Results 61 to 70 of about 41,900,780 (178)

Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles

Arthritis Research & Therapy, 2023
Aim Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood, with genetic susceptibility and pathological processes such as autoimmunity and autoinflammation, but its pathogenesis is unclear.
Ruoyang Feng, Mengnan Lu, Chunyan Yin, Ke Xu, Lin Liu, Peng Xu   +5 more
doaj   +1 more source

Integrating genome‐ and transcriptome‐wide association studies to uncover the host–microbiome interactions in bovine rumen methanogenesis

iMeta
The ruminal microbiota generates biogenic methane in ruminants. However, the role of host genetics in modifying ruminal microbiota‐mediated methane emissions remains mysterious, which has severely hindered the emission control of this notorious ...
Wei Wang, Zhenyu Wei, Zhuohui Li, Jianrong Ren, Yanliang Song, Jingyi Xu, Anguo Liu, Xinmei Li, Manman Li, Huimei Fan, Liangliang Jin, Zhannur Niyazbekova, Wen Wang, Yuanpeng Gao, Yu Jiang, Junhu Yao, Fuyong Li, Shengru Wu, Yu Wang   +18 more
doaj   +1 more source

Integrative analysis of transcriptome-wide association study and gene expression profiling identifies candidate genes associated with stroke [PDF]

PeerJ, 2019
Background Stroke is a major public health burden worldwide. Although genetic variation is known to play a role in the pathogenesis of stroke, the specific pathogenic mechanisms are still unclear.
Jian Yang, Bin Yan, Yajuan Fan, Lihong Yang, Binbin Zhao, Xiaoyan He, Qingyan Ma, Wei Wang, Ling Bai, Feng Zhang, Xiancang Ma   +10 more
doaj   +2 more sources

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9518-9534, October 2026.
ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic ...
Ping He, Mingxiu Wang, Hang Mei, Yue Liu, Min Wang, He Sun, Yali Peng, Xuan Ban, Yue Wang, Xiaofang Tang, Qiuling Fan   +10 more
wiley   +1 more source

Genome‐Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID‐19

Influenza and Other Respiratory Viruses, Volume 20, Issue 10, October 2026.
ABSTRACT Background Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although previous studies have explored genetic susceptibility to influenza infection, the genetic basis of influenza hospitalization and its relationship with respiratory diseases like COVID‐19 remain poorly understood ...
Xiao Xue, Yaning Feng, Yu‐Ping Lin, Pui‐Ching Chan, Hon‐Cheong So   +4 more
wiley   +1 more source

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome.
Shuyi Guo, Jingjing Yang
doaj   +1 more source

The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1816-1834, October 2026.
Using Mendelian randomization, TWAS/eQTL analysis, machine learning, and single‐cell RNA sequencing, this study identified gut microbiota taxa causally linked to type 2 diabetes, candidate mediator genes, and diagnostic markers (BEND7, BLVRA, C1orf85, and LAMC1).
Yu‐yang Chen, Yi‐fan Shi, Xin‐yue Zhang, Jing‐yue Zhang, Shi‐mao Zhang, Heng‐xia Zhao, De‐liang Liu   +6 more
wiley   +1 more source

Power analysis of transcriptome-wide association study: Implications for practical protocol choice.

PLoS Genetics, 2021
The transcriptome-wide association study (TWAS) has emerged as one of several promising techniques for integrating multi-scale 'omics' data into traditional genome-wide association studies (GWAS).
Chen Cao, Bowei Ding, Qing Li, Devin Kwok, Jingjing Wu, Quan Long   +5 more
doaj   +1 more source

Problems With GO Enrichment as an Endpoint for Ecological Omics Interpretation

Molecular Ecology, Volume 35, Issue 19, October 2026.
ABSTRACT Gene Ontology (GO) enrichment analysis has been widely adopted for interpretating omics data, including in ecological research. Although valuable for summarizing large gene lists into functional categories, it is often treated as the final interpretive step.
Ehsan Pashay Ahi, Nidal Karagic, Spiros Papakostas   +2 more
wiley   +1 more source

A Genome‐Wide Meta‐Analysis of Functional Dyspepsia in 1,168,899 Individuals Implicates Immune Pathways in Disease Susceptibility

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
Our findings indicate that genetic variants in immune‐related genes (HLA‐DQB1 and DHX36) may influence functional dyspepsia risk by modulating gastrointestinal inflammatory responses, reinforcing the role of an immune‐mediated component in disease susceptibility and nominating these genes for further mechanistic investigation.
Cristian Díaz‐Muñoz, Bert Broeders, Ferdinando Bonfiglio, Andreea Zamfir‐Taranu, Joris Arts, Peter Banovcin, Luis Bujanda, Vasile Drug, Dan Dumitrascu, Guillaume Gourcerol, Sébastien Kindt, Peter Lipták, Chloé Melchior, Carolina Malagelada, Edoardo Vincenzo Savarino, Artemis Trikola, Jara Lehoucq, Florencia Carbone, Jan Tack, Mauro D'Amato   +19 more
wiley   +1 more source