Results 41 to 50 of about 4,523 (159)

Identifying causal genes for migraine by integrating the proteome and transcriptome

The Journal of Headache and Pain, 2023
Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu, Jun Wu, Shi-lei Sun, Yong-gang Wang, Chang-he Shi   +19 more
doaj   +1 more source

Embracing polygenicity: a review of methods and tools for psychiatric genetics research. [PDF]

, 2017
The availability of genome-wide genetic data on hundreds of thousands of people has led to an equally rapid growth in methodologies available to analyse these data.
Maier, R.M., Robinson, M.R., Visscher, P.M., Wray, N.R.   +3 more
core   +2 more sources

Gene-based association tests using GWAS summary statistics and incorporating eQTL [PDF]

, 2022
Although genome-wide association studies (GWAS) have been successfully applied to a variety of complex diseases and identified many genetic variants underlying complex diseases via single marker tests, there is still a considerable heritability of ...
Cao, Xuewei, Sha, Qiuying, Wang, Xuexia, Zhang, Shuanglin   +3 more
core   +2 more sources

Delineating the Genetic Component of Gene Expression in Major Depression [PDF]

, 2020
Background: Major depression (MD) is determined by a multitude of factors including genetic risk variants that regulate gene expression. We examined the genetic component of gene expression in MD by performing a transcriptome-wide association study (TWAS)
Dall'Aglio, L. (Lorenza), Lewis, C.M. (Cathryn), Pain, O. (Oliver)   +2 more
core   +1 more source

Heritability enrichment of immunoglobulin G N-glycosylation in specific tissues [PDF]

, 2021
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Cao, Weijie, Guo, Xiuhua, Han, Jingdong J, Hou, Haifeng, Lang, Minglin, Li, Xingang, Manshu, Song, Tan, Xuerui, Wang, Hao, Wang, Wei, Wang, Youxin, Zhu, Yahong   +11 more
core   +2 more sources

Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses

Frontiers in Genetics, 2022
Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu, Ruoyang Feng, Yuesheng Liu, Yujie Qin, Hongyang Deng, Yanfeng Xiao, Chunyan Yin   +6 more
doaj   +1 more source

Transcriptome-wide association study reveals candidate causal genes for lung cancer. [PDF]

, 2023
We have recently completed the largest GWAS on lung cancer including 29,266 cases and 56,450 controls of European descent. The goal of our study has been to integrate the complete GWAS results with a large-scale expression quantitative trait loci (eQTL ...
Albanes, D, Aldrich, MC, Amos, CI, Andrew, A, Arnold, S, Bickeböller, H, Bojesen, SE, Bossé, Y, Brennan, P, Brunnstrom, H, Caporaso, N, Carreras-Torres, R, Chen, C, Christiani, DC, Field, JK, Gabriel, A, Gaudreault, N, Goodman, G, Grankvist, K, Houlston, R, Hung, RJ, Johansson, M, Johansson, M, Joubert, P, Kiemeney, LA, Lam, S, Landi, MT, Lazarus, P, Le Marchand, L, Li, Z, Liu, G, Manem, V, McKay, JD, Melander, O, Obeidat, M, Rennert, G, Risch, A, Rosenberg, SM, Schabath, MB, Shete, S, Song, Z, Stevens, VL, Tardon, A, Timens, W, Wichmann, H-E, Woll, P, Xia, J, Zienolddiny, S   +47 more
core   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

A transcriptome-wide association study of Alzheimer’s disease using prediction models of relevant tissues identifies novel candidate susceptibility genes [PDF]

, 2021
: Background: Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown.

core   +3 more sources

Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome

Communications Biology, 2022
Calwing Liao and Veikko Vuokila et al. report a transcriptome-wide association study (TWAS) of Tourette’s Syndrome. They find increased expression of FLT3 in the dorsolateral prefrontal cortex and the lymphoblastoid cell lines in patients with Tourette’s
Calwing Liao, Veikko Vuokila, Hélène Catoire, Fulya Akçimen, Jay P. Ross, Cynthia V. Bourassa, Patrick A. Dion, Inge A. Meijer, Guy A. Rouleau   +8 more
doaj   +1 more source