Results 71 to 80 of about 4,523 (159)

Skin barrier‐related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta‐analysis

Pediatric Allergy and Immunology, Volume 37, Issue 4, April 2026.
Abstract Atopic dermatitis (AD), asthma, food allergy, and respiratory allergy are common childhood conditions with significant disease burden. Current understanding implicates the skin‐barrier and the dual‐allergen hypotheses in the pathophysiology of these allergic conditions.
I. Husain, K. Patel, C. Holden, L. Jervis, K. Barnard, E. Youssef, J. Felton, S. Bremner, S. J. Brown, S. Mukhopadhyay   +9 more
wiley   +1 more source

Transcriptome-wide association study uncovers the role of essential genes in anthracycline-induced cardiotoxicity

npj Genomic Medicine, 2021
Anthracyclines are highly effective chemotherapeutic agents; however, their clinical utility is limited by severe anthracycline-induced cardiotoxicity (ACT).
Erika N. Scott, Galen E. B. Wright, Britt I. Drögemöller, Jafar S. Hasbullah, Erandika P. Gunaretnam, Fudan Miao, Amit P. Bhavsar, Fei Shen, Bryan P. Schneider, Bruce C. Carleton, Colin J. D. Ross   +10 more
doaj   +1 more source

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration [PDF]

, 2020
Genome-wide association studies (GWAS) for late stage age-related macular degeneration (AMD) have identified 52 independent genetic variants with genome-wide significance at 34 genomic loci.
Bailey, Jessica N.Cooke, Blangero, John, Bragg-Gresham, Jennifer L., Fritsche, Lars G., Grassmann, Felix, Igl, Wilmar, Johnson, Matthew P., Kiel, Christina, Lauwen, Susette, Sengupta, Sebanti, Strunz, Tobias   +10 more
core   +2 more sources

Bayesian genome-wide TWAS with reference transcriptomic data of brain and blood tissues identified 141 risk genes for Alzheimer’s disease dementia

Alzheimer’s Research & Therapy
Background Transcriptome-wide association study (TWAS) is an influential tool for identifying genes associated with complex diseases whose genetic effects are likely mediated through transcriptome.
Shuyi Guo, Jingjing Yang
doaj   +1 more source

Transcriptome-wide association study identifies new susceptibility genes for degenerative cervical spondylosis

Bone & Joint Research, 2023
AimsDegenerative cervical spondylosis (DCS) is a common musculoskeletal disease that encompasses a wide range of progressive degenerative changes and affects all components of the cervical spine.
Jiawen Xu, Haibo Si, Yi Zeng, Yuangang Wu, Shaoyun Zhang, Yuan Liu, Mingyang Li, Bin Shen   +7 more
doaj   +1 more source

FarmGTEx TWAS-server: An Interactive Web Server for Customized TWAS Analysis [PDF]

Transcriptome-wide association study (TWAS) is a powerful approach for investigating the molecular mechanisms linking genetic loci to complex phenotypes.
Bai, Zhonghao, Chen, Zitao, Fang, Lingzhao, Gao, Yahui, Li, Bingjie, Lin, Qing, Liu, George, Liu, Shuli, Pan, Yuchun, Teng, Jinyan, Wang, Qishan, Wu, Jun, Zhang, Zhe, Zhang, Zhe, Zhang, Zhenyang   +14 more
core   +1 more source

PTWAS: Investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis [PDF]

, 2020
We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits.
Barbeira A., Kyung Im H., Luca F., Pique-Regi R., Quick C., Wen X., Yu K., Zhang Y.   +7 more
core   +1 more source

Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt

Annals of Neurology, Volume 99, Issue 3, Page 566-587, March 2026.
[Color figure can be viewed at www.annalsofneurology.org] As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65 years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia.
Laura Ibanez, Cyril Pottier, Aleksandra Beric, Daniel Western, Muhammad Ali, Carlos Cruchaga   +5 more
wiley   +1 more source

Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identifies Candidate Genes Associated With Idiopathic Pulmonary Fibrosis

Frontiers in Genetics, 2020
Idiopathic pulmonary fibrosis (IPF) is a type of scarring lung disease characterized by a chronic, progressive, and irreversible decline in lung function. The genetic basis of IPF remains elusive.
Weiming Gong, Ping Guo, Lu Liu, Qingbo Guan, Qingbo Guan, Qingbo Guan, Zhongshang Yuan   +6 more
doaj   +1 more source

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, Volume 33, Issue 3, Page 194-207, March 2026.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source