Results 11 to 20 of about 583,132 (315)

Susceptibility genes for complex epilepsy [PDF]

Human Molecular Genetics, 2005
Common idiopathic epilepsies are, clinically and genetically, a heterogeneous group of complex seizure disorders. Seizures arise from periodic neuronal hyperexcitability of unknown cause. The genetic component is mostly polygenic, where each susceptibility gene in any given individual is likely to represent a small component of the total heritability ...
Mulley, J., Scheffer, I., Harkin, L., Berkovic, S., Dibbens, L.   +4 more
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Susceptibility Genes in Thyroid Autoimmunity [PDF]

Journal of Immunology Research, 2005
The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the autoimmune response to thyroid antigens.
Yoshiyuki Ban, Yaron Tomer
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Genomic Analysis Highlights Putative Defective Susceptibility Genes in Tomato Germplasm

Plants, 2023
Tomato (Solanum lycopersicum L.) is one of the most widely grown vegetables in the world and is impacted by many diseases which cause yield reduction or even crop failure.
Ruiling Li, Alex Maioli, Sergio Lanteri, Andrea Moglia, Yuling Bai, Alberto Acquadro   +5 more
doaj   +1 more source

Gene–gene interactions in breast cancer susceptibility [PDF]

Human Molecular Genetics, 2011
There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 ...
Turnbull C, Seal S, Renwick A, Warren-Perry M, Hughes D, Elliott A, Pernet D, Peock S, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Ahmed M, Eccles D, Evans DG, Donnelly P, Easton DF, Stratton MR, Rahman N, Breast Canc Susceptibility, EMBRACE   +39 more
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Improving Pathogen Resistance by Exploiting Plant Susceptibility Genes in Coffee (Coffea spp.)

Agronomy, 2020
Coffee (Coffea spp.) is an economically important crop widely cultivated in (sub) tropical countries worldwide. Commercial coffee production relies mainly on two related species, namely C. arabica and C. canephora.
Lei Cui, Katharina Hanika, Richard G. F. Visser, Yuling Bai   +3 more
doaj   +1 more source

Susceptibility Is New Resistance: Wheat Susceptibility Genes and Exploitation in Resistance Breeding

Agriculture, 2022
Adapted pathogens and pests seriously threaten global wheat production. During pathogen and pest infections, wheat susceptibility (S) genes are exploited to support the compatibility of wheat with pathogens and pests.
Mengmeng Li, Zige Yang, Cheng Chang
doaj   +1 more source

A gene for susceptibility to tuberculosis [PDF]

Canadian Medical Association Journal, 2005
The complex genetic nature of what makes some people more susceptible than others to tuberculosis (TB) may finally be revealing itself. The answer may lie in the genes that control cell-mediated immunity specifically a newly discovered gene that governs how macrophages cope with infectious organisms such as Mycobacterium tuberculosis.
openaire   +2 more sources

IRGM variants and susceptibility to inflammatory bowel disease in the German population. [PDF]

, 2013
Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD susceptibility ...
Darina Czamara, Seiderer, J., Goke, B., Eleni Tsekeri (276693), Stephanie Bues, Fries, C., Julia Seiderer (107820), Beigel, F., Glas, J., Friedrich, Matthias, Christian Steib (174731), Czamara, D., Jürgen Glas (107816), Stephanie Bues (276692), Bues, S., Eleni Tsekeri, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Florian Beigel (174724), Beigel, Florian, Matthias Friedrich (174721), Stallhofer, J., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Steib, Christian, Göke, Burkhard, Fries, Christoph, Friedrich, M., Seiderer, Julia, Glas, Jürgen, Tsekeri, E., Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Martin Wetzke, Burkhard Göke, Christian Steib, Stephan Brand, Tsekeri, Eleni, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Julia Diegelmann (107830), Bues, Stephanie, Jürgen Glas, Wetzke, Martin, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten   +59 more
core   +1 more source

Genetic Susceptibility of the Host in Virus-Induced Diabetes

Microorganisms, 2020
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID).
Keiichiro Mine, Yasunobu Yoshikai, Hirokazu Takahashi, Hitoe Mori, Keizo Anzai, Seiho Nagafuchi   +5 more
doaj   +1 more source

Is COMT a Susceptibility Gene for Schizophrenia? [PDF]

Schizophrenia Bulletin, 2007
Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to psychiatry, these include dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other genes) in a fragment of chromosome 22q11 which when deleted results in a complex syndrome ...
Hywel J, Williams, Michael J, Owen, Michael C, O'Donovan   +2 more
openaire   +2 more sources