Results 81 to 90 of about 4,523 (159)

Genetic risk factor identification for common epilepsies guided by integrative omics data analysis

Epilepsia, Volume 67, Issue 3, Page 1406-1420, March 2026.
Abstract Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are ...
Ashwini Mushunuri, Oluyomi Adesoji, Roland Krause, Patrick May, Holger Lerche, Albert Becker, Daniela Grimm, International League Against Epilepsy Consortium on Complex Epilepsies, Michael Nothnagel, Herbert Schulz   +9 more
wiley   +1 more source

Analyses of plasma multi‐omic data across ancestries identify novel pathways implicated in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Few genetic studies on Alzheimer's disease (AD) have incorporated multiple ancestries and omic datasets to pinpoint actionable AD risk effectors for each ancestry. METHODS Here, we first performed genetic colocalization between molecular phenotypes (proteomics and metabolomics) from two ancestral groups (European [EUR] and African
Chengran Yang, Jigyasha Timsina, Menghan Liu, John Budde, Pat Kohlfeld, William Brock, John C. Morris, David M. Holtzman, Yun Ju Sung, Carlos Cruchaga   +9 more
wiley   +1 more source

Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults.

PLoS Genetics, 2021
As a type of relatively new methodology, the transcriptome-wide association study (TWAS) has gained interest due to capacity for gene-level association testing.
Binglan Li, Yogasudha Veturi, Anurag Verma, Yuki Bradford, Eric S Daar, Roy M Gulick, Sharon A Riddler, Gregory K Robbins, Jeffrey L Lennox, David W Haas, Marylyn D Ritchie   +10 more
doaj   +1 more source

High‐Throughput Screen of NPQ in Sorghum Shows Highly Polygenic Architecture of Photoprotection

Plant-Environment Interactions, Volume 7, Issue 1, February 2026.
ABSTRACT Natural genetic variation in photosynthesis and photoprotection within crop germplasm represents an untapped resource for crop improvement. Sorghum bicolor (sorghum) is one of the world's most widely grown crops, yet the genetic basis of photoprotection in sorghum is not well understood.
Richard L. Vath, Samuel B. Fernandes, Brandon Monier, Katarzyna Głowacka, Julia Walter, Alexander E. Lipka, John Ferguson, Carl J. Bernacchi, Taylor Pederson, Johannes Kromdijk   +9 more
wiley   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 84-88, January 2026.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Using Genome and Transcriptome Data From African-Ancestry Female Participants To Identify Putative Breast Cancer Susceptibility Genes [PDF]

African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susceptibility genes.
Adejumo, Prisca O, Ahearn, Thomas, Ambrosone, Christine, Ambs, Stefan, Barnard, Mollie E, Brewster, Abenaa M, Butler, Ebonee N, Cai, Qiuyin, Chen, Yu, Garcia-Closas, Montserrat, Gu, Jian, Guo, Xingyi, Haiman, Christopher A, Hennis, Anselm J M, Hu, Jennifer J, Huang, Maosheng, Huo, Dezheng, Jia, Guochong, John, Esther M, Li, Bingshan, Li, Christopher I, Long, Jirong, Makumbi, Timothy, Nathanson, Katherine, Ndom, Paul, Nemesure, Barbara, Ntekim, Atara, O\u27Brien, Katie M, Olopade, Olufunmilayo I, Olshan, Andrew F, Oluwasanu, Mojisola M, Pal, Tuya, Palmer, Julie R, Ping, Jie, Press, Michael F, Reid, Sonya, Sanderson, Maureen, Sandler, Dale P, Tao, Ran, Troester, Melissa A, Yao, Song, Yoshimatsu, Toshio, Zheng, Wei   +42 more
core   +5 more sources

Genomic Structural Equation Modeling Provides an Initial View of the Genetic Architecture Related to Type 1 Gaucher Disease

Human Mutation, Volume 2026, Issue 1, 2026.
The genetic architecture underlying traits associated with Type 1 Gaucher disease (GD1) remains insufficiently explored. We integrated genomic structural equation modeling and multiple post–genome‐wide association study (GWAS) methodologies to prioritize candidate SNPs associated with GD1‐related variation, identifying 15 loci with strong statistical ...
Shijie Ren, Mingmin Du, Jingyuan Liu, Boyu Li, Jianping Liu, Xiaomeng Lang, Shaoqiu Chen   +6 more
wiley   +1 more source

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework

Cell Genomics
Summary: Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data.
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar-Magaña, Sarah Sumner, Hyunki Kim, Saideep Gona, Festus Nyasimi, Rohit Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im   +13 more
doaj   +1 more source

Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub

Ecotoxicology and Environmental Safety
Air pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...
Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi   +10 more
doaj   +1 more source

Discovery of genomic and transcriptomic pleiotropy between kidney function and soluble receptor for advanced glycation end products using correlated meta-analyses:The Long Life Family Study [PDF]

Patients with chronic kidney disease (CKD) have increased oxidative stress and chronic inflammation, which may escalate the production of advanced glycation end-products (AGEs).
Acharya, Sandeep, Brent, Michael R., Christensen, Kaare, Feitosa, Mary F., Kuipers, Allison L., Kulminski, Alexander M, Lin, Shiow J., Province, Michael A., Thyagarajan, Bharat, Wojczynski, Mary K., Zmuda, Joseph M.   +10 more
core   +1 more source