Results 51 to 60 of about 4,523 (159)
A cross-tissue transcriptome association study identifies key genes in essential hypertension
Frontiers in Genetics, 2023 Genome-wide association study (GWAS) have identified over 1,000 loci associated with blood pressure. However, these loci only explain 6% of heritability. Transcriptome-wide association studies (TWAS) combine GWAS summary data with expression quantitative Sihui Huang, Sihui Huang, Sihui Huang, Jie Wang, Jie Wang, Nannan Liu, Nannan Liu, Ping Li, Ping Li, Sha Wu, Sha Wu, Luming Qi, Luming Qi, Lina Xia, Lina Xia +14 moredoaj +1 more sourceFrom Gene Expression to Transcriptome-wide Association Study: Development and Comparison of Methodology
Xiehe Yixue ZazhiOver the past two decades, genome-wide association study(GWAS) has identified numerous genetic variants and loci associated with heritable diseases. With the gradual maturation and saturation of GWAS methodologies, transcriptome-wide association study ...FANG Kun, LI Guozhuang, WANG Linting, LI Qing, XU Kexin, ZHAO Lina, WU Zhihong, ZHANG Jianguo, WU Nan +8 moredoaj +1 more sourceTranscriptome-Wide Association Study Provides Insights Into the Genetic Component of Gene Expression in Anxiety
Frontiers in Genetics, 2021 Anxiety disorders are common mental disorders that often result in disability. Recently, large-scale genome-wide association studies (GWASs) have identified several novel risk variants and loci for anxiety disorders (or anxiety traits). Nevertheless, how Xi Su, Xi Su, Wenqiang Li, Wenqiang Li, Luxian Lv, Luxian Lv, Xiaoyan Li, Jinfeng Yang, Jinfeng Yang, Xiong-Jian Luo, Xiong-Jian Luo, Xiong-Jian Luo, Xiong-Jian Luo, Jiewei Liu +13 moredoaj +1 more sourceIntegrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions [PDF]
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 ...Aben, Katja KH, Anton-Culver, Hoda, Antonenkova, Natalia N, AOCS, Group, Aravantinos, Gerasimos, Bandera, Elisa V, Beane Freeman, Laura E, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Berchuck, Andrew, Bernardini, Marcus Q, Bjorge, Line, Black, Amanda, Bogdanova, Natalia V, Bolton, Kelly L, Brenton, James D, Budzilowska, Agnieszka, Butzow, Ralf, Cai, Hui, Campbell, Ian, Cannioto, Rikki, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Kexin, Chen, Stephanie, Chenevix-Trench, Georgia, Chiew, Yoke-Eng, Coetzee, Simon G, Cook, Linda S, Dareng, Eileen O, Davis, Brian D, DeFazio, Anna, Dennis, Joe, Dezem, Felipe Segato, Doherty, Jennifer A, du Bois, Andreas, Dörk, Thilo, Dürst, Matthias, Eccles, Diana M, Edwards, Digna Velez, Ene, Gabrielle, Fasching, Peter A, Flanagan, James M, Fortner, Renée T, Fostira, Florentia, Freedman, Matthew L, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Giles, Graham G, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Haiman, Christopher A, Hazelett, Dennis, Heitz, Florian, Hildebrandt, Michelle AT, Huang, Ruea-Yea, Huntsman, David G, Håkansson, Niclas, Høgdall, Claus K, Høgdall, Estrid, Jensen, Allan, Jones, Michael E, Jones, Michelle R, Kang, Daehee, Kar, Siddhartha, Karlan, Beth Y, Karnezis, Anthony N, Kelemen, Linda E, Kennedy, Catherine J, Khusnutdinova, Elza K, Kiemeney, Lambertus A, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Labrie, Marilyne, Lambrechts, Diether, Larson, Melissa C, Lawrenson, Kate, Le, Nhu D, Lester, Jenny, Li, Lian, Lubiński, Jan, Lush, Michael, Marks, Jeffrey