Results 71 to 80 of about 2,884 (146)

APOE*4 risk‐modifying genes and drug targets in Alzheimer's disease through cell‐type‐specific genomic analyses

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Genetics studies can identify drug targets that counteract the effects of the apolipoprotein E ε4 allele (APOE*4) on Alzheimer's disease (AD) but have remained limited in power and crucially did not assess genetic findings with regard to APOE*4's cell‐type‐specific impact on pathobiology.
Youjie Zeng, Noah Cook, Chenyu Yang, Sathesh K. Sivasankaran, Masashi Fujita, Zachary A. Gardell, Yann Le Guen, Daichi Shigemizu, Kouichi Ozaki, Takashi Morizono, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Cyril Pottier, Carlos Cruchaga, Valerio Napolioni, M. Ryan Corces, Vilas Menon, Michael D. Greicius, Michael E. Belloy   +19 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Human multi‐tissue transcriptomics identifies galectin‐1 and follistatin‐like 1 as exerkines with distinct transcript‐to‐serum coupling after exercise

The Journal of Physiology, Volume 604, Issue 12, Page 4815-4833, 15 June 2026.
Abstract figure legend Acute aerobic exercise induces LGALS1, FSTL1, OGN and C1QTNF3 in both skeletal muscle and adipose tissue, with LGALS1 and FSTL1 upregulation corresponding to increased circulating galectin‐1 and follistain‐like 1. Red and yellow brick bars represent the contribution of skeletal muscle and adipose tissue, respectively, integrating
Jaeseung Song, Eun‐Suk Cho, Yu Rim Kwon, Jong Suk Park, Ji Sun Nam, YuSik Kim   +5 more
wiley   +1 more source

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework

Cell Genomics
Summary: Transcriptome-wide association studies (TWASs) help identify disease-causing genes but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity of cell-type-specific expression data.
Yichao Zhou, Temidayo Adeluwa, Lisha Zhu, Sofia Salazar-Magaña, Sarah Sumner, Hyunki Kim, Saideep Gona, Festus Nyasimi, Rohit Kulkarni, Joseph E. Powell, Ravi Madduri, Boxiang Liu, Mengjie Chen, Hae Kyung Im   +13 more
doaj   +1 more source

TWAS-CTL: A robust and efficient method for multi-tissue transcriptome-wide association studies using cross-tissue learners

Abstract The advent of transcriptome-wide association studies (TWAS) has expanded the classical genome-wide association study (GWAS) framework by integrating gene expression with genetic variation to identify trait-associated variants.
Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang   +3 more
openaire   +1 more source

Multi-omic characterization of air pollution effects: Applications of AirSigOmniTWP Hub

Ecotoxicology and Environmental Safety
Air pollution, particularly fine particulate matter and gaseous pollutants including NO2 and NOx, presents significant public health challenges. While the harmful effects of these pollutants are well-documented, the molecular mechanisms underlying their ...
Wei Liu, Tong Liu, Xinxin Si, Jiaxing Liang, Xia Yan, Juexin Zhang, Bing Pang, Wenmin Luo, Junhong Liu, Huazhe Yang, Peng Shi   +10 more
doaj   +1 more source

Genome-Wide Association Study Identifies Candidate Genes for Body Size Traits in Wanyue Black Pigs

Animals
This study aimed to elucidate the genetic basis of body-size-related traits in Wanyue Black pigs, including body length, chest circumference, forearm circumference, and hip circumference. Phenotypic data were collected from 139 four-month-old female pigs,
Haibo Ye, Wei Li, Fang Tian, Qianqian Wang, Zhonghua Ma, Jinyu Guan, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhang   +9 more
doaj   +1 more source

CTA-TWAS: Cell-type-aware Transcriptome-wide Association Studies

The analysis code used to produce all results for "Cell type aware Transcriptome Wide Association Studies Identify 91 Independent Risk Genes for Alzheimer’s Disease Dementia"
openaire   +1 more source

Transcriptome-wide association studies associated with Crohn’s disease: challenges and perspectives

Cell & Bioscience
Crohn’s disease (CD) is regarded as a lifelong progressive disease affecting all segments of the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) and gene expression data, transcriptome-wide association studies (TWAS)
Keyu Jia, Jun Shen
doaj   +1 more source

Endothelial Vasoactive Pathways and Renal Outcomes: A Drug-Target Mendelian Randomization and Transcriptome-Wide Association Study

Kidney Diseases
Introduction: Endothelium-mediated regulation of vascular tone plays a crucial role in modulating vascular functions, especially in the kidney, a highly vascularized organ.
Yixin Ma, Lubin Xu, Yitao Lin, Jiahao Zhu, Jin Liu, Li Wang, Limeng Chen   +6 more
doaj   +1 more source