Results 41 to 50 of about 39,970,022 (174)

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source

TWAS revealed significant causal loci for milk production and its composition in Murrah buffaloes

Scientific Reports, 2023
Milk yield is the most complex trait in dairy animals, and mapping all causal variants even with smallest effect sizes has been difficult with the genome-wide association study (GWAS) sample sizes available in geographical regions with small livestock ...
Supriya Chhotaray, Vikas Vohra, Vishakha Uttam, Ameya Santhosh, Punjika Saxena, Rajesh Kumar Gahlyan, Gopal Gowane   +6 more
doaj   +1 more source

Identifying causal genes for migraine by integrating the proteome and transcriptome

The Journal of Headache and Pain, 2023
Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these variants contribute to the development of migraine.
Shuang-jie Li, Jing-jing Shi, Cheng-yuan Mao, Chan Zhang, Ya-fang Xu, Yu Fan, Zheng-wei Hu, Wen-kai Yu, Xiao-yan Hao, Meng-jie Li, Jia-di Li, Dong-rui Ma, Meng-nan Guo, Chun-yan Zuo, Yuan-yuan Liang, Yu-ming Xu, Jun Wu, Shi-lei Sun, Yong-gang Wang, Chang-he Shi   +19 more
doaj   +1 more source

DataSheet1_A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk.DOCX

, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression.
John C. Cheville (10954118), Liang Wang (23021), Amy J. French (12320228), Stephen N. Thibodeau (9335481), Yuanhang Liu (547018), Lori S. Tillmans (6565040), Nicholas B. Larson (4691740), Daniel J. Schaid (3716326), Zachary Fogarty (12320225), Shannon K. McDonnell (12320222)   +9 more
core   +1 more source

Table2_A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk.XLSX

, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression.
John C. Cheville (10954118), Liang Wang (23021), Amy J. French (12320228), Stephen N. Thibodeau (9335481), Yuanhang Liu (547018), Lori S. Tillmans (6565040), Nicholas B. Larson (4691740), Daniel J. Schaid (3716326), Zachary Fogarty (12320225), Shannon K. McDonnell (12320222)   +9 more
core   +1 more source

Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses

Frontiers in Genetics, 2022
Celiac disease (CeD) is one of the most common intestinal inflammatory diseases, and its incidence and prevalence have increased over time. CeD affects multiple organs and systems in the body, and environmental factors play a key role in its complex ...
Mengnan Lu, Ruoyang Feng, Yuesheng Liu, Yujie Qin, Hongyang Deng, Yanfeng Xiao, Chunyan Yin   +6 more
doaj   +1 more source

Table1_A microRNA Transcriptome-wide Association Study of Prostate Cancer Risk.XLSX

, 2022
Large genome-wide association studies have identified hundreds of single-nucleotide polymorphisms associated with increased risk of prostate cancer (PrCa), and many of these risk loci is presumed to confer regulatory effects on gene expression.
John C. Cheville (10954118), Liang Wang (23021), Amy J. French (12320228), Stephen N. Thibodeau (9335481), Yuanhang Liu (547018), Lori S. Tillmans (6565040), Nicholas B. Larson (4691740), Daniel J. Schaid (3716326), Zachary Fogarty (12320225), Shannon K. McDonnell (12320222)   +9 more
core   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction

Frontiers in Genetics, 2021
BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen, Guanzhong Chen, Liwei Liu, Liwei Liu, Huanqiang Li, Zhubin Lun, Zhubin Lun, Ziling Mai, Ziling Mai, Wenguang Lai, Wenguang Lai, Enzhao Chen, Chunyun Zhou, Sijia Yu, Sijia Yu, Junqing Yang, Shiqun Chen, Jiyan Chen, Jiyan Chen, Jiyan Chen, Yong Liu, Yong Liu, Yong Liu   +22 more
doaj   +1 more source

Cross-population Transcriptome Prediction Models for Transcriptome-Wide Association Studies in Diverse Populations

, 2022
Genome-wide association studies (GWAS) have been utilized to find associations between single nucleotide polymorphisms (SNPs) and traits. However, most GWAS are conducted on populations of European ancestries. Further analysis involving the transcriptome
Nguyen, Christopher, Wheeler, Dr. Heather, Araujo, Daniel   +2 more
core   +1 more source

From Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology

Xiehe Yixue Zazhi
Over the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...
FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan   +8 more
doaj   +1 more source