding the spectrum of mutations and variants of
Kara N. Maxwell, B. Wubbenhorst, K. D'Andrea, Bradley Garman, Jessica M. Long, J. Powers, Katherine Rathbun, J. Stopfer, Jiajun Zhu, A. Bradbury, M. Simon, A. DeMichele, S. Domchek, K. Nathanson   +13 more
semanticscholar   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source