R, Matsuo, Keitaro, May, Taymaa, McLaughlin, John R, McNeish, Iain A, Menon, Usha, Missmer, Stacey, Modugno, Francesmary, Moffitt, Melissa, Monteiro, Alvaro N, Moysich, Kirsten B, Nameki, Robbin, Narod, Steven A, Nguyen-Dumont, Tu, Odunsi, Kunle, Olsson, Håkan, Onland-Moret, N Charlotte, OPAL Study, Group, Ovarian Cancer Association Consortium, (OCAC), Park, Sue K, Pearce, Celeste L, Pejovic, Tanja, Peng, Pei-Chen, Permuth, Jennifer B, Pharoah, Paul DP, Piskorz, Anna, Plummer, Jasmine T, Prokofyeva, Darya, Ramus, Susan J, Reyes, Alberto L, Riggan, Marjorie J, Risch, Harvey A, Rodríguez-Antona, Cristina, Rosenow, Will, Rossing, Mary Anne, Sandler, Dale P, Schildkraut, Joellen M, Sellers, Thomas A, Seo, Ji-Heui, Setiawan, V Wendy, Shan, Kang, Song, Honglin, Southey, Melissa C, Steed, Helen, Sutphen, Rebecca, Swerdlow, Anthony J, Teo, Soo Hwang, Terry, Kathryn L, Thompson, Pamela J, Titus, Linda, Trabert, Britton, Travis, Ruth, Tworoger, Shelley S, Tyrer, Jonathan P, Valen, Ellen, Van Nieuwenhuysen, Els, Vestrheim Thomsen, Liv Cecilie, Vierkant, Robert A, Webb, Penelope M, Weinberg, Clarice R, Weise, Rayna Matsuno, Wentzensen, Nicolas, White, Emily, Winham, Stacey J, Wolk, Alicja, Woo, Yin-Ling, Wu, Anna H, Yan, Li, Yannoukakos, Drakoulis, Zeinomar, Nur, Zheng, Wei, Ziogas, Argyrios +155 morecore +4 more sourcesIdentification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis
Arthritis Research & Therapy, 2023 Background Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environmental factors.Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren, Zhihong Li +5 moredoaj +1 more sourceDivergent Paths: A Comprehensive Review of Mechanisms and Clinical Implications in Atopic Dermatitis and Psoriasis
Allergy, EarlyView.ABSTRACT
Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects Tali Czarnowicki, Kazunari Sugita, Zenas Yiu, Sandra Díez‐Ribas, Irene Garcia‐Jimenez, Emma Guttman‐Yassky, Luis F. Santamaria‐Babí +6 morewiley +1 more sourceTranscriptome-Wide Association Supplements Genome-Wide Association in Zea mays. [PDF]
, 2019 Modern improvement of complex traits in agricultural species relies on successful associations of heritable molecular variation with observable phenotypes. Historically, this pursuit has primarily been based on easily measurable genetic markers.Bandillo, Nonoy B, Buckler, Edward S, Diepenbrock, Christine H, Gore, Michael A, Kremling, Karl AG +4 morecore +1 more sourceOverview on the Role of Advance Genomics in Conservation Biology of Endangered Species [PDF]
, 2016 In the recent era, due to tremendous advancement in industrialization, pollution and other anthropogenic activities have created a serious scenario for biota survival.Hou, Hongwei, Khan, Suliman, Manan, Sehrish, Nabi, Ghulam, Siddique, Rabeea, Ullah, Muhammad Wajid, Yousaf, Muhammad +6 morecore +2 more sourcesTranscriptome- and Proteome-Wide Association Studies Nominate Determinants of Kidney Function and Damage [PDF]
, 2023 BACKGROUND: The pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic, transcriptomic, and proteomic association studies can nominate causal determinants of kidney function and ...Arking, Dan E, Boerwinkle, Eric, Chatterjee, Nilanjan, Coresh, Josef, Grams, Morgan E, Liu, Hongbo, Rhee, Eugene P, Schlosser, Pascal, Surapaneni, Aditya L, Susztak, Katalin, Welling, Paul A, Yu, Bing, Zhang, Jingning +12 morecore +2 more sources
