Results 41 to 50 of about 41,900,780 (178)

Transcriptome-wide association study: Opportunity and challenges for cancer studies

, 2022
Genome-wide association studies (GWAS) have uncovered thousands of single nucleotide polymorphism (SNP) loci that are associated with complex traits.
Kendy Shang, Jingni He*
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From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
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Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma

Nature Communications, 2018
Genetic loci linked to susceptibility for the common skin cancer cutaneous squamous cell carcinoma (cSCC) have been identified by genome wide association studies (GWAS).
Nilah M. Ioannidis, Wei Wang, Nicholas A. Furlotte, David A. Hinds, 23andMe Research Team, Carlos D. Bustamante, Eric Jorgenson, Maryam M. Asgari, Alice S. Whittemore   +8 more
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Transcriptome-wide association study reveals increased neuronal FLT3 expression is associated with Tourette’s syndrome

Communications Biology, 2022
Calwing Liao and Veikko Vuokila et al. report a transcriptome-wide association study (TWAS) of Tourette’s Syndrome. They find increased expression of FLT3 in the dorsolateral prefrontal cortex and the lymphoblastoid cell lines in patients with Tourette’s
Calwing Liao, Veikko Vuokila, Hélène Catoire, Fulya Akçimen, Jay P. Ross, Cynthia V. Bourassa, Patrick A. Dion, Inge A. Meijer, Guy A. Rouleau   +8 more
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Model checking via testing for direct effects in Mendelian Randomization and transcriptome-wide association studies

, 2021
This article proposes a new and general goodness-of-fit (GOF) test, called TEDE (TEsting Direct Effects), applicable to both correlated and independent SNPs/IVs as commonly used in transcriptome-wide association studies (TWAS) and Mendelian ...
Pan, Wei, Deng, Yangqing, Wei Pan, Yangqing Deng   +3 more
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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Nature Communications, 2018
Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to ...
Nicholas Mancuso, Simon Gayther, Alexander Gusev, Wei Zheng, Kathryn L. Penney, Zsofia Kote-Jarai, Rosalind Eeles, Matthew Freedman, Christopher Haiman, Bogdan Pasaniuc, The PRACTICAL consortium   +10 more
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A cross-tissue transcriptome association study identifies key genes in essential hypertension

Frontiers in Genetics, 2023
Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative
Sihui Huang, Sihui Huang, Sihui Huang, Jie Wang, Jie Wang, Nannan Liu, Nannan Liu, Ping Li, Ping Li, Sha Wu, Sha Wu, Luming Qi, Luming Qi, Lina Xia, Lina Xia   +14 more
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Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

, 2020
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations ...
A Cox (65204), SS Cross (65203), PA Ganz (7690508), MM Gaudet (16151798), D Campa (14595551), S Canisius (16225106), M Dwek (14595569), I Campbell (9858182), A Broeks (16225265), Irene L. Andrulis (7249589), M Bermisheva (14595536), M García-Closas (14595590), DE Goldgar (15963959), J Carter (7734920), F Fostira (21329390), C Engel (7690352), Jirong Long (181371), Adalgeir Arason (238680), A Borg (14579681), CL Clarke (14595563), BD Carter (21283268), Daniel R. Barnes (21302132), S Behrens (9849644), I Briceno (16309332), AM Dunning (7665791), NV Bogdanova (14595542), SE Bojesen (7708931), A Blanco (15461204), Q Cai (7738784), MW Beckmann (14595533), B Boeckx (7748954), E Friedman (7720619), Alexander Gusev (303262), CA Haiman (14595605), Helian Feng (6682787), L Fritschi (13290768), D Frost (7690298), SJ Chanock (7675700), WK Chung (14471805), Antonis C. Antoniou (8116067), H Brenner (7672451), KBM Claes (21302348), M Eriksson (14595578), PA Fasching (14320293), GG Giles (10582850), Kristan J. Aronson (6169946), MB Daly (7690637), T Caldés (21329381), K Czene (14560481), B Ejlertsen (7690202), G Glendon (7690568), Daniel Barrowdale (395192), Volker Arndt (146500), Banu K. Arun (8115974), P Guénel (14595596), C Ellberg (21283277), Lang Wu (540806), O Fletcher (10941414), Bogdan Pasaniuc (120790), JE Castelao (14595557), MH Greene (7690556), B Bonanni (7690238), Paul L. Auer (3987392), J Chang-Claude (7665785), C Blomqvist (14595539), K De Leeneer (21329387), Hoda Anton-Culver (3473), MS Goldberg (11403186), A González-Neira (16225412), H Christiansen (16225349), J Garber (16225832), J Gronwald (13408320), Judith Balmaña (395210), MA Caligo (7690589), JA García-Sáenz (14595593), Rosa B. Barkardottir (11731332), DM Eccles (14595572), T Brüning (13614535), M de la Hoya (7690454), Zomoroda Abu-full (21329384), C Cybulski (16097036), M Gabrielson (14595584), Rodney Scott (21131678), H Flyger (14595581), J Benitez (13666594), SM Domchek (7690163), B Burwinkel (16166039), Ella Asseryanis (5509292), T Dörk (13408197), K Bialkowska (21329378), Jacopo Azzollini (3749725), Kristiina Aittomäki (89889), SM Gapstur (15807293), J Dennis (7837124), P Devilee (13751182), MK Bolla (14595506), AK Godwin (7690349), H Brauch (13751221), I dos-Santos-Silva (16225862), FJ Couch (7690157), O Diez (21302351)   +100 more
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Transcriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety

Frontiers in Genetics, 2021
Anxiety disorders are common mental disorders that often result in disability. Recently, large-scale genome-wide association studies (GWASs) have identified several novel risk variants and loci for anxiety disorders (or anxiety traits). Nevertheless, how
Xi Su, Xi Su, Wenqiang Li, Wenqiang Li, Luxian Lv, Luxian Lv, Xiaoyan Li, Jinfeng Yang, Jinfeng Yang, Xiong-Jian Luo, Xiong-Jian Luo, Xiong-Jian Luo, Xiong-Jian Luo, Jiewei Liu   +13 more
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Transcriptome-wide association and prediction for carotenoids and tocochromanols in fresh sweet corn kernels

, 2021
Sweet corn is consistently one of the most highly consumed vegetables in the U.S., providing a valuable opportunity to increase nutrient intake through biofortification.
University of Georgia (17856095)
